Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida

TY - JOUR

T1 - Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida

AU - Sittie, A A

AU - Lemmich, E

AU - Olsen, C E

AU - Hviid, L

AU - Kharazmi, A

AU - Nkrumah, F K

AU - Christensen, S B

N1 - Keywords: Animals; Anthraquinones; Antimalarials; Antiprotozoal Agents; Leishmania major; Plasmodium falciparum; Rubiaceae; Structure-Activity Relationship

PY - 1999

Y1 - 1999

N2 - Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Leishmania major in vitro.

AB - Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Leishmania major in vitro.

M3 - Journal article

C2 - 10232074

SN - 0032-0943

VL - 65

SP - 259

EP - 261

JO - Planta Medica

JF - Planta Medica

IS - 3

ER -