Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Thomas Sparsø; Meena Shaheen Hussain; Knut Borch-Johnsen; Torben Jørgensen; Sten Madsbad; Torben Hansen; Oluf Pedersen; Gitte Andersen

doi:10.1016/j.ymgme.2007.06.011

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Thomas Sparsø, Meena Shaheen Hussain, Knut Borch-Johnsen, Torben Jørgensen, Sten Madsbad, Torben Hansen, Oluf Pedersen, Gitte Andersen

2 Citations (Scopus)

Abstract

Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.

Original language	English
Journal	Molecular Genetics and Metabolism
Volume	92
Issue number	3
Pages (from-to)	278-282
Number of pages	5
ISSN	1096-7192
DOIs	https://doi.org/10.1016/j.ymgme.2007.06.011
Publication status	Published - 2007

Keywords

Blood Glucose
Calcium-Binding Proteins
Case-Control Studies
Denmark
Diabetes Mellitus, Type 2
Dyslipidemias
Ethnic Groups
European Continental Ancestry Group
Female
Gene Frequency
Genotype
Glucose Tolerance Test
Humans
Insulin
Male
Middle Aged
Mitochondrial Proteins
Obesity
Polymorphism, Single Nucleotide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ymgme.2007.06.011

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Sparsø, T., Hussain, M. S., Borch-Johnsen, K., Jørgensen, T., Madsbad, S., Hansen, T., Pedersen, O., & Andersen, G. (2007). Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites. Molecular Genetics and Metabolism, 92(3), 278-282. https://doi.org/10.1016/j.ymgme.2007.06.011

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites. / Sparsø, Thomas; Hussain, Meena Shaheen; Borch-Johnsen, Knut et al.

In: Molecular Genetics and Metabolism, Vol. 92, No. 3, 2007, p. 278-282.

Research output: Contribution to journal › Journal article › Research › peer-review

Sparsø, T, Hussain, MS, Borch-Johnsen, K, Jørgensen, T, Madsbad, S , Hansen, T , Pedersen, O & Andersen, G 2007, 'Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites', Molecular Genetics and Metabolism, vol. 92, no. 3, pp. 278-282. https://doi.org/10.1016/j.ymgme.2007.06.011

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abstract = "Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.",

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AU - Sparsø, Thomas

AU - Hussain, Meena Shaheen

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Madsbad, Sten

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Andersen, Gitte

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N2 - Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.

AB - Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells. In previous human association studies the results have been contradictory regarding the association between a CASQ1 rs2275703 polymorphism and type 2 diabetes. In the present study of the CASQ1 rs2275703 polymorphism in 7,088 Danish whites the allele frequency and genotype distribution did not differ between type 2 diabetic patients and glucose-tolerant control subjects, neither was found any association with diabetes-related quantitative traits.

KW - Blood Glucose

KW - Calcium-Binding Proteins

KW - Case-Control Studies

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Dyslipidemias

KW - Ethnic Groups

KW - European Continental Ancestry Group

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Mitochondrial Proteins

KW - Obesity

KW - Polymorphism, Single Nucleotide

U2 - 10.1016/j.ymgme.2007.06.011

DO - 10.1016/j.ymgme.2007.06.011

M3 - Journal article

C2 - 17681849

SN - 1096-7192

VL - 92

SP - 278

EP - 282

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

IS - 3

ER -

Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites

Abstract

Keywords

UN SDGs

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