Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

G Andersen; J Overgaard; Anders Albrechtsen; C Glümer; K Borch-Johnsen; T Jørgensen; T Hansen; O Pedersen

doi:10.1007/s00125-005-0049-7

Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

G Andersen, J Overgaard, Anders Albrechtsen, C Glümer, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen

38 Citations (Scopus)

Abstract

The 825C>T polymorphism in the gene encoding the G protein beta3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome.

Original language	English
Journal	Diabetologia
Volume	49
Issue number	1
Pages (from-to)	75-82
Number of pages	8
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-005-0049-7
Publication status	Published - Jan 2006

Keywords

Adult
Blood Glucose
Denmark
European Continental Ancestry Group
Fasting
Female
Genotype
Glucose Tolerance Test
Heterotrimeric GTP-Binding Proteins
Humans
Hypertension
Male
Metabolic Syndrome X
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00125-005-0049-7

Cite this

@article{4b96f125fed8455da557ad1f92cd3439,

title = "Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes",

abstract = "The 825C>T polymorphism in the gene encoding the G protein beta3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome.",

keywords = "Adult, Blood Glucose, Denmark, European Continental Ancestry Group, Fasting, Female, Genotype, Glucose Tolerance Test, Heterotrimeric GTP-Binding Proteins, Humans, Hypertension, Male, Metabolic Syndrome X, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors",

author = "G Andersen and J Overgaard and Anders Albrechtsen and C Gl{\"u}mer and K Borch-Johnsen and T J{\o}rgensen and T Hansen and O Pedersen",

year = "2006",

month = jan,

doi = "10.1007/s00125-005-0049-7",

language = "English",

volume = "49",

pages = "75--82",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

AU - Andersen, G

AU - Overgaard, J

AU - Albrechtsen, Anders

AU - Glümer, C

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Hansen, T

AU - Pedersen, O

PY - 2006/1

Y1 - 2006/1

N2 - The 825C>T polymorphism in the gene encoding the G protein beta3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome.

AB - The 825C>T polymorphism in the gene encoding the G protein beta3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome.

KW - Adult

KW - Blood Glucose

KW - Denmark

KW - European Continental Ancestry Group

KW - Fasting

KW - Female

KW - Genotype

KW - Glucose Tolerance Test

KW - Heterotrimeric GTP-Binding Proteins

KW - Humans

KW - Hypertension

KW - Male

KW - Metabolic Syndrome X

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

U2 - 10.1007/s00125-005-0049-7

DO - 10.1007/s00125-005-0049-7

M3 - Journal article

C2 - 16284746

SN - 0012-186X

VL - 49

SP - 75

EP - 82

JO - Diabetologia

JF - Diabetologia

IS - 1

ER -

Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this