Spontaneous high frequency diameter oscillations of larger retinal arterioles are reduced in type 2 diabetes mellitus

Toke Bek; Peter Friis Jeppesen; Jørgen K. Kanters

doi:10.1167/iovs.12-11182

Spontaneous high frequency diameter oscillations of larger retinal arterioles are reduced in type 2 diabetes mellitus

Toke Bek, Peter Friis Jeppesen, Jørgen K. Kanters

Physiology of circulation, kidney and lung

24 Citations (Scopus)

Abstract

PURPOSE. Diabetic retinopathy is characterized by morphological changes in the retina secondary to disturbances in retinal blood flow. Vasomotion is a mechanism for regulating blood flow by spontaneous oscillations in the diameter of retinal resistance arterioles, and has been shown to be disturbed outside the eye in diabetic patients. Therefore, the purpose of the present study was to characterize spontaneous oscillations in the diameter of retinal arterioles in normal persons and in persons with different severity of diabetic retinopathy. METHODS. Video recordings of the retina were performed in 19 normal persons and three matched groups of type 2 diabetic patients with no retinopathy, mild retinopathy, and diabetic maculopathy. Continuous recordings of a larger retinal arteriole during rest and during an increase in the arterial blood pressure induced by isometric exercise were subjected to power spectrum analysis of spontaneous oscillations in vessel diameter. RESULTS. During rest the oscillations in the diameter of retinal arterioles with high frequencies were significantly reduced in patients with diabetic retinopathy. Increased arterial blood pressure did not change the oscillations in normal persons, but further reduced the oscillations in diabetic patients. CONCLUSIONS. Spontaneous high frequency oscillations in the diameter of larger retinal arterioles are reduced in type 2 diabetic patients, and are further reduced during an increase in the arterial blood pressure. The finding may reflect changes in the vascular walls of importance for diagnosing and predicting the visual prognosis in patients with diabetic retinopathy.

Original language	English
Journal	Investigative Ophthalmology & Visual Science
Volume	54
Issue number	1
Pages (from-to)	636-40
Number of pages	5
ISSN	0146-0404
DOIs	https://doi.org/10.1167/iovs.12-11182
Publication status	Published - 21 Jan 2013

Keywords

Arterioles
Blood Flow Velocity
Blood Pressure
Diabetes Mellitus, Type 2
Diabetic Retinopathy
Exercise
Female
Heart Rate
Homeostasis
Humans
Male
Middle Aged
Regional Blood Flow
Retinal Artery
Vasodilation
Video Recording

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10.1167/iovs.12-11182

https://iovs.arvojournals.org/data/journals/iovs/933466/i1552-5783-54-1-636.pdf

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title = "Spontaneous high frequency diameter oscillations of larger retinal arterioles are reduced in type 2 diabetes mellitus",

abstract = "PURPOSE. Diabetic retinopathy is characterized by morphological changes in the retina secondary to disturbances in retinal blood flow. Vasomotion is a mechanism for regulating blood flow by spontaneous oscillations in the diameter of retinal resistance arterioles, and has been shown to be disturbed outside the eye in diabetic patients. Therefore, the purpose of the present study was to characterize spontaneous oscillations in the diameter of retinal arterioles in normal persons and in persons with different severity of diabetic retinopathy. METHODS. Video recordings of the retina were performed in 19 normal persons and three matched groups of type 2 diabetic patients with no retinopathy, mild retinopathy, and diabetic maculopathy. Continuous recordings of a larger retinal arteriole during rest and during an increase in the arterial blood pressure induced by isometric exercise were subjected to power spectrum analysis of spontaneous oscillations in vessel diameter. RESULTS. During rest the oscillations in the diameter of retinal arterioles with high frequencies were significantly reduced in patients with diabetic retinopathy. Increased arterial blood pressure did not change the oscillations in normal persons, but further reduced the oscillations in diabetic patients. CONCLUSIONS. Spontaneous high frequency oscillations in the diameter of larger retinal arterioles are reduced in type 2 diabetic patients, and are further reduced during an increase in the arterial blood pressure. The finding may reflect changes in the vascular walls of importance for diagnosing and predicting the visual prognosis in patients with diabetic retinopathy.",

keywords = "Arterioles, Blood Flow Velocity, Blood Pressure, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Exercise, Female, Heart Rate, Homeostasis, Humans, Male, Middle Aged, Regional Blood Flow, Retinal Artery, Vasodilation, Video Recording",

author = "Toke Bek and Jeppesen, {Peter Friis} and Kanters, {J{\o}rgen K.}",

year = "2013",

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doi = "10.1167/iovs.12-11182",

language = "English",

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journal = "Investigative Ophthalmology & Visual Science",

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T1 - Spontaneous high frequency diameter oscillations of larger retinal arterioles are reduced in type 2 diabetes mellitus

AU - Bek, Toke

AU - Jeppesen, Peter Friis

AU - Kanters, Jørgen K.

PY - 2013/1/21

Y1 - 2013/1/21

N2 - PURPOSE. Diabetic retinopathy is characterized by morphological changes in the retina secondary to disturbances in retinal blood flow. Vasomotion is a mechanism for regulating blood flow by spontaneous oscillations in the diameter of retinal resistance arterioles, and has been shown to be disturbed outside the eye in diabetic patients. Therefore, the purpose of the present study was to characterize spontaneous oscillations in the diameter of retinal arterioles in normal persons and in persons with different severity of diabetic retinopathy. METHODS. Video recordings of the retina were performed in 19 normal persons and three matched groups of type 2 diabetic patients with no retinopathy, mild retinopathy, and diabetic maculopathy. Continuous recordings of a larger retinal arteriole during rest and during an increase in the arterial blood pressure induced by isometric exercise were subjected to power spectrum analysis of spontaneous oscillations in vessel diameter. RESULTS. During rest the oscillations in the diameter of retinal arterioles with high frequencies were significantly reduced in patients with diabetic retinopathy. Increased arterial blood pressure did not change the oscillations in normal persons, but further reduced the oscillations in diabetic patients. CONCLUSIONS. Spontaneous high frequency oscillations in the diameter of larger retinal arterioles are reduced in type 2 diabetic patients, and are further reduced during an increase in the arterial blood pressure. The finding may reflect changes in the vascular walls of importance for diagnosing and predicting the visual prognosis in patients with diabetic retinopathy.

AB - PURPOSE. Diabetic retinopathy is characterized by morphological changes in the retina secondary to disturbances in retinal blood flow. Vasomotion is a mechanism for regulating blood flow by spontaneous oscillations in the diameter of retinal resistance arterioles, and has been shown to be disturbed outside the eye in diabetic patients. Therefore, the purpose of the present study was to characterize spontaneous oscillations in the diameter of retinal arterioles in normal persons and in persons with different severity of diabetic retinopathy. METHODS. Video recordings of the retina were performed in 19 normal persons and three matched groups of type 2 diabetic patients with no retinopathy, mild retinopathy, and diabetic maculopathy. Continuous recordings of a larger retinal arteriole during rest and during an increase in the arterial blood pressure induced by isometric exercise were subjected to power spectrum analysis of spontaneous oscillations in vessel diameter. RESULTS. During rest the oscillations in the diameter of retinal arterioles with high frequencies were significantly reduced in patients with diabetic retinopathy. Increased arterial blood pressure did not change the oscillations in normal persons, but further reduced the oscillations in diabetic patients. CONCLUSIONS. Spontaneous high frequency oscillations in the diameter of larger retinal arterioles are reduced in type 2 diabetic patients, and are further reduced during an increase in the arterial blood pressure. The finding may reflect changes in the vascular walls of importance for diagnosing and predicting the visual prognosis in patients with diabetic retinopathy.

KW - Arterioles

KW - Blood Flow Velocity

KW - Blood Pressure

KW - Diabetes Mellitus, Type 2

KW - Diabetic Retinopathy

KW - Exercise

KW - Female

KW - Heart Rate

KW - Homeostasis

KW - Humans

KW - Male

KW - Middle Aged

KW - Regional Blood Flow

KW - Retinal Artery

KW - Vasodilation

KW - Video Recording

U2 - 10.1167/iovs.12-11182

DO - 10.1167/iovs.12-11182

M3 - Journal article

C2 - 23258153

SN - 0146-0404

VL - 54

SP - 636

EP - 640

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

IS - 1

ER -

Spontaneous high frequency diameter oscillations of larger retinal arterioles are reduced in type 2 diabetes mellitus

Abstract

Keywords

UN SDGs

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