Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

S G Rønn; A Börjesson; C Bruun; P E Heding; H Frobøse; T Mandrup-Poulsen; A E Karlsen; J Rasschaert; S Sandler; Nils Billestrup

doi:10.1007/s00125-008-1090-0

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

S G Rønn, A Börjesson, C Bruun, P E Heding, H Frobøse, T Mandrup-Poulsen, A E Karlsen, J Rasschaert, S Sandler, Nils Billestrup

Endocrinology and Metabolism

27 Citations (Scopus)

Abstract

The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes mellitus. Suppressor of cytokine signalling (SOCS)-3 inhibits the cytokine-mediated destruction of insulinoma-1 cells. Here we investigate the effect of SOCS3 in primary rodent beta cells and diabetic animal models.

Original language	English
Journal	Diabetologia
Volume	51
Issue number	10
Pages (from-to)	1873-1882
Number of pages	10
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-008-1090-0
Publication status	Published - 2008

Keywords

Alloxan
Animals
Animals, Newborn
Apoptosis
Blotting, Western
Cytokines
Diabetes Mellitus, Experimental
Graft Survival
Humans
In Situ Nick-End Labeling
Islets of Langerhans
Islets of Langerhans Transplantation
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, Transgenic
Rats
Reverse Transcriptase Polymerase Chain Reaction
Suppressor of Cytokine Signaling Proteins
Transplantation, Homologous

UN SDGs

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Rønn, S. G., Börjesson, A., Bruun, C., Heding, P. E., Frobøse, H., Mandrup-Poulsen, T., Karlsen, A. E., Rasschaert, J., Sandler, S., & Billestrup, N. (2008). Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection. Diabetologia, 51(10), 1873-1882. https://doi.org/10.1007/s00125-008-1090-0

Rønn, SG, Börjesson, A, Bruun, C, Heding, PE, Frobøse, H, Mandrup-Poulsen, T, Karlsen, AE, Rasschaert, J, Sandler, S & Billestrup, N 2008, 'Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection', Diabetologia, vol. 51, no. 10, pp. 1873-1882. https://doi.org/10.1007/s00125-008-1090-0

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abstract = "The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes mellitus. Suppressor of cytokine signalling (SOCS)-3 inhibits the cytokine-mediated destruction of insulinoma-1 cells. Here we investigate the effect of SOCS3 in primary rodent beta cells and diabetic animal models.",

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T1 - Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

AU - Rønn, S G

AU - Börjesson, A

AU - Bruun, C

AU - Heding, P E

AU - Frobøse, H

AU - Mandrup-Poulsen, T

AU - Karlsen, A E

AU - Rasschaert, J

AU - Sandler, S

AU - Billestrup, Nils

PY - 2008

Y1 - 2008

N2 - The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes mellitus. Suppressor of cytokine signalling (SOCS)-3 inhibits the cytokine-mediated destruction of insulinoma-1 cells. Here we investigate the effect of SOCS3 in primary rodent beta cells and diabetic animal models.

AB - The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes mellitus. Suppressor of cytokine signalling (SOCS)-3 inhibits the cytokine-mediated destruction of insulinoma-1 cells. Here we investigate the effect of SOCS3 in primary rodent beta cells and diabetic animal models.

KW - Alloxan

KW - Animals

KW - Animals, Newborn

KW - Apoptosis

KW - Blotting, Western

KW - Cytokines

KW - Diabetes Mellitus, Experimental

KW - Graft Survival

KW - Humans

KW - In Situ Nick-End Labeling

KW - Islets of Langerhans

KW - Islets of Langerhans Transplantation

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Inbred NOD

KW - Mice, Transgenic

KW - Rats

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Suppressor of Cytokine Signaling Proteins

KW - Transplantation, Homologous

U2 - 10.1007/s00125-008-1090-0

DO - 10.1007/s00125-008-1090-0

M3 - Journal article

C2 - 18648765

SN - 0012-186X

VL - 51

SP - 1873

EP - 1882

JO - Diabetologia

JF - Diabetologia

IS - 10

ER -

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

Abstract

Keywords

UN SDGs

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