Survival in patients without acute ST elevation after cardiac arrest and association with early coronary angiography: a post hoc analysis from the TTM trial

TY - JOUR

T1 - Survival in patients without acute ST elevation after cardiac arrest and association with early coronary angiography

T2 - a post hoc analysis from the TTM trial

AU - Dankiewicz, J

AU - Nielsen, N

AU - Annborn, M

AU - Cronberg, T

AU - Erlinge, D

AU - Gasche, Y

AU - Hassager, C

AU - Kjaergaard, J

AU - Pellis, T

AU - Friberg, H

PY - 2015/5/1

Y1 - 2015/5/1

N2 - PURPOSE: To investigate whether early coronary angiography (CAG) after out-of-hospital cardiac arrest of a presumed cardiac cause is associated with improved outcomes in patients without acute ST elevation.METHODS: The target temperature management after out-of-hospital cardiac arrest (TTM) trial showed no difference in all-cause mortality or neurological outcome between an intervention of 33 and 36 °C. In this post hoc analysis, 544 patients where the admission electrocardiogram did not show acute ST elevation were included. Early CAG was defined as being performed on admission or within the first 6 h after arrest. Primary outcome was mortality at the end of trial. A Cox proportional hazard model was created to estimate hazard of death, adjusting for covariates. In addition, a propensity score matched analysis was performed.RESULTS: A total of 252 patients (46 %) received early CAG, whereas 292 (54 %) did not. At the end of the trial, 122 of 252 patients who received an early CAG (48 %) and 159 of 292 patients who did not (54 %) had died. The adjusted hazard ratio for death was 1.03 in the group that received an early CAG; 95 % CI 0.80-1.32, p = 0.82. In the propensity score analysis early CAG was not significantly associated with survival.CONCLUSIONS: In this post hoc observational study of a large randomized trial, early coronary angiography for patients without acute ST elevation after out-of-hospital cardiac arrest of a presumed cardiac cause was not associated with improved survival. A randomized trial is warranted to guide clinical practice.

AB - PURPOSE: To investigate whether early coronary angiography (CAG) after out-of-hospital cardiac arrest of a presumed cardiac cause is associated with improved outcomes in patients without acute ST elevation.METHODS: The target temperature management after out-of-hospital cardiac arrest (TTM) trial showed no difference in all-cause mortality or neurological outcome between an intervention of 33 and 36 °C. In this post hoc analysis, 544 patients where the admission electrocardiogram did not show acute ST elevation were included. Early CAG was defined as being performed on admission or within the first 6 h after arrest. Primary outcome was mortality at the end of trial. A Cox proportional hazard model was created to estimate hazard of death, adjusting for covariates. In addition, a propensity score matched analysis was performed.RESULTS: A total of 252 patients (46 %) received early CAG, whereas 292 (54 %) did not. At the end of the trial, 122 of 252 patients who received an early CAG (48 %) and 159 of 292 patients who did not (54 %) had died. The adjusted hazard ratio for death was 1.03 in the group that received an early CAG; 95 % CI 0.80-1.32, p = 0.82. In the propensity score analysis early CAG was not significantly associated with survival.CONCLUSIONS: In this post hoc observational study of a large randomized trial, early coronary angiography for patients without acute ST elevation after out-of-hospital cardiac arrest of a presumed cardiac cause was not associated with improved survival. A randomized trial is warranted to guide clinical practice.

KW - Aged

KW - Australia

KW - Body Temperature

KW - Coronary Angiography

KW - Coronary Thrombosis

KW - Early Diagnosis

KW - Europe

KW - Female

KW - Humans

KW - Hypotension, Controlled

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Out-of-Hospital Cardiac Arrest

KW - Survival

U2 - 10.1007/s00134-015-3735-z

DO - 10.1007/s00134-015-3735-z

M3 - Journal article

C2 - 25800582

SN - 0935-1701

VL - 41

SP - 856

EP - 864

JO - European Journal of Intensive Care Medicine

JF - European Journal of Intensive Care Medicine

IS - 5

ER -