Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder: A Nationwide Observational Cohort Study

Birgitte Klee Burton; Signe Vangkilde; Anders Petersen; Lene Theil Skovgaard; Jens Richardt Jepsen; Nicoline Hemager; Camilla Jerlang Christiani; Katrine Soeborg Spang; Ditte Ellersgaard; Aja Greve; Ditte Gantriis; Heike Eichele; Ole Mors; Merete Nordentoft; Anne Amalie Elgaard Thorup; Kerstin Jessica Plessen

doi:10.1016/j.bpsc.2018.04.012

Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder: A Nationwide Observational Cohort Study

Birgitte Klee Burton^*, Signe Vangkilde, Anders Petersen, Lene Theil Skovgaard, Jens Richardt Jepsen, Nicoline Hemager, Camilla Jerlang Christiani, Katrine Soeborg Spang, Ditte Ellersgaard, Aja Greve, Ditte Gantriis, Heike Eichele, Ole Mors, Merete Nordentoft, Anne Amalie Elgaard Thorup, Kerstin Jessica Plessen

^*Corresponding author for this work

11 Citations (Scopus)

Abstract

Background: Given the partially shared genetic liability between schizophrenia and bipolar disorder, we aimed to assess whether 7-year-old children with a familial high risk of schizophrenia or bipolar disorder display specific deficits of sustained attention and interference control compared with each other and with control children. Methods: An observational cohort was identified through Danish registries and consisted of 522 children 7 years of age with no, one, or two parents with a diagnosis of schizophrenia or bipolar disorder. Control subjects were matched based on age, sex, and municipality. Sustained attention and interference control were assessed using Conners’ Continuous Performance Test II and a modified Eriksen flanker task. Assessors were blinded to group membership of participants. The effect of higher genetic loading was not considered in the statistical models owing to low numbers. Results: At 7 years of age, children with a familial high risk of schizophrenia displayed deficits of sustained attention and subtle deficits in interference control compared with control children and children with a familial high risk of bipolar disorder. Children with a familial high risk of bipolar disorder displayed similar abilities of sustained attention and interference control as control children except in terms of a lower accuracy. Conclusions: Our findings suggest distinct neurodevelopmental characteristics in middle childhood of sustained attention and interference control for children of parents with schizophrenia or bipolar disorder.

Original language	English
Journal	Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Volume	3
Issue number	8
Pages (from-to)	704-712
ISSN	2451-9022
DOIs	https://doi.org/10.1016/j.bpsc.2018.04.012
Publication status	Published - Aug 2018

Keywords

Attention
Bipolar disorder
Endophenotypes
First-degree relatives
Interference control
Schizophrenia

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Burton, B. K., Vangkilde, S., Petersen, A., Skovgaard, L. T., Jepsen, J. R., Hemager, N., Christiani, C. J., Spang, K. S., Ellersgaard, D., Greve, A., Gantriis, D., Eichele, H., Mors, O., Nordentoft, M., Thorup, A. A. E., & Plessen, K. J. (2018). Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder: A Nationwide Observational Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3(8), 704-712. https://doi.org/10.1016/j.bpsc.2018.04.012

Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder : A Nationwide Observational Cohort Study. / Burton, Birgitte Klee; Vangkilde, Signe ; Petersen, Anders et al.

In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 3, No. 8, 08.2018, p. 704-712.

Research output: Contribution to journal › Journal article › Research › peer-review

Burton, BK, Vangkilde, S , Petersen, A , Skovgaard, LT, Jepsen, JR, Hemager, N, Christiani, CJ, Spang, KS, Ellersgaard, D, Greve, A, Gantriis, D, Eichele, H, Mors, O, Nordentoft, M , Thorup, AAE & Plessen, KJ 2018, 'Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder: A Nationwide Observational Cohort Study', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 3, no. 8, pp. 704-712. https://doi.org/10.1016/j.bpsc.2018.04.012

Burton BK, Vangkilde S , Petersen A , Skovgaard LT, Jepsen JR, Hemager N et al. Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder: A Nationwide Observational Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2018 Aug;3(8):704-712. doi: 10.1016/j.bpsc.2018.04.012

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title = "Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder: A Nationwide Observational Cohort Study",

abstract = "Background: Given the partially shared genetic liability between schizophrenia and bipolar disorder, we aimed to assess whether 7-year-old children with a familial high risk of schizophrenia or bipolar disorder display specific deficits of sustained attention and interference control compared with each other and with control children. Methods: An observational cohort was identified through Danish registries and consisted of 522 children 7 years of age with no, one, or two parents with a diagnosis of schizophrenia or bipolar disorder. Control subjects were matched based on age, sex, and municipality. Sustained attention and interference control were assessed using Conners{\textquoteright} Continuous Performance Test II and a modified Eriksen flanker task. Assessors were blinded to group membership of participants. The effect of higher genetic loading was not considered in the statistical models owing to low numbers. Results: At 7 years of age, children with a familial high risk of schizophrenia displayed deficits of sustained attention and subtle deficits in interference control compared with control children and children with a familial high risk of bipolar disorder. Children with a familial high risk of bipolar disorder displayed similar abilities of sustained attention and interference control as control children except in terms of a lower accuracy. Conclusions: Our findings suggest distinct neurodevelopmental characteristics in middle childhood of sustained attention and interference control for children of parents with schizophrenia or bipolar disorder.",

keywords = "Attention, Bipolar disorder, Endophenotypes, First-degree relatives, Interference control, Schizophrenia",

author = "Burton, {Birgitte Klee} and Signe Vangkilde and Anders Petersen and Skovgaard, {Lene Theil} and Jepsen, {Jens Richardt} and Nicoline Hemager and Christiani, {Camilla Jerlang} and Spang, {Katrine Soeborg} and Ditte Ellersgaard and Aja Greve and Ditte Gantriis and Heike Eichele and Ole Mors and Merete Nordentoft and Thorup, {Anne Amalie Elgaard} and Plessen, {Kerstin Jessica}",

year = "2018",

month = aug,

doi = "10.1016/j.bpsc.2018.04.012",

language = "English",

volume = "3",

pages = "704--712",

journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",

issn = "2451-9022",

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T1 - Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder

T2 - A Nationwide Observational Cohort Study

AU - Burton, Birgitte Klee

AU - Vangkilde, Signe

AU - Petersen, Anders

AU - Skovgaard, Lene Theil

AU - Jepsen, Jens Richardt

AU - Hemager, Nicoline

AU - Christiani, Camilla Jerlang

AU - Spang, Katrine Soeborg

AU - Ellersgaard, Ditte

AU - Greve, Aja

AU - Gantriis, Ditte

AU - Eichele, Heike

AU - Mors, Ole

AU - Nordentoft, Merete

AU - Thorup, Anne Amalie Elgaard

AU - Plessen, Kerstin Jessica

PY - 2018/8

Y1 - 2018/8

N2 - Background: Given the partially shared genetic liability between schizophrenia and bipolar disorder, we aimed to assess whether 7-year-old children with a familial high risk of schizophrenia or bipolar disorder display specific deficits of sustained attention and interference control compared with each other and with control children. Methods: An observational cohort was identified through Danish registries and consisted of 522 children 7 years of age with no, one, or two parents with a diagnosis of schizophrenia or bipolar disorder. Control subjects were matched based on age, sex, and municipality. Sustained attention and interference control were assessed using Conners’ Continuous Performance Test II and a modified Eriksen flanker task. Assessors were blinded to group membership of participants. The effect of higher genetic loading was not considered in the statistical models owing to low numbers. Results: At 7 years of age, children with a familial high risk of schizophrenia displayed deficits of sustained attention and subtle deficits in interference control compared with control children and children with a familial high risk of bipolar disorder. Children with a familial high risk of bipolar disorder displayed similar abilities of sustained attention and interference control as control children except in terms of a lower accuracy. Conclusions: Our findings suggest distinct neurodevelopmental characteristics in middle childhood of sustained attention and interference control for children of parents with schizophrenia or bipolar disorder.

AB - Background: Given the partially shared genetic liability between schizophrenia and bipolar disorder, we aimed to assess whether 7-year-old children with a familial high risk of schizophrenia or bipolar disorder display specific deficits of sustained attention and interference control compared with each other and with control children. Methods: An observational cohort was identified through Danish registries and consisted of 522 children 7 years of age with no, one, or two parents with a diagnosis of schizophrenia or bipolar disorder. Control subjects were matched based on age, sex, and municipality. Sustained attention and interference control were assessed using Conners’ Continuous Performance Test II and a modified Eriksen flanker task. Assessors were blinded to group membership of participants. The effect of higher genetic loading was not considered in the statistical models owing to low numbers. Results: At 7 years of age, children with a familial high risk of schizophrenia displayed deficits of sustained attention and subtle deficits in interference control compared with control children and children with a familial high risk of bipolar disorder. Children with a familial high risk of bipolar disorder displayed similar abilities of sustained attention and interference control as control children except in terms of a lower accuracy. Conclusions: Our findings suggest distinct neurodevelopmental characteristics in middle childhood of sustained attention and interference control for children of parents with schizophrenia or bipolar disorder.

KW - Attention

KW - Bipolar disorder

KW - Endophenotypes

KW - First-degree relatives

KW - Interference control

KW - Schizophrenia

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DO - 10.1016/j.bpsc.2018.04.012

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C2 - 29909148

AN - SCOPUS:85048932323

SN - 2451-9022

VL - 3

SP - 704

EP - 712

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

IS - 8

ER -

Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder: A Nationwide Observational Cohort Study

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