Space-Time Dynamics of Membrane Currents Evolve to Shape Excitation, Spiking, and Inhibition in the Cortex at Small and Large Scales

Per E. Roland

doi:10.1016/j.neuron.2017.04.038

Space-Time Dynamics of Membrane Currents Evolve to Shape Excitation, Spiking, and Inhibition in the Cortex at Small and Large Scales

Per E. Roland^*

^*Corresponding author for this work

Motor Control

3 Citations (Scopus)

Abstract

In the cerebral cortex, membrane currents, i.e., action potentials and other membrane currents, express many forms of space-time dynamics. In the spontaneous asynchronous irregular state, their space-time dynamics are local non-propagating fluctuations and sparse spiking appearing at unpredictable positions. After transition to active spiking states, larger structured zones with active spiking neurons appear, propagating through the cortical network, driving it into various forms of widespread excitation, and engaging the network from microscopic scales to whole cortical areas. At each engaged cortical site, the amount of excitation in the network, after a delay, becomes matched by an equal amount of space-time fine-tuned inhibition that might be instrumental in driving the dynamics toward perception and action.

Original language	English
Journal	Neuron
Volume	94
Issue number	5
Pages (from-to)	934-942
Number of pages	9
ISSN	0896-6273
DOIs	https://doi.org/10.1016/j.neuron.2017.04.038
Publication status	Published - Jun 2017

Keywords

brain theory
cerebral cortex
dynamical brain states
manifold
network threshold
object vision
spike trains
spontaneous activity
transient network dynamics
voluntary movements

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10.1016/j.neuron.2017.04.038

http://www.cell.com/article/S0896627317303951/pdf

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title = "Space-Time Dynamics of Membrane Currents Evolve to Shape Excitation, Spiking, and Inhibition in the Cortex at Small and Large Scales",

abstract = "In the cerebral cortex, membrane currents, i.e., action potentials and other membrane currents, express many forms of space-time dynamics. In the spontaneous asynchronous irregular state, their space-time dynamics are local non-propagating fluctuations and sparse spiking appearing at unpredictable positions. After transition to active spiking states, larger structured zones with active spiking neurons appear, propagating through the cortical network, driving it into various forms of widespread excitation, and engaging the network from microscopic scales to whole cortical areas. At each engaged cortical site, the amount of excitation in the network, after a delay, becomes matched by an equal amount of space-time fine-tuned inhibition that might be instrumental in driving the dynamics toward perception and action.",

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N2 - In the cerebral cortex, membrane currents, i.e., action potentials and other membrane currents, express many forms of space-time dynamics. In the spontaneous asynchronous irregular state, their space-time dynamics are local non-propagating fluctuations and sparse spiking appearing at unpredictable positions. After transition to active spiking states, larger structured zones with active spiking neurons appear, propagating through the cortical network, driving it into various forms of widespread excitation, and engaging the network from microscopic scales to whole cortical areas. At each engaged cortical site, the amount of excitation in the network, after a delay, becomes matched by an equal amount of space-time fine-tuned inhibition that might be instrumental in driving the dynamics toward perception and action.

AB - In the cerebral cortex, membrane currents, i.e., action potentials and other membrane currents, express many forms of space-time dynamics. In the spontaneous asynchronous irregular state, their space-time dynamics are local non-propagating fluctuations and sparse spiking appearing at unpredictable positions. After transition to active spiking states, larger structured zones with active spiking neurons appear, propagating through the cortical network, driving it into various forms of widespread excitation, and engaging the network from microscopic scales to whole cortical areas. At each engaged cortical site, the amount of excitation in the network, after a delay, becomes matched by an equal amount of space-time fine-tuned inhibition that might be instrumental in driving the dynamics toward perception and action.

KW - brain theory

KW - cerebral cortex

KW - dynamical brain states

KW - manifold

KW - network threshold

KW - object vision

KW - spike trains

KW - spontaneous activity

KW - transient network dynamics

KW - voluntary movements

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DO - 10.1016/j.neuron.2017.04.038

M3 - Review

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AN - SCOPUS:85020255160

SN - 0896-6273

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SP - 934

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JO - Neuron

JF - Neuron

IS - 5

ER -

Space-Time Dynamics of Membrane Currents Evolve to Shape Excitation, Spiking, and Inhibition in the Cortex at Small and Large Scales

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Keywords

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