Swelling-activated ion channels: functional regulation in cell-swelling, proliferation and apoptosis.

TY - JOUR

T1 - Swelling-activated ion channels: functional regulation in cell-swelling, proliferation and apoptosis.

AU - Stutzin, A

AU - Hoffmann, E K

N1 - Keywords: Animals; Apoptosis; Cell Membrane; Cell Physiology; Cell Proliferation; Cell Size; Humans; Ion Channel Gating; Ion Channels; Osmolar Concentration; Signal Transduction

PY - 2006

Y1 - 2006

N2 - Cell volume regulation is one of the most fundamental homeostatic mechanisms and essential for normal cellular function. At the same time, however, many physiological mechanisms are associated with regulatory changes in cell size meaning that the set point for cell volume regulation is under physiological control. Thus, cell volume is under a tight and dynamic control and abnormal cell volume regulation will ultimately lead to severe cellular dysfunction, including alterations in cell proliferation and cell death. This review describes the different swelling-activated ion channels that participate as key players in the maintenance of normal steady-state cell volume, with particular emphasis on the intracellular signalling pathways responsible for their regulation during hypotonic stress, cell proliferation and apoptosis.

AB - Cell volume regulation is one of the most fundamental homeostatic mechanisms and essential for normal cellular function. At the same time, however, many physiological mechanisms are associated with regulatory changes in cell size meaning that the set point for cell volume regulation is under physiological control. Thus, cell volume is under a tight and dynamic control and abnormal cell volume regulation will ultimately lead to severe cellular dysfunction, including alterations in cell proliferation and cell death. This review describes the different swelling-activated ion channels that participate as key players in the maintenance of normal steady-state cell volume, with particular emphasis on the intracellular signalling pathways responsible for their regulation during hypotonic stress, cell proliferation and apoptosis.

U2 - 10.1111/j.1748-1716.2006.01537.x

DO - 10.1111/j.1748-1716.2006.01537.x

M3 - Journal article

C2 - 16734740

SN - 1748-1708

VL - 187

SP - 27

EP - 42

JO - Acta Physiologica

JF - Acta Physiologica

IS - 1-2

ER -