TY - JOUR
T1 - Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice
AU - Wellner, Niels
AU - Tsuboi, Kazuhito
AU - Madsen, Andreas Nygaard
AU - Holst, Birgitte
AU - Diep, Thi Ai
AU - Nakao, Michiyasu
AU - Tokumura, Akira
AU - Burns, Matthew P
AU - Deutsch, Dale G
AU - Ueda, Natsuo
AU - Hansen, Harald Severin
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2011/9/1
Y1 - 2011/9/1
N2 - N-acyl-phosphatidylethanolamine is a precursor phospholipid for anandamide, oleoylethanolamide, and other N-acylethanolamines, and it may in itself have biological functions in cell membranes. Recently, N-palmitoyl-phosphatidylethanolamine (NAPE) has been reported to function as an anorectic hormone secreted from the gut and acting on the brain (Gillum et al., [5]). In the current study, two of our laboratories independently investigated whether NAPE metabolites may be involved in mediating the anorectic action of NAPE i.p. injected in mice. Thus, the anorectic activity of a non-hydrolysable NAPE analogue, having ether bonds instead of ester bonds at sn1 and sn2 was compared with that of NAPE in molar equivalent doses. Furthermore, the anorectic effect of NAPE in NAPE-hydrolysing phospholipase D knockout animals was investigated. As negative controls, the NAPE precursor phosphatidylethanolamine and the related phospholipids phosphatidylcholine and phosphatidic acid were also tested. All compounds except one were found to inhibit food intake, raising the possibility that the effect of NAPE is non-specific.
AB - N-acyl-phosphatidylethanolamine is a precursor phospholipid for anandamide, oleoylethanolamide, and other N-acylethanolamines, and it may in itself have biological functions in cell membranes. Recently, N-palmitoyl-phosphatidylethanolamine (NAPE) has been reported to function as an anorectic hormone secreted from the gut and acting on the brain (Gillum et al., [5]). In the current study, two of our laboratories independently investigated whether NAPE metabolites may be involved in mediating the anorectic action of NAPE i.p. injected in mice. Thus, the anorectic activity of a non-hydrolysable NAPE analogue, having ether bonds instead of ester bonds at sn1 and sn2 was compared with that of NAPE in molar equivalent doses. Furthermore, the anorectic effect of NAPE in NAPE-hydrolysing phospholipase D knockout animals was investigated. As negative controls, the NAPE precursor phosphatidylethanolamine and the related phospholipids phosphatidylcholine and phosphatidic acid were also tested. All compounds except one were found to inhibit food intake, raising the possibility that the effect of NAPE is non-specific.
U2 - 10.1016/j.bbalip.2011.06.020
DO - 10.1016/j.bbalip.2011.06.020
M3 - Journal article
C2 - 21723414
SN - 0304-4165
VL - 1811
SP - 508
EP - 512
JO - BBA General Subjects
JF - BBA General Subjects
IS - 9
ER -