Survival after liver transplantation of patients with primary biliary cirrhosis in the nordic countries comparison with expected survival in another series of transplantations and in an international trial of medical treatment

S. Keiding; B.-G. Ericzon; S. Eriksson; A. Flatmark; K. Höckerstedt; H. Isoniemi; I. Karlberg; N. Keiding; R. Olsson; K. Samela; E. Schrumpf; C. Söderman

doi:10.3109/00365529008999204

Survival after liver transplantation of patients with primary biliary cirrhosis in the nordic countries comparison with expected survival in another series of transplantations and in an international trial of medical treatment

S. Keiding^*, B.-G. Ericzon, S. Eriksson, A. Flatmark, K. Höckerstedt, H. Isoniemi, I. Karlberg, N. Keiding, R. Olsson, K. Samela, E. Schrumpf, C. Söderman

^*Corresponding author for this work

30 Citations (Scopus)

Abstract

Until December 1988, 38 patients with primary biliary cirrhosis (PBC) had been transplanted in the Nordic countries. The observed survival probability in accordance with Kaplan-Meier analysis was around 75% 2-3 months after surgery, with few deaths during the next 3 years. The observed survival curve was compared with the expected survival calculated from the experience of a recent English PBC transplant series; the patterns are very similar. Secondly, the observed survival was compared with the expected survival curve, calculated from the survival experience of an international trial of medical treatment-that is, the expected survival had the patients not been transplanted; after the first 2-3 months the observed survival stayed better than the expected survival. Finally, the merits of transplantation for each particular patient was evaluated by means of the ratio of probability of survival when transplanted to probability of survival when medically treated 3, 6. and 8 months after surgery. The ratio increased with time, indicating a relative increase in the benefit of transplantation with time after surgery.

Original language	English
Book series	Scandinavian Journal of Gastroenterology
Volume	25
Issue number	1
Pages (from-to)	11-18
Number of pages	8
ISSN	0036-5521
DOIs	https://doi.org/10.3109/00365529008999204
Publication status	Published - 1 Jan 1990

Keywords

Kaplan-Meier analysis
Liver transplantation
Primary biliary cirrhosis
Survival

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Keiding, S., Ericzon, B-G., Eriksson, S., Flatmark, A., Höckerstedt, K., Isoniemi, H., Karlberg, I., Keiding, N., Olsson, R., Samela, K., Schrumpf, E., & Söderman, C. (1990). Survival after liver transplantation of patients with primary biliary cirrhosis in the nordic countries comparison with expected survival in another series of transplantations and in an international trial of medical treatment. Scandinavian Journal of Gastroenterology, 25(1), 11-18. https://doi.org/10.3109/00365529008999204

Survival after liver transplantation of patients with primary biliary cirrhosis in the nordic countries comparison with expected survival in another series of transplantations and in an international trial of medical treatment. / Keiding, S.; Ericzon, B.-G.; Eriksson, S. et al.

In: Scandinavian Journal of Gastroenterology, Vol. 25, No. 1, 01.01.1990, p. 11-18.

Research output: Contribution to journal › Journal article › Research › peer-review

Keiding, S, Ericzon, B-G, Eriksson, S, Flatmark, A, Höckerstedt, K, Isoniemi, H, Karlberg, I, Keiding, N, Olsson, R, Samela, K, Schrumpf, E & Söderman, C 1990, 'Survival after liver transplantation of patients with primary biliary cirrhosis in the nordic countries comparison with expected survival in another series of transplantations and in an international trial of medical treatment', Scandinavian Journal of Gastroenterology, vol. 25, no. 1, pp. 11-18. https://doi.org/10.3109/00365529008999204

Keiding S, Ericzon B-G, Eriksson S, Flatmark A, Höckerstedt K, Isoniemi H et al. Survival after liver transplantation of patients with primary biliary cirrhosis in the nordic countries comparison with expected survival in another series of transplantations and in an international trial of medical treatment. Scandinavian Journal of Gastroenterology. 1990 Jan 1;25(1):11-18. doi: 10.3109/00365529008999204

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abstract = "Until December 1988, 38 patients with primary biliary cirrhosis (PBC) had been transplanted in the Nordic countries. The observed survival probability in accordance with Kaplan-Meier analysis was around 75% 2-3 months after surgery, with few deaths during the next 3 years. The observed survival curve was compared with the expected survival calculated from the experience of a recent English PBC transplant series; the patterns are very similar. Secondly, the observed survival was compared with the expected survival curve, calculated from the survival experience of an international trial of medical treatment-that is, the expected survival had the patients not been transplanted; after the first 2-3 months the observed survival stayed better than the expected survival. Finally, the merits of transplantation for each particular patient was evaluated by means of the ratio of probability of survival when transplanted to probability of survival when medically treated 3, 6. and 8 months after surgery. The ratio increased with time, indicating a relative increase in the benefit of transplantation with time after surgery.",

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AU - Höckerstedt, K.

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AU - Keiding, N.

AU - Olsson, R.

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AU - Schrumpf, E.

AU - Söderman, C.

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AB - Until December 1988, 38 patients with primary biliary cirrhosis (PBC) had been transplanted in the Nordic countries. The observed survival probability in accordance with Kaplan-Meier analysis was around 75% 2-3 months after surgery, with few deaths during the next 3 years. The observed survival curve was compared with the expected survival calculated from the experience of a recent English PBC transplant series; the patterns are very similar. Secondly, the observed survival was compared with the expected survival curve, calculated from the survival experience of an international trial of medical treatment-that is, the expected survival had the patients not been transplanted; after the first 2-3 months the observed survival stayed better than the expected survival. Finally, the merits of transplantation for each particular patient was evaluated by means of the ratio of probability of survival when transplanted to probability of survival when medically treated 3, 6. and 8 months after surgery. The ratio increased with time, indicating a relative increase in the benefit of transplantation with time after surgery.

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Survival after liver transplantation of patients with primary biliary cirrhosis in the nordic countries comparison with expected survival in another series of transplantations and in an international trial of medical treatment

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Keywords

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