Stratum corneum damage and ex vivo porcine skin water absorption - a pilot study

C Duch Lynggaard; D Bang Knudsen; G B E Jemec

doi:10.1159/000241298

Stratum corneum damage and ex vivo porcine skin water absorption - a pilot study

C Duch Lynggaard, D Bang Knudsen, G B E Jemec

3 Citations (Scopus)

Abstract

A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

Original language	English
Journal	Skin Pharmacology and Physiology (Print)
Volume	22
Issue number	6
Pages (from-to)	295-8
Number of pages	4
ISSN	1660-5527
DOIs	https://doi.org/10.1159/000241298
Publication status	Published - 2009

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10.1159/000241298

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title = "Stratum corneum damage and ex vivo porcine skin water absorption - a pilot study",

abstract = "A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.",

author = "{Duch Lynggaard}, C and {Bang Knudsen}, D and Jemec, {G B E}",

note = "Keywords: Animals; Models, Animal; Pilot Projects; Skin; Skin Absorption; Skin Irritancy Tests; Swine; Water",

year = "2009",

doi = "10.1159/000241298",

language = "English",

volume = "22",

pages = "295--8",

journal = "Skin Pharmacology and Physiology",

issn = "1660-5527",

publisher = "S Karger AG",

number = "6",

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T1 - Stratum corneum damage and ex vivo porcine skin water absorption - a pilot study

AU - Duch Lynggaard, C

AU - Bang Knudsen, D

AU - Jemec, G B E

N1 - Keywords: Animals; Models, Animal; Pilot Projects; Skin; Skin Absorption; Skin Irritancy Tests; Swine; Water

PY - 2009

Y1 - 2009

N2 - A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

AB - A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

U2 - 10.1159/000241298

DO - 10.1159/000241298

M3 - Journal article

C2 - 19786822

SN - 1660-5527

VL - 22

SP - 295

EP - 298

JO - Skin Pharmacology and Physiology

JF - Skin Pharmacology and Physiology

IS - 6

ER -

Stratum corneum damage and ex vivo porcine skin water absorption - a pilot study

Abstract

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