Support of association between BRD1 and both schizophrenia and bipolar affective disorder

TY - JOUR

T1 - Support of association between BRD1 and both schizophrenia and bipolar affective disorder

AU - Nyegaard, Mette

AU - Severinsen, Jacob E

AU - Als, Thomas D

AU - Hedemand, Anne

AU - Straarup, Steen

AU - Nordentoft, Merete

AU - McQuillin, Andrew

AU - Bass, Nicholas

AU - Lawrence, Jacob

AU - Thirumalai, Srinivasa

AU - Pereira, Ana C P

AU - Kandaswamy, Radhika

AU - Lydall, Gregory J

AU - Sklar, Pamela

AU - Scolnick, Edward

AU - Purcell, Shaun

AU - Curtis, David

AU - Gurling, Hugh M D

AU - Mortensen, Preben B

AU - Mors, Ole

AU - Børglum, Anders D

N1 - (c) 2009 Wiley-Liss, Inc.

PY - 2010/3

Y1 - 2010/3

N2 - A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided evidence suggesting a possible role for BRD1 in neurodevelopment. The present study reports an association analysis of BRD1 and the neighboring gene ZBED4 using a Caucasian case - control sample from Denmark and England (UK/DK sample: 490 patients with BPD, 527 patients with SZ, and 601 control individuals), and genotypes obtained from a BPD genome wide association (GWA) study of an overlapping English sample comprising 506 patients with BPD and 510 control individuals (UCL sample). In the UK/DK sample we genotyped 11 SNPs in the BRD1 region, of which six showed association with SZ (minimal single marker P-values of 0.0014), including two SNPs that previously showed association in a Scottish population [Severinsen et al. (2006); Mol Psychiatry 11(12): 1126-1138]. Haplotype analysis revealed specific risk as well as protective haplotypes with a minimal P-value of 0.0027. None of the 11 SNPs showed association with BPD. However, analyzing seven BRD1 SNPs obtained from the BPDGWAstudy, positive associations with BPD was observed with all markers (minimal P-value of 0.0014). The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility.

AB - A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided evidence suggesting a possible role for BRD1 in neurodevelopment. The present study reports an association analysis of BRD1 and the neighboring gene ZBED4 using a Caucasian case - control sample from Denmark and England (UK/DK sample: 490 patients with BPD, 527 patients with SZ, and 601 control individuals), and genotypes obtained from a BPD genome wide association (GWA) study of an overlapping English sample comprising 506 patients with BPD and 510 control individuals (UCL sample). In the UK/DK sample we genotyped 11 SNPs in the BRD1 region, of which six showed association with SZ (minimal single marker P-values of 0.0014), including two SNPs that previously showed association in a Scottish population [Severinsen et al. (2006); Mol Psychiatry 11(12): 1126-1138]. Haplotype analysis revealed specific risk as well as protective haplotypes with a minimal P-value of 0.0027. None of the 11 SNPs showed association with BPD. However, analyzing seven BRD1 SNPs obtained from the BPDGWAstudy, positive associations with BPD was observed with all markers (minimal P-value of 0.0014). The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility.

U2 - 10.1002/ajmg.b.31023

DO - 10.1002/ajmg.b.31023

M3 - Journal article

SN - 1552-4841

VL - 153B

SP - 582

EP - 591

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

IS - 2

ER -