Surveying selenium speciation from soil to cell-forms and transformations

Bente Gammelgaard; Matthew I. Jackson; Charlotte Gabel-Jensen

doi:10.1007/s00216-010-4212-8

Surveying selenium speciation from soil to cell-forms and transformations

Bente Gammelgaard, Matthew I. Jackson, Charlotte Gabel-Jensen

53 Citations (Scopus)

Abstract

The aim of this review is to present and evaluate the present knowledge of which selenium species are available to the general population in the form of food and common supplements and how these species are metabolized in mammals. The overview of the selenium sources takes a horizontal approach, which encompasses identification of new metabolites in yeast and food of plant and animal origin, whereas the survey of the mammalian metabolism takes a horizontal as well as a vertical approach. The vertical approach encompasses studies on dynamic conversions of selenium compounds within cells, tissues or whole organisms. New and improved sample preparation, separation and detection methods are evaluated from an analytical chemical perspective to cover the progress in horizontal speciation, whereas the analytical methods for the vertical speciation and the interpretations of the results are evaluated from a biological angle as well.

Original language	English
Journal	Analytical and Bioanalytical Chemistry
Volume	399
Pages (from-to)	1743-1763
ISSN	1618-2642
DOIs	https://doi.org/10.1007/s00216-010-4212-8
Publication status	Published - Feb 2011

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Former Faculty of Pharmaceutical Sciences

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10.1007/s00216-010-4212-8

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N2 - The aim of this review is to present and evaluate the present knowledge of which selenium species are available to the general population in the form of food and common supplements and how these species are metabolized in mammals. The overview of the selenium sources takes a horizontal approach, which encompasses identification of new metabolites in yeast and food of plant and animal origin, whereas the survey of the mammalian metabolism takes a horizontal as well as a vertical approach. The vertical approach encompasses studies on dynamic conversions of selenium compounds within cells, tissues or whole organisms. New and improved sample preparation, separation and detection methods are evaluated from an analytical chemical perspective to cover the progress in horizontal speciation, whereas the analytical methods for the vertical speciation and the interpretations of the results are evaluated from a biological angle as well.

AB - The aim of this review is to present and evaluate the present knowledge of which selenium species are available to the general population in the form of food and common supplements and how these species are metabolized in mammals. The overview of the selenium sources takes a horizontal approach, which encompasses identification of new metabolites in yeast and food of plant and animal origin, whereas the survey of the mammalian metabolism takes a horizontal as well as a vertical approach. The vertical approach encompasses studies on dynamic conversions of selenium compounds within cells, tissues or whole organisms. New and improved sample preparation, separation and detection methods are evaluated from an analytical chemical perspective to cover the progress in horizontal speciation, whereas the analytical methods for the vertical speciation and the interpretations of the results are evaluated from a biological angle as well.

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JF - Analytical and Bioanalytical Chemistry

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Surveying selenium speciation from soil to cell-forms and transformations

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