Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring

Inge Danielsen; Charlotta Granström; Dorte Rytter; Thorhallur I Halldorsson; Bodil Hammer Bech; Tine Brink Henriksen; Coen D A Stehouwer; Casper G Schalkwijk; Allan A Vaag; Sjurdur F Olsen

doi:10.1002/oby.20650

Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring

Inge Danielsen, Charlotta Granström, Dorte Rytter, Thorhallur I Halldorsson, Bodil Hammer Bech, Tine Brink Henriksen, Coen D A Stehouwer, Casper G Schalkwijk, Allan A Vaag, Sjurdur F Olsen

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

OBJECTIVE: Growing evidence indicates that the metabolic syndrome (MS) is rooted in adverse exposures during fetal life. The aim of this study was to assess the possible associations between biomarkers of inflammation during third trimester of pregnancy and markers of MS in adult offspring.

METHODS: High-sensitive C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleuki-6 (IL-6) were measured in serum samples obtained in gestational week 30. Offspring were clinically examined at age 20 years. Analyses based on 439 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, prepregnancy body mass index (BMI), education, and offspring's sex. Offspring MS markers included waist circumference, BMI, blood pressure, HOMA insulin resistance, and plasma levels of fasting glucose, triglycerides, cholesterol fractions, insulin, and leptin.

RESULTS: The median level was 2.8 (interquartile range = 3.3) µg/ml for CRP, for TNF-α: 5.7 (3.2) pg/ml, for IL-1β: 0.5 (0.4) pg/ml, and for IL-6: 1.1 (0.7) pg/ml. Concentrations were not significantly associated with MS markers in the offspring. The results remained essentially unchanged after correction for potential confounding.

CONCLUSION: Markers for subclinical inflammation in third trimester in healthy women were not associated with components of MS in their adult offspring.

Original language	English
Journal	Obesity
Volume	22
Issue number	5
Pages (from-to)	1351-1358
Number of pages	8
ISSN	1930-7381
DOIs	https://doi.org/10.1002/oby.20650
Publication status	Published - May 2014

Keywords

Adult
Biological Markers
Blood Glucose
Blood Pressure
Body Mass Index
C-Reactive Protein
Cholesterol
Female
Follow-Up Studies
Humans
Inflammation
Insulin
Insulin Resistance
Interleukin-1beta
Interleukin-6
Leptin
Linear Models
Longitudinal Studies
Male
Metabolic Syndrome X
Multivariate Analysis
Pregnancy
Pregnancy Trimester, Third
Triglycerides
Tumor Necrosis Factor-alpha
Waist Circumference
Young Adult

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Danielsen, I., Granström, C., Rytter, D., Halldorsson, T. I., Bech, B. H., Henriksen, T. B., Stehouwer, C. D. A., Schalkwijk, C. G., Vaag, A. A., & Olsen, S. F. (2014). Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring. Obesity, 22(5), 1351-1358. https://doi.org/10.1002/oby.20650

@article{379ff3c769394f79931630b63914bce3,

title = "Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring",

abstract = "OBJECTIVE: Growing evidence indicates that the metabolic syndrome (MS) is rooted in adverse exposures during fetal life. The aim of this study was to assess the possible associations between biomarkers of inflammation during third trimester of pregnancy and markers of MS in adult offspring.METHODS: High-sensitive C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleuki-6 (IL-6) were measured in serum samples obtained in gestational week 30. Offspring were clinically examined at age 20 years. Analyses based on 439 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, prepregnancy body mass index (BMI), education, and offspring's sex. Offspring MS markers included waist circumference, BMI, blood pressure, HOMA insulin resistance, and plasma levels of fasting glucose, triglycerides, cholesterol fractions, insulin, and leptin.RESULTS: The median level was 2.8 (interquartile range = 3.3) µg/ml for CRP, for TNF-α: 5.7 (3.2) pg/ml, for IL-1β: 0.5 (0.4) pg/ml, and for IL-6: 1.1 (0.7) pg/ml. Concentrations were not significantly associated with MS markers in the offspring. The results remained essentially unchanged after correction for potential confounding.CONCLUSION: Markers for subclinical inflammation in third trimester in healthy women were not associated with components of MS in their adult offspring.",

keywords = "Adult, Biological Markers, Blood Glucose, Blood Pressure, Body Mass Index, C-Reactive Protein, Cholesterol, Female, Follow-Up Studies, Humans, Inflammation, Insulin, Insulin Resistance, Interleukin-1beta, Interleukin-6, Leptin, Linear Models, Longitudinal Studies, Male, Metabolic Syndrome X, Multivariate Analysis, Pregnancy, Pregnancy Trimester, Third, Triglycerides, Tumor Necrosis Factor-alpha, Waist Circumference, Young Adult",

author = "Inge Danielsen and Charlotta Granstr{\"o}m and Dorte Rytter and Halldorsson, {Thorhallur I} and Bech, {Bodil Hammer} and Henriksen, {Tine Brink} and Stehouwer, {Coen D A} and Schalkwijk, {Casper G} and Vaag, {Allan A} and Olsen, {Sjurdur F}",

note = "Copyright {\textcopyright} 2013 The Obesity Society.",

year = "2014",

month = may,

doi = "10.1002/oby.20650",

language = "English",

volume = "22",

pages = "1351--1358",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring

AU - Danielsen, Inge

AU - Granström, Charlotta

AU - Rytter, Dorte

AU - Halldorsson, Thorhallur I

AU - Bech, Bodil Hammer

AU - Henriksen, Tine Brink

AU - Stehouwer, Coen D A

AU - Schalkwijk, Casper G

AU - Vaag, Allan A

AU - Olsen, Sjurdur F

PY - 2014/5

Y1 - 2014/5

N2 - OBJECTIVE: Growing evidence indicates that the metabolic syndrome (MS) is rooted in adverse exposures during fetal life. The aim of this study was to assess the possible associations between biomarkers of inflammation during third trimester of pregnancy and markers of MS in adult offspring.METHODS: High-sensitive C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleuki-6 (IL-6) were measured in serum samples obtained in gestational week 30. Offspring were clinically examined at age 20 years. Analyses based on 439 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, prepregnancy body mass index (BMI), education, and offspring's sex. Offspring MS markers included waist circumference, BMI, blood pressure, HOMA insulin resistance, and plasma levels of fasting glucose, triglycerides, cholesterol fractions, insulin, and leptin.RESULTS: The median level was 2.8 (interquartile range = 3.3) µg/ml for CRP, for TNF-α: 5.7 (3.2) pg/ml, for IL-1β: 0.5 (0.4) pg/ml, and for IL-6: 1.1 (0.7) pg/ml. Concentrations were not significantly associated with MS markers in the offspring. The results remained essentially unchanged after correction for potential confounding.CONCLUSION: Markers for subclinical inflammation in third trimester in healthy women were not associated with components of MS in their adult offspring.

AB - OBJECTIVE: Growing evidence indicates that the metabolic syndrome (MS) is rooted in adverse exposures during fetal life. The aim of this study was to assess the possible associations between biomarkers of inflammation during third trimester of pregnancy and markers of MS in adult offspring.METHODS: High-sensitive C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleuki-6 (IL-6) were measured in serum samples obtained in gestational week 30. Offspring were clinically examined at age 20 years. Analyses based on 439 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, prepregnancy body mass index (BMI), education, and offspring's sex. Offspring MS markers included waist circumference, BMI, blood pressure, HOMA insulin resistance, and plasma levels of fasting glucose, triglycerides, cholesterol fractions, insulin, and leptin.RESULTS: The median level was 2.8 (interquartile range = 3.3) µg/ml for CRP, for TNF-α: 5.7 (3.2) pg/ml, for IL-1β: 0.5 (0.4) pg/ml, and for IL-6: 1.1 (0.7) pg/ml. Concentrations were not significantly associated with MS markers in the offspring. The results remained essentially unchanged after correction for potential confounding.CONCLUSION: Markers for subclinical inflammation in third trimester in healthy women were not associated with components of MS in their adult offspring.

KW - Adult

KW - Biological Markers

KW - Blood Glucose

KW - Blood Pressure

KW - Body Mass Index

KW - C-Reactive Protein

KW - Cholesterol

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Inflammation

KW - Insulin

KW - Insulin Resistance

KW - Interleukin-1beta

KW - Interleukin-6

KW - Leptin

KW - Linear Models

KW - Longitudinal Studies

KW - Male

KW - Metabolic Syndrome X

KW - Multivariate Analysis

KW - Pregnancy

KW - Pregnancy Trimester, Third

KW - Triglycerides

KW - Tumor Necrosis Factor-alpha

KW - Waist Circumference

KW - Young Adult

U2 - 10.1002/oby.20650

DO - 10.1002/oby.20650

M3 - Journal article

C2 - 24167021

SN - 1930-7381

VL - 22

SP - 1351

EP - 1358

JO - Obesity

JF - Obesity

IS - 5

ER -

Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring

Abstract

Keywords

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