Supplementation of docosahexaenoic acid (DHA), vitamin D3 and uridine in combination with six weeks of cognitive and motor training in prepubescent children: A pilot study

Solvejg Lis Hansen; Anina Ritterband-Rosenbaum; Camilla B Voigt; Lars Hellgren; Ann-Dorit Moltke Sørensen; Charlotte Jacobsen; Line Z Greve; Katrine D Jørgensen; Peder Esben Bilde; Bente Kiens; Jens Bo Nielsen

doi:10.1186/s40795-017-0155-1

Supplementation of docosahexaenoic acid (DHA), vitamin D₃ and uridine in combination with six weeks of cognitive and motor training in prepubescent children: A pilot study

Solvejg Lis Hansen, Anina Ritterband-Rosenbaum, Camilla B Voigt, Lars Hellgren, Ann-Dorit Moltke Sørensen, Charlotte Jacobsen, Line Z Greve, Katrine D Jørgensen, Peder Esben Bilde, Bente Kiens, Jens Bo Nielsen

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Abstract

Background: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect of combining a motor- and cognitive exercise program with dietary supplementation consisting of 500 mg docosahexaenoic acid (DHA), 10 μg vitamin D3 and 1000 mg uridine (DDU-supplement) in 16 prepubescent children (age 8-11 years). Methods: We designed a randomized, placebo-controlled, double-blinded study lasting 6 weeks in which DDU-supplement or placebo was ingested daily. During the intervention period, all children trained approximately 30 min 3 days/week using an internet-based cognitive and motor training program (Mitii). Prior to and post the intervention period dietary record, blood sampling, physical exercise tests and motor and cognitive tests were performed. Results: Fourteen of the 16 children completed the intervention and ingested the supplement as required. 6 weeks DDU-supplementation resulted in a significant increase in the blood concentration of vitamin D2+3 and DHA (p = 0.023 and p < 0.001, respectively). Power calculation based on one of the cognitive tasks revealed a proper sample size of 26 children. Conclusion: All children showed improved performance in the trained motor- and cognitive tasks, but it was not possible to demonstrate any significant effects on the cognitive tests from the dietary supplementation. However, DDU-supplementation did result in increased blood concentration of DHA and vitamin D2+3.

Original language	English
Article number	37
Journal	B M C Nutrition
Volume	3
Number of pages	12
ISSN	2055-0928
DOIs	https://doi.org/10.1186/s40795-017-0155-1
Publication status	Published - 22 Dec 2017

Keywords

Faculty of Science
Nutritional supplement
Training
Children
Blood samples
DHA
Vitamin D
Uridine
Pilot study

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Hansen, S. L., Ritterband-Rosenbaum, A., Voigt, C. B., Hellgren, L., Sørensen, A-D. M., Jacobsen, C., Greve, L. Z., Jørgensen, K. D., Bilde, P. E., Kiens, B., & Nielsen, J. B. (2017). Supplementation of docosahexaenoic acid (DHA), vitamin D₃ and uridine in combination with six weeks of cognitive and motor training in prepubescent children: A pilot study. B M C Nutrition, 3, [37]. https://doi.org/10.1186/s40795-017-0155-1

Supplementation of docosahexaenoic acid (DHA), vitamin D₃ and uridine in combination with six weeks of cognitive and motor training in prepubescent children : A pilot study. / Hansen, Solvejg Lis; Ritterband-Rosenbaum, Anina; Voigt, Camilla B et al.

In: B M C Nutrition, Vol. 3, 37, 22.12.2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Hansen, SL, Ritterband-Rosenbaum, A, Voigt, CB, Hellgren, L, Sørensen, A-DM, Jacobsen, C, Greve, LZ, Jørgensen, KD, Bilde, PE, Kiens, B & Nielsen, JB 2017, 'Supplementation of docosahexaenoic acid (DHA), vitamin D₃ and uridine in combination with six weeks of cognitive and motor training in prepubescent children: A pilot study', B M C Nutrition, vol. 3, 37. https://doi.org/10.1186/s40795-017-0155-1

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title = "Supplementation of docosahexaenoic acid (DHA), vitamin D3 and uridine in combination with six weeks of cognitive and motor training in prepubescent children: A pilot study",

abstract = "Background: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect of combining a motor- and cognitive exercise program with dietary supplementation consisting of 500 mg docosahexaenoic acid (DHA), 10 μg vitamin D3 and 1000 mg uridine (DDU-supplement) in 16 prepubescent children (age 8-11 years). Methods: We designed a randomized, placebo-controlled, double-blinded study lasting 6 weeks in which DDU-supplement or placebo was ingested daily. During the intervention period, all children trained approximately 30 min 3 days/week using an internet-based cognitive and motor training program (Mitii). Prior to and post the intervention period dietary record, blood sampling, physical exercise tests and motor and cognitive tests were performed. Results: Fourteen of the 16 children completed the intervention and ingested the supplement as required. 6 weeks DDU-supplementation resulted in a significant increase in the blood concentration of vitamin D2+3 and DHA (p = 0.023 and p < 0.001, respectively). Power calculation based on one of the cognitive tasks revealed a proper sample size of 26 children. Conclusion: All children showed improved performance in the trained motor- and cognitive tasks, but it was not possible to demonstrate any significant effects on the cognitive tests from the dietary supplementation. However, DDU-supplementation did result in increased blood concentration of DHA and vitamin D2+3. ",

keywords = "Faculty of Science, Nutritional supplement, Training, Children, Blood samples, DHA, Vitamin D, Uridine, Pilot study",

author = "Hansen, {Solvejg Lis} and Anina Ritterband-Rosenbaum and Voigt, {Camilla B} and Lars Hellgren and S{\o}rensen, {Ann-Dorit Moltke} and Charlotte Jacobsen and Greve, {Line Z} and J{\o}rgensen, {Katrine D} and Bilde, {Peder Esben} and Bente Kiens and Nielsen, {Jens Bo}",

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T1 - Supplementation of docosahexaenoic acid (DHA), vitamin D3 and uridine in combination with six weeks of cognitive and motor training in prepubescent children

T2 - A pilot study

AU - Hansen, Solvejg Lis

AU - Ritterband-Rosenbaum, Anina

AU - Voigt, Camilla B

AU - Hellgren, Lars

AU - Sørensen, Ann-Dorit Moltke

AU - Jacobsen, Charlotte

AU - Greve, Line Z

AU - Jørgensen, Katrine D

AU - Bilde, Peder Esben

AU - Kiens, Bente

AU - Nielsen, Jens Bo

N1 - CURIS 2018 NEXS 343

PY - 2017/12/22

Y1 - 2017/12/22

N2 - Background: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect of combining a motor- and cognitive exercise program with dietary supplementation consisting of 500 mg docosahexaenoic acid (DHA), 10 μg vitamin D3 and 1000 mg uridine (DDU-supplement) in 16 prepubescent children (age 8-11 years). Methods: We designed a randomized, placebo-controlled, double-blinded study lasting 6 weeks in which DDU-supplement or placebo was ingested daily. During the intervention period, all children trained approximately 30 min 3 days/week using an internet-based cognitive and motor training program (Mitii). Prior to and post the intervention period dietary record, blood sampling, physical exercise tests and motor and cognitive tests were performed. Results: Fourteen of the 16 children completed the intervention and ingested the supplement as required. 6 weeks DDU-supplementation resulted in a significant increase in the blood concentration of vitamin D2+3 and DHA (p = 0.023 and p < 0.001, respectively). Power calculation based on one of the cognitive tasks revealed a proper sample size of 26 children. Conclusion: All children showed improved performance in the trained motor- and cognitive tasks, but it was not possible to demonstrate any significant effects on the cognitive tests from the dietary supplementation. However, DDU-supplementation did result in increased blood concentration of DHA and vitamin D2+3.

AB - Background: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect of combining a motor- and cognitive exercise program with dietary supplementation consisting of 500 mg docosahexaenoic acid (DHA), 10 μg vitamin D3 and 1000 mg uridine (DDU-supplement) in 16 prepubescent children (age 8-11 years). Methods: We designed a randomized, placebo-controlled, double-blinded study lasting 6 weeks in which DDU-supplement or placebo was ingested daily. During the intervention period, all children trained approximately 30 min 3 days/week using an internet-based cognitive and motor training program (Mitii). Prior to and post the intervention period dietary record, blood sampling, physical exercise tests and motor and cognitive tests were performed. Results: Fourteen of the 16 children completed the intervention and ingested the supplement as required. 6 weeks DDU-supplementation resulted in a significant increase in the blood concentration of vitamin D2+3 and DHA (p = 0.023 and p < 0.001, respectively). Power calculation based on one of the cognitive tasks revealed a proper sample size of 26 children. Conclusion: All children showed improved performance in the trained motor- and cognitive tasks, but it was not possible to demonstrate any significant effects on the cognitive tests from the dietary supplementation. However, DDU-supplementation did result in increased blood concentration of DHA and vitamin D2+3.

KW - Faculty of Science

KW - Nutritional supplement

KW - Training

KW - Children

KW - Blood samples

KW - DHA

KW - Vitamin D

KW - Uridine

KW - Pilot study

U2 - 10.1186/s40795-017-0155-1

DO - 10.1186/s40795-017-0155-1

M3 - Journal article

SN - 2055-0928

VL - 3

JO - BMC Nutrition

JF - BMC Nutrition

M1 - 37

ER -