Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Friederike Erdmann; Jeanette Falck Winther; Susanne Oksbjerg Dalton; Hajo Zeeb; Anja Krøyer; Andrea Bautz; Kjeld Schmiegelow; Joachim Schüz

doi:10.1002/ijc.31082

Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Friederike Erdmann, Jeanette Falck Winther, Susanne Oksbjerg Dalton, Hajo Zeeb, Anja Krøyer, Andrea Bautz, Kjeld Schmiegelow, Joachim Schüz

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

Little is known about social inequalities in childhood cancer survival. We investigated the impact of family circumstances on survival from paediatric central nervous system (CNS) tumours in a nationwide, register-based cohort of Danish children. All children born between 1973 and 2006 and diagnosed with a CNS tumour before the age of 20 years (N = 1,261) were followed until 10 years from diagnosis. Using Cox proportional hazards models, the impact of various family characteristics on overall survival was estimated. Hazard ratios (HRs) for all CNS tumours combined did not show strong associations between survival and any family characteristic. Analyses by CNS tumour subtypes showed reduced survival for children with glioma when living outside of Copenhagen (HR 1.55; CI 1.03; 2.35). For embryonal CNS tumours, the number of full siblings was associated with worse survival (HR for having 3+ siblings 3.60; CI 1.52; 8.53) and a trend of better survival was observed for children with parents of younger age at child's diagnosis and poorer survival of children with parents of older age. Despite free and uniform access to health care services, some family circumstances appear to affect survival from specific CNS tumour types in Danish children. Further research is warranted to gain a more comprehensive understanding of the impact of family factors on childhood cancer survival in other populations and to elaborate underlying mechanisms and pathways of those survival inequalities observed.

Original language	English
Journal	International Journal of Cancer
Volume	142
Issue number	4
Pages (from-to)	671-680
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.31082
Publication status	Published - 15 Feb 2018

Keywords

Adolescent
Adult
Central Nervous System Neoplasms/epidemiology
Child
Child, Preschool
Cohort Studies
Denmark/epidemiology
Family Characteristics
Female
Humans
Infant
Infant, Newborn
Male
Prognosis
Registries/statistics & numerical data
Survival Rate
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?",

abstract = "Little is known about social inequalities in childhood cancer survival. We investigated the impact of family circumstances on survival from paediatric central nervous system (CNS) tumours in a nationwide, register-based cohort of Danish children. All children born between 1973 and 2006 and diagnosed with a CNS tumour before the age of 20 years (N = 1,261) were followed until 10 years from diagnosis. Using Cox proportional hazards models, the impact of various family characteristics on overall survival was estimated. Hazard ratios (HRs) for all CNS tumours combined did not show strong associations between survival and any family characteristic. Analyses by CNS tumour subtypes showed reduced survival for children with glioma when living outside of Copenhagen (HR 1.55; CI 1.03; 2.35). For embryonal CNS tumours, the number of full siblings was associated with worse survival (HR for having 3+ siblings 3.60; CI 1.52; 8.53) and a trend of better survival was observed for children with parents of younger age at child's diagnosis and poorer survival of children with parents of older age. Despite free and uniform access to health care services, some family circumstances appear to affect survival from specific CNS tumour types in Danish children. Further research is warranted to gain a more comprehensive understanding of the impact of family factors on childhood cancer survival in other populations and to elaborate underlying mechanisms and pathways of those survival inequalities observed.",

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author = "Friederike Erdmann and Winther, {Jeanette Falck} and Dalton, {Susanne Oksbjerg} and Hajo Zeeb and Anja Kr{\o}yer and Andrea Bautz and Kjeld Schmiegelow and Joachim Sch{\"u}z",

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doi = "10.1002/ijc.31082",

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T1 - Survival from tumours of the central nervous system in Danish children

T2 - Is survival related to family circumstances?

AU - Erdmann, Friederike

AU - Winther, Jeanette Falck

AU - Dalton, Susanne Oksbjerg

AU - Zeeb, Hajo

AU - Krøyer, Anja

AU - Bautz, Andrea

AU - Schmiegelow, Kjeld

AU - Schüz, Joachim

PY - 2018/2/15

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N2 - Little is known about social inequalities in childhood cancer survival. We investigated the impact of family circumstances on survival from paediatric central nervous system (CNS) tumours in a nationwide, register-based cohort of Danish children. All children born between 1973 and 2006 and diagnosed with a CNS tumour before the age of 20 years (N = 1,261) were followed until 10 years from diagnosis. Using Cox proportional hazards models, the impact of various family characteristics on overall survival was estimated. Hazard ratios (HRs) for all CNS tumours combined did not show strong associations between survival and any family characteristic. Analyses by CNS tumour subtypes showed reduced survival for children with glioma when living outside of Copenhagen (HR 1.55; CI 1.03; 2.35). For embryonal CNS tumours, the number of full siblings was associated with worse survival (HR for having 3+ siblings 3.60; CI 1.52; 8.53) and a trend of better survival was observed for children with parents of younger age at child's diagnosis and poorer survival of children with parents of older age. Despite free and uniform access to health care services, some family circumstances appear to affect survival from specific CNS tumour types in Danish children. Further research is warranted to gain a more comprehensive understanding of the impact of family factors on childhood cancer survival in other populations and to elaborate underlying mechanisms and pathways of those survival inequalities observed.

AB - Little is known about social inequalities in childhood cancer survival. We investigated the impact of family circumstances on survival from paediatric central nervous system (CNS) tumours in a nationwide, register-based cohort of Danish children. All children born between 1973 and 2006 and diagnosed with a CNS tumour before the age of 20 years (N = 1,261) were followed until 10 years from diagnosis. Using Cox proportional hazards models, the impact of various family characteristics on overall survival was estimated. Hazard ratios (HRs) for all CNS tumours combined did not show strong associations between survival and any family characteristic. Analyses by CNS tumour subtypes showed reduced survival for children with glioma when living outside of Copenhagen (HR 1.55; CI 1.03; 2.35). For embryonal CNS tumours, the number of full siblings was associated with worse survival (HR for having 3+ siblings 3.60; CI 1.52; 8.53) and a trend of better survival was observed for children with parents of younger age at child's diagnosis and poorer survival of children with parents of older age. Despite free and uniform access to health care services, some family circumstances appear to affect survival from specific CNS tumour types in Danish children. Further research is warranted to gain a more comprehensive understanding of the impact of family factors on childhood cancer survival in other populations and to elaborate underlying mechanisms and pathways of those survival inequalities observed.

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KW - Adult

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KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Family Characteristics

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Prognosis

KW - Registries/statistics & numerical data

KW - Survival Rate

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U2 - 10.1002/ijc.31082

DO - 10.1002/ijc.31082

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SN - 0020-7136

VL - 142

SP - 671

EP - 680

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 4

ER -

Survival from tumours of the central nervous system in Danish children: Is survival related to family circumstances?

Abstract

Keywords

UN SDGs

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