Sudden infant death syndrome (SIDS)--standardised investigations and classification: recommendations

Thomas Bajanowski, Ashild Vege, Roger W Byard, Henry F Krous, Marianne Arnestad, Liliana Bachs, Jytte Banner, Peter S Blair, Arne Borthne, Reinhard Dettmeyer, Peter Fleming, Peter Gaustad, Markil Ebbe Gregers Gregersen, Jens Grøgaard, Ellen Holter, Christina V Isaksen, Jens V Jorgensen, Charlotte de Lange, Burkhard Madea, Isabella MooreJorg Morland, Siri H Opdal, Petra Råsten-Almqvist, Martin Schlaud, Peter Sidebotham, Kari Skullerud, Gisela Stoltenburg-Didinger, Arne Stray-Pedersen, Lisbeth Sveum, Torleiv O Rognum

96 Citations (Scopus)

Abstract

Sudden infant death syndrome (SIDS) still accounts for considerable numbers of unexpected infant deaths in many countries. While numerous theories have been advanced to explain these events, it is increasingly clear that this group of infant deaths results from the complex interaction of a variety of heritable and idiosyncratic endogenous factors interacting with exogenous factors. This has been elegantly summarised in the "three hit" or "triple risk" model. Contradictions and lack of consistencies in the literature have arisen from diverse autopsy approaches, variable applications of diagnostic criteria and inconsistent use of definitions. An approach to sudden infant death is outlined with discussion of appropriate tissue sampling, ancillary investigations and the use of controls in research projects. Standardisation of infant death investigations with the application of uniform definitions and protocols will ensure optimal investigation of individual cases and enable international comparisons of trends.
Original languageEnglish
JournalForensic Science International
Volume165
Issue number2-3
Pages (from-to)129-43
Number of pages15
ISSN0379-0738
DOIs
Publication statusPublished - 17 Jan 2007

Keywords

  • Bacteriological Techniques
  • Central Nervous System
  • Forensic Sciences
  • Humans
  • Immunohistochemistry
  • Infant
  • Myocardium
  • Research Design
  • Respiratory System
  • Sudden Infant Death
  • Virology

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