Structural brain abnormalities in early onset first-episode psychosis

A K Pagsberg; W F C Baaré; A M Raabjerg Christensen; B Fagerlund; M-B Hansen; J Labianca; K Krabbe; T Aarkrog; O B Paulson; R P Hemmingsen; M-B Hansen; K Krabbe

doi:10.1007/s00702-006-0573-8

Structural brain abnormalities in early onset first-episode psychosis

A K Pagsberg, W F C Baaré, A M Raabjerg Christensen, B Fagerlund, M-B Hansen, J Labianca, K Krabbe, T Aarkrog, O B Paulson, R P Hemmingsen, M-B Hansen, K Krabbe

31 Citations (Scopus)

Abstract

BACKGROUND: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations. METHODS: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry. RESULTS: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed. Post hoc analyses revealed that schizophrenia patients (n = 15) had significantly larger lateral ventricles as compared to controls. Duration and dose of antipsychotics correlated negatively with global gray matter volume in minimally medicated patients (n = 18). CONCLUSION: Findings of white matter changes and enlarged lateral ventricles already at illness onset in young schizophrenia spectrum patients, suggests aberrant neurodevelopmental processes in the pathogenesis of these disorders. Gray matter volume changes, however, appear not to be a key feature in early onset first-episode psychosis.

Original language	English
Journal	Journal of Neural Transmission
Volume	114
Issue number	4
Pages (from-to)	489-98
Number of pages	10
ISSN	0300-9564
DOIs	https://doi.org/10.1007/s00702-006-0573-8
Publication status	Published - 1 Jan 2007

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title = "Structural brain abnormalities in early onset first-episode psychosis",

abstract = "BACKGROUND: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations. METHODS: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry. RESULTS: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed. Post hoc analyses revealed that schizophrenia patients (n = 15) had significantly larger lateral ventricles as compared to controls. Duration and dose of antipsychotics correlated negatively with global gray matter volume in minimally medicated patients (n = 18). CONCLUSION: Findings of white matter changes and enlarged lateral ventricles already at illness onset in young schizophrenia spectrum patients, suggests aberrant neurodevelopmental processes in the pathogenesis of these disorders. Gray matter volume changes, however, appear not to be a key feature in early onset first-episode psychosis.",

author = "Pagsberg, {A K} and Baar{\'e}, {W F C} and {Raabjerg Christensen}, {A M} and B Fagerlund and M-B Hansen and J Labianca and K Krabbe and T Aarkrog and Paulson, {O B} and Hemmingsen, {R P} and M-B Hansen and K Krabbe",

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doi = "10.1007/s00702-006-0573-8",

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T1 - Structural brain abnormalities in early onset first-episode psychosis

AU - Pagsberg, A K

AU - Baaré, W F C

AU - Raabjerg Christensen, A M

AU - Fagerlund, B

AU - Hansen, M-B

AU - Labianca, J

AU - Krabbe, K

AU - Aarkrog, T

AU - Paulson, O B

AU - Hemmingsen, R P

AU - Hansen, M-B

AU - Krabbe, K

PY - 2007/1/1

Y1 - 2007/1/1

N2 - BACKGROUND: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations. METHODS: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry. RESULTS: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed. Post hoc analyses revealed that schizophrenia patients (n = 15) had significantly larger lateral ventricles as compared to controls. Duration and dose of antipsychotics correlated negatively with global gray matter volume in minimally medicated patients (n = 18). CONCLUSION: Findings of white matter changes and enlarged lateral ventricles already at illness onset in young schizophrenia spectrum patients, suggests aberrant neurodevelopmental processes in the pathogenesis of these disorders. Gray matter volume changes, however, appear not to be a key feature in early onset first-episode psychosis.

AB - BACKGROUND: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations. METHODS: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry. RESULTS: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed. Post hoc analyses revealed that schizophrenia patients (n = 15) had significantly larger lateral ventricles as compared to controls. Duration and dose of antipsychotics correlated negatively with global gray matter volume in minimally medicated patients (n = 18). CONCLUSION: Findings of white matter changes and enlarged lateral ventricles already at illness onset in young schizophrenia spectrum patients, suggests aberrant neurodevelopmental processes in the pathogenesis of these disorders. Gray matter volume changes, however, appear not to be a key feature in early onset first-episode psychosis.

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DO - 10.1007/s00702-006-0573-8

M3 - Journal article

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VL - 114

SP - 489

EP - 498

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 4

ER -

Structural brain abnormalities in early onset first-episode psychosis

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