Superoxide production and expression of NAD(P)H oxidases by transformed and primary human colonic epithelial cells

A Perner, Lars Andresen, G Pedersen, J Rask-Madsen

    54 Citations (Scopus)

    Abstract

    Superoxide (O(2)(-)) generation through the activity of reduced nicotinamide dinucleotide (NADH) or reduced nicotinamide dinucleotide phosphate (NADPH) oxidases has been demonstrated in a variety of cell types, but not in human colonic epithelial cells.
    Original languageEnglish
    JournalGut
    Volume52
    Issue number2
    Pages (from-to)231-6
    Number of pages6
    ISSN0017-5749
    Publication statusPublished - 2003

    Keywords

    • Caco-2 Cells
    • Cell Transformation, Neoplastic
    • Cells, Cultured
    • Colon
    • Colonic Neoplasms
    • Glucose
    • HT29 Cells
    • Humans
    • Hydrogen-Ion Concentration
    • Lactates
    • Membrane Glycoproteins
    • Membrane Transport Proteins
    • Multienzyme Complexes
    • NADH, NADPH Oxidoreductases
    • NADPH Dehydrogenase
    • NADPH Oxidase
    • Neoplasm Proteins
    • Phosphoproteins
    • RNA, Messenger
    • Reverse Transcriptase Polymerase Chain Reaction
    • Superoxides
    • Tumor Cells, Cultured

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