TY - JOUR
T1 - Switching of bacterial adhesion to a glycosylated surface by reversible reorientation of the carbohydrate ligand
AU - Weber, Theresa
AU - Chrasekaran, Vijayan
AU - Stamer, Insa
AU - Thygesen, Mikkel Boas
AU - Terfort, Andreas
AU - Lindhorst, Thisbe K.
PY - 2014
Y1 - 2014
N2 - The surface recognition in many biological systems is guided by the interaction of carbohydrate-specific proteins (lectins) with carbohydrate epitopes (ligands) located within the unordered glycoconjugate layer (glycocalyx) of cells. Thus, for recognition, the respective ligand has to reorient for a successful matching event. Herein, we present for the first time a model system, in which only the orientation of the ligand is altered in a controlled manner without changing the recognition quality of the ligand itself. The key for this orientational control is the embedding into an interfacial system and the use of a photoswitchable mechanical joint, such as azobenzene.
AB - The surface recognition in many biological systems is guided by the interaction of carbohydrate-specific proteins (lectins) with carbohydrate epitopes (ligands) located within the unordered glycoconjugate layer (glycocalyx) of cells. Thus, for recognition, the respective ligand has to reorient for a successful matching event. Herein, we present for the first time a model system, in which only the orientation of the ligand is altered in a controlled manner without changing the recognition quality of the ligand itself. The key for this orientational control is the embedding into an interfacial system and the use of a photoswitchable mechanical joint, such as azobenzene.
KW - Azobenzene
KW - Carbohydrate
KW - Glycocalyx
KW - Lectin
KW - Light-induced switching
KW - Recognition
U2 - 10.1002/anie.201409808
DO - 10.1002/anie.201409808
M3 - Journal article
C2 - 25429860
AN - SCOPUS:84919686167
SN - 1433-7851
VL - 53
SP - 14583
EP - 14586
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
IS - 52
ER -