Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study

Sven Petter Haugvik; Eva Tiensuu Janson; Pia Österlund; Seppo W. Langer; Ragnhild Sørum Falk; Knut Jørgen Labori; Lene Weber Vestermark; Henning Grønbaek; Ivar Prydz Gladhaug; Halfdan Sorbye

doi:10.1245/s10434-015-5013-2

Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study

Sven Petter Haugvik^*, Eva Tiensuu Janson, Pia Österlund, Seppo W. Langer, Ragnhild Sørum Falk, Knut Jørgen Labori, Lene Weber Vestermark, Henning Grønbaek, Ivar Prydz Gladhaug, Halfdan Sorbye

^*Corresponding author for this work

Department of Drug Design and Pharmacology

38 Citations (Scopus)

Abstract

Background: This study aimed to evaluate the role of surgery for patients with high-grade pancreatic neuroendocrine carcinoma (hgPNEC) in a large Nordic multicenter cohort study. Prior studies evaluating the role of surgery for patients with hgPNEC are limited, and the benefit of the surgery is uncertain. Methods: Data from patients with a diagnosis of hgPNEC determined between 1998 and 2012 were retrospectively registered at 10 Nordic university hospitals. Kaplan–Meier curves were used to compare the overall survival of different treatment groups, and Cox-regression analysis was used to evaluate factors potentially influencing survival. Results: The study registered 119 patients. The median survival period from the time of metastasis was 23 months for patients undergoing initial resection of localized nonmetastatic disease and chemotherapy at the time of recurrence (n = 14), 29 months for patients undergoing resection of the primary tumor and resection/radiofrequency ablation of synchronous metastatic liver disease (n = 12), and 13 months for patients with synchronous metastatic disease given systemic chemotherapy alone (n = 78). The 3-year survival rate after surgery of the primary tumor and metastatic disease was 69 %. Resection of the primary tumor was an independent factor for improved survival after occurrence of metastatic disease. Conclusions: Patients with resected localized nonmetastatic hgPNEC and later metastatic disease seemed to benefit from initial resection of the primary tumor. Patients selected for resection of the primary tumor and synchronous liver metastases had a high 3-year survival rate. Selected patients with both localized hgPNEC and metastatic hgPNEC should be considered for radical surgical treatment.

Original language	English
Journal	Annals of Surgical Oncology
Volume	23
Issue number	5
Pages (from-to)	1721-1728
Number of pages	8
ISSN	1068-9265
DOIs	https://doi.org/10.1245/s10434-015-5013-2
Publication status	Published - 1 May 2016

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Haugvik, S. P., Janson, E. T., Österlund, P., Langer, S. W., Falk, R. S., Labori, K. J., Vestermark, L. W., Grønbaek, H., Gladhaug, I. P., & Sorbye, H. (2016). Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study. Annals of Surgical Oncology, 23(5), 1721-1728. https://doi.org/10.1245/s10434-015-5013-2

Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study. / Haugvik, Sven Petter; Janson, Eva Tiensuu; Österlund, Pia et al.
In: Annals of Surgical Oncology, Vol. 23, No. 5, 01.05.2016, p. 1721-1728.

Research output: Contribution to journal › Journal article › Research › peer-review

Haugvik, SP, Janson, ET, Österlund, P, Langer, SW, Falk, RS, Labori, KJ, Vestermark, LW, Grønbaek, H, Gladhaug, IP & Sorbye, H 2016, 'Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study', Annals of Surgical Oncology, vol. 23, no. 5, pp. 1721-1728. https://doi.org/10.1245/s10434-015-5013-2

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title = "Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study",

abstract = "Background: This study aimed to evaluate the role of surgery for patients with high-grade pancreatic neuroendocrine carcinoma (hgPNEC) in a large Nordic multicenter cohort study. Prior studies evaluating the role of surgery for patients with hgPNEC are limited, and the benefit of the surgery is uncertain. Methods: Data from patients with a diagnosis of hgPNEC determined between 1998 and 2012 were retrospectively registered at 10 Nordic university hospitals. Kaplan–Meier curves were used to compare the overall survival of different treatment groups, and Cox-regression analysis was used to evaluate factors potentially influencing survival. Results: The study registered 119 patients. The median survival period from the time of metastasis was 23 months for patients undergoing initial resection of localized nonmetastatic disease and chemotherapy at the time of recurrence (n = 14), 29 months for patients undergoing resection of the primary tumor and resection/radiofrequency ablation of synchronous metastatic liver disease (n = 12), and 13 months for patients with synchronous metastatic disease given systemic chemotherapy alone (n = 78). The 3-year survival rate after surgery of the primary tumor and metastatic disease was 69 %. Resection of the primary tumor was an independent factor for improved survival after occurrence of metastatic disease. Conclusions: Patients with resected localized nonmetastatic hgPNEC and later metastatic disease seemed to benefit from initial resection of the primary tumor. Patients selected for resection of the primary tumor and synchronous liver metastases had a high 3-year survival rate. Selected patients with both localized hgPNEC and metastatic hgPNEC should be considered for radical surgical treatment.",

author = "Haugvik, {Sven Petter} and Janson, {Eva Tiensuu} and Pia {\"O}sterlund and Langer, {Seppo W.} and Falk, {Ragnhild S{\o}rum} and Labori, {Knut J{\o}rgen} and Vestermark, {Lene Weber} and Henning Gr{\o}nbaek and Gladhaug, {Ivar Prydz} and Halfdan Sorbye",

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doi = "10.1245/s10434-015-5013-2",

language = "English",

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T1 - Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma

T2 - A Nordic Multicenter Comparative Study

AU - Haugvik, Sven Petter

AU - Janson, Eva Tiensuu

AU - Österlund, Pia

AU - Langer, Seppo W.

AU - Falk, Ragnhild Sørum

AU - Labori, Knut Jørgen

AU - Vestermark, Lene Weber

AU - Grønbaek, Henning

AU - Gladhaug, Ivar Prydz

AU - Sorbye, Halfdan

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: This study aimed to evaluate the role of surgery for patients with high-grade pancreatic neuroendocrine carcinoma (hgPNEC) in a large Nordic multicenter cohort study. Prior studies evaluating the role of surgery for patients with hgPNEC are limited, and the benefit of the surgery is uncertain. Methods: Data from patients with a diagnosis of hgPNEC determined between 1998 and 2012 were retrospectively registered at 10 Nordic university hospitals. Kaplan–Meier curves were used to compare the overall survival of different treatment groups, and Cox-regression analysis was used to evaluate factors potentially influencing survival. Results: The study registered 119 patients. The median survival period from the time of metastasis was 23 months for patients undergoing initial resection of localized nonmetastatic disease and chemotherapy at the time of recurrence (n = 14), 29 months for patients undergoing resection of the primary tumor and resection/radiofrequency ablation of synchronous metastatic liver disease (n = 12), and 13 months for patients with synchronous metastatic disease given systemic chemotherapy alone (n = 78). The 3-year survival rate after surgery of the primary tumor and metastatic disease was 69 %. Resection of the primary tumor was an independent factor for improved survival after occurrence of metastatic disease. Conclusions: Patients with resected localized nonmetastatic hgPNEC and later metastatic disease seemed to benefit from initial resection of the primary tumor. Patients selected for resection of the primary tumor and synchronous liver metastases had a high 3-year survival rate. Selected patients with both localized hgPNEC and metastatic hgPNEC should be considered for radical surgical treatment.

AB - Background: This study aimed to evaluate the role of surgery for patients with high-grade pancreatic neuroendocrine carcinoma (hgPNEC) in a large Nordic multicenter cohort study. Prior studies evaluating the role of surgery for patients with hgPNEC are limited, and the benefit of the surgery is uncertain. Methods: Data from patients with a diagnosis of hgPNEC determined between 1998 and 2012 were retrospectively registered at 10 Nordic university hospitals. Kaplan–Meier curves were used to compare the overall survival of different treatment groups, and Cox-regression analysis was used to evaluate factors potentially influencing survival. Results: The study registered 119 patients. The median survival period from the time of metastasis was 23 months for patients undergoing initial resection of localized nonmetastatic disease and chemotherapy at the time of recurrence (n = 14), 29 months for patients undergoing resection of the primary tumor and resection/radiofrequency ablation of synchronous metastatic liver disease (n = 12), and 13 months for patients with synchronous metastatic disease given systemic chemotherapy alone (n = 78). The 3-year survival rate after surgery of the primary tumor and metastatic disease was 69 %. Resection of the primary tumor was an independent factor for improved survival after occurrence of metastatic disease. Conclusions: Patients with resected localized nonmetastatic hgPNEC and later metastatic disease seemed to benefit from initial resection of the primary tumor. Patients selected for resection of the primary tumor and synchronous liver metastases had a high 3-year survival rate. Selected patients with both localized hgPNEC and metastatic hgPNEC should be considered for radical surgical treatment.

U2 - 10.1245/s10434-015-5013-2

DO - 10.1245/s10434-015-5013-2

M3 - Journal article

C2 - 26678407

AN - SCOPUS:84949938919

SN - 1068-9265

VL - 23

SP - 1721

EP - 1728

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

IS - 5

ER -

Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study

Abstract

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