Structure of a G-protein-coupling domain of a muscarinic receptor predicted by random saturation mutagenesis

Medicine & Life Sciences

• Muscarinic Receptors 87%
• Protein Domains 80%
• GTP-Binding Proteins 79%
• Mutagenesis 79%
• Muscarinic M5 Receptors 35%
• Amino Acids 28%
• NIH 3T3 Cells 25%
• Phenotype 24%
• alpha-Helical Protein Conformation 23%
• Amino Acid Substitution 21%
• Proline 21%
• Alanine 20%
• Arginine 18%
• Ligands 14%
• Mutation 11%

Chemical Compounds

• Parasympathomimetic Agent 100%
• Substitution Reaction 50%
• Radical Substitution 42%
• Acid 27%
• Proline 27%
• Arginine 26%
• Alanine 25%
• Alpha-Helix 25%
• Mutation 22%
• Chemical Transformation 16%