Spatial QRS-T angle variants for prediction of all-cause mortality

TY - JOUR

T1 - Spatial QRS-T angle variants for prediction of all-cause mortality

AU - Kück, Karina

AU - Isaksen, Jonas L

AU - Graff, Claus

AU - Skaaby, Tea

AU - Linneberg, Allan

AU - Hansen, Torben

AU - Kanters, Jørgen K

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Many variants of the spatial QRS-T angle (QRS-Ta) are in use. We aimed to identify the best QRS-Ta for all-cause mortality prediction among different variants.METHODS: 6667 individuals from the Inter99 General Population Study were followed for a median of 12.7 years. Vectorcardiograms were calculated using the Kors and Inverse Dower matrices. The QRS-Ta was calculated using both mean and peak vectors of the QRS- and T-loops. Hazard ratios (HR) for abnormal QRS-Tas were calculated using a Cox's Proportional Hazard Model.RESULTS: The highest HR and largest AUC for all-cause mortality was obtained with the Kors matrix and the mean vector (HR = 2.2, 95% confidence interval: [1.38;3.43] p < 0.001, in men). There was interaction with the orientation of the QRS-T plane.CONCLUSION: For optimal prediction of all-cause mortality, the mean vectors in the QRS- and T-loops of the Kors-derived vectorcardiogram should be used. QRS-T plane orientation affects mortality prediction.

AB - BACKGROUND: Many variants of the spatial QRS-T angle (QRS-Ta) are in use. We aimed to identify the best QRS-Ta for all-cause mortality prediction among different variants.METHODS: 6667 individuals from the Inter99 General Population Study were followed for a median of 12.7 years. Vectorcardiograms were calculated using the Kors and Inverse Dower matrices. The QRS-Ta was calculated using both mean and peak vectors of the QRS- and T-loops. Hazard ratios (HR) for abnormal QRS-Tas were calculated using a Cox's Proportional Hazard Model.RESULTS: The highest HR and largest AUC for all-cause mortality was obtained with the Kors matrix and the mean vector (HR = 2.2, 95% confidence interval: [1.38;3.43] p < 0.001, in men). There was interaction with the orientation of the QRS-T plane.CONCLUSION: For optimal prediction of all-cause mortality, the mean vectors in the QRS- and T-loops of the Kors-derived vectorcardiogram should be used. QRS-T plane orientation affects mortality prediction.

KW - All-cause mortality

KW - Dominant vector

KW - QRS-T angle

KW - Transformation matrix

KW - Vectorcardiogram

U2 - 10.1016/j.jelectrocard.2018.05.011

DO - 10.1016/j.jelectrocard.2018.05.011

M3 - Journal article

C2 - 30177310

SN - 0022-0736

VL - 51

SP - 768

EP - 775

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 5

ER -