Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects

Elisabet Rytter; Bengt Vessby; Rikard Åsgård; Clara Ersson; Shahnaz Moussavian; Anders Mikael Sjödin; Lilianne Abramsson-Zetterberg; Lennart Möller; Samar Basu

doi:10.3109/10715762.2010.515219

Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects

Elisabet Rytter, Bengt Vessby, Rikard Åsgård, Clara Ersson, Shahnaz Moussavian, Anders Mikael Sjödin, Lilianne Abramsson-Zetterberg, Lennart Möller, Samar Basu

27 Citations (Scopus)

Abstract

The present clinical trial examined the influence of a supplement, containing a combination of antioxidants extracted from fruit, berries and vegetables, on levels of plasma antioxidants (tocopherols, carotenoids and ascorbate), glycaemic control (blood glucose, HbA1c, insulin), oxidative stress biomarkers (F2-isoprostane, malondialdehyd, nitrotyrosine, 8-oxo-7, 8-dihydro-2′-deoxyguanosine, formamidopyrimidine glycosylase sites, frequency of micronucleated erythrocytes) and inflammatory markers (interleukin-6, C-reactive protein, prostaglandin F2α-metabolite) in type 2 diabetes. Forty subjects were randomly assigned to control, single or double dose group and completed the study. In summary, 12 weeks of antioxidant supplementation did neither affect glycaemic control nor the levels of biomarkers of oxidative stress or inflammation, despite substantially increased plasma concentrations of antioxidants. The absence of an effect may be explained by the selected study subjects with relatively well-controlled diabetes, a high intake of fruit and vegetable and levels of plasma antioxidants, biomarkers of oxidative stress and inflammatory markers comparable to those found in healthy subjects.

Original language	English
Journal	Free Radical Research
Volume	44
Issue number	12
Pages (from-to)	1445-1453
Number of pages	9
ISSN	1071-5762
DOIs	https://doi.org/10.3109/10715762.2010.515219
Publication status	Published - Dec 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3109/10715762.2010.515219

Cite this

Rytter, E., Vessby, B., Åsgård, R., Ersson, C., Moussavian, S., Sjödin, A. M., Abramsson-Zetterberg, L., Möller, L., & Basu, S. (2010). Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects. Free Radical Research, 44(12), 1445-1453. https://doi.org/10.3109/10715762.2010.515219

Rytter, E, Vessby, B, Åsgård, R, Ersson, C, Moussavian, S, Sjödin, AM, Abramsson-Zetterberg, L, Möller, L & Basu, S 2010, 'Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects', Free Radical Research, vol. 44, no. 12, pp. 1445-1453. https://doi.org/10.3109/10715762.2010.515219

@article{9f17ab80f6e011dfb6d2000ea68e967b,

title = "Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects",

abstract = "The present clinical trial examined the influence of a supplement, containing a combination of antioxidants extracted from fruit, berries and vegetables, on levels of plasma antioxidants (tocopherols, carotenoids and ascorbate), glycaemic control (blood glucose, HbA1c, insulin), oxidative stress biomarkers (F2-isoprostane, malondialdehyd, nitrotyrosine, 8-oxo-7, 8-dihydro-2′-deoxyguanosine, formamidopyrimidine glycosylase sites, frequency of micronucleated erythrocytes) and inflammatory markers (interleukin-6, C-reactive protein, prostaglandin F2α-metabolite) in type 2 diabetes. Forty subjects were randomly assigned to control, single or double dose group and completed the study. In summary, 12 weeks of antioxidant supplementation did neither affect glycaemic control nor the levels of biomarkers of oxidative stress or inflammation, despite substantially increased plasma concentrations of antioxidants. The absence of an effect may be explained by the selected study subjects with relatively well-controlled diabetes, a high intake of fruit and vegetable and levels of plasma antioxidants, biomarkers of oxidative stress and inflammatory markers comparable to those found in healthy subjects.",

author = "Elisabet Rytter and Bengt Vessby and Rikard {\AA}sg{\aa}rd and Clara Ersson and Shahnaz Moussavian and Sj{\"o}din, {Anders Mikael} and Lilianne Abramsson-Zetterberg and Lennart M{\"o}ller and Samar Basu",

year = "2010",

month = dec,

doi = "10.3109/10715762.2010.515219",

language = "English",

volume = "44",

pages = "1445--1453",

journal = "Free Radical Research",

issn = "1071-5762",

publisher = "Taylor & Francis",

number = "12",

}

TY - JOUR

T1 - Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects

AU - Rytter, Elisabet

AU - Vessby, Bengt

AU - Åsgård, Rikard

AU - Ersson, Clara

AU - Moussavian, Shahnaz

AU - Sjödin, Anders Mikael

AU - Abramsson-Zetterberg, Lilianne

AU - Möller, Lennart

AU - Basu, Samar

PY - 2010/12

Y1 - 2010/12

N2 - The present clinical trial examined the influence of a supplement, containing a combination of antioxidants extracted from fruit, berries and vegetables, on levels of plasma antioxidants (tocopherols, carotenoids and ascorbate), glycaemic control (blood glucose, HbA1c, insulin), oxidative stress biomarkers (F2-isoprostane, malondialdehyd, nitrotyrosine, 8-oxo-7, 8-dihydro-2′-deoxyguanosine, formamidopyrimidine glycosylase sites, frequency of micronucleated erythrocytes) and inflammatory markers (interleukin-6, C-reactive protein, prostaglandin F2α-metabolite) in type 2 diabetes. Forty subjects were randomly assigned to control, single or double dose group and completed the study. In summary, 12 weeks of antioxidant supplementation did neither affect glycaemic control nor the levels of biomarkers of oxidative stress or inflammation, despite substantially increased plasma concentrations of antioxidants. The absence of an effect may be explained by the selected study subjects with relatively well-controlled diabetes, a high intake of fruit and vegetable and levels of plasma antioxidants, biomarkers of oxidative stress and inflammatory markers comparable to those found in healthy subjects.

AB - The present clinical trial examined the influence of a supplement, containing a combination of antioxidants extracted from fruit, berries and vegetables, on levels of plasma antioxidants (tocopherols, carotenoids and ascorbate), glycaemic control (blood glucose, HbA1c, insulin), oxidative stress biomarkers (F2-isoprostane, malondialdehyd, nitrotyrosine, 8-oxo-7, 8-dihydro-2′-deoxyguanosine, formamidopyrimidine glycosylase sites, frequency of micronucleated erythrocytes) and inflammatory markers (interleukin-6, C-reactive protein, prostaglandin F2α-metabolite) in type 2 diabetes. Forty subjects were randomly assigned to control, single or double dose group and completed the study. In summary, 12 weeks of antioxidant supplementation did neither affect glycaemic control nor the levels of biomarkers of oxidative stress or inflammation, despite substantially increased plasma concentrations of antioxidants. The absence of an effect may be explained by the selected study subjects with relatively well-controlled diabetes, a high intake of fruit and vegetable and levels of plasma antioxidants, biomarkers of oxidative stress and inflammatory markers comparable to those found in healthy subjects.

U2 - 10.3109/10715762.2010.515219

DO - 10.3109/10715762.2010.515219

M3 - Journal article

C2 - 20942575

SN - 1071-5762

VL - 44

SP - 1445

EP - 1453

JO - Free Radical Research

JF - Free Radical Research

IS - 12

ER -

Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this