Structure and Function of Cu(I)- and Zn(II)-ATPases

Oleg Sitsel; Christina Grønberg; Henriette Elisabeth Autzen; Kaituo Wang; Gabriele Meloni; Poul Nissen; Pontus Gourdon

doi:10.1021/acs.biochem.5b00512

Structure and Function of Cu(I)- and Zn(II)-ATPases

Oleg Sitsel, Christina Grønberg, Henriette Elisabeth Autzen, Kaituo Wang, Gabriele Meloni, Poul Nissen, Pontus Gourdon

28 Citations (Scopus)

Abstract

Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.

Original language	English
Journal	Biochemistry
Volume	54
Issue number	37
Pages (from-to)	5673-5683
Number of pages	11
ISSN	0006-2960
DOIs	https://doi.org/10.1021/acs.biochem.5b00512
Publication status	Published - 22 Sept 2015

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title = "Structure and Function of Cu(I)- and Zn(II)-ATPases",

abstract = "Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.",

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T1 - Structure and Function of Cu(I)- and Zn(II)-ATPases

AU - Sitsel, Oleg

AU - Grønberg, Christina

AU - Autzen, Henriette Elisabeth

AU - Wang, Kaituo

AU - Meloni, Gabriele

AU - Nissen, Poul

AU - Gourdon, Pontus

PY - 2015/9/22

Y1 - 2015/9/22

N2 - Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.

AB - Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.

U2 - 10.1021/acs.biochem.5b00512

DO - 10.1021/acs.biochem.5b00512

M3 - Journal article

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SN - 0006-2960

VL - 54

SP - 5673

EP - 5683

JO - Biochemistry

JF - Biochemistry

IS - 37

ER -

Structure and Function of Cu(I)- and Zn(II)-ATPases

Abstract

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