Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice

Anne Petersen; Peter M.H. Heegaard; Anna L. Pedersen; Jens Bo Andersen; Rikke B. Sørensen; Hanne Frøkiær; Sampo J. Lahtinen; Arthur C. Ouwehand; Morten Poulsen; Tine Rask Licht

doi:10.1186/1471-2180-9-245

Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice

Anne Petersen, Peter M.H. Heegaard, Anna L. Pedersen, Jens Bo Andersen, Rikke B. Sørensen, Hanne Frøkiær, Sampo J. Lahtinen, Arthur C. Ouwehand, Morten Poulsen, Tine Rask Licht

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Abstract

Prebiotics are non-digestible food ingredients believed to beneficially affect host health by selectively stimulating the growth of the beneficial bacteria residing in the gut. Such beneficial bacteria have been reported to protect against pathogenic infections. However, contradicting results on prevention of Salmonella infections with prebiotics have been published. The aim of the present study was to examine whether S. Typhimurium SL1344 infection in mice could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles. BALB/c mice were fed a diet containing 10% of either of the following carbohydrates: inulin, fructo-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, apple pectin, polydextrose or beta-glucan for three weeks prior to oral Salmonella challenge (107 CFU) and compared to mice fed a cornstarch-based control diet.

Original language	English
Journal	BMC Microbiology
Volume	9
Issue number	245
Pages (from-to)	245
Number of pages	11
ISSN	1471-2180
DOIs	https://doi.org/10.1186/1471-2180-9-245
Publication status	Published - 2009

Keywords

Animals
Body Weight
Cecum
Dietary Carbohydrates
Feces
Fermentation
Haptoglobins
Hydrogen-Ion Concentration
Mice
Mice, Inbred BALB C
Prebiotics
Salmonella Infections
Salmonella typhimurium
Spleen

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title = "Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice",

abstract = "Prebiotics are non-digestible food ingredients believed to beneficially affect host health by selectively stimulating the growth of the beneficial bacteria residing in the gut. Such beneficial bacteria have been reported to protect against pathogenic infections. However, contradicting results on prevention of Salmonella infections with prebiotics have been published. The aim of the present study was to examine whether S. Typhimurium SL1344 infection in mice could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles. BALB/c mice were fed a diet containing 10% of either of the following carbohydrates: inulin, fructo-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, apple pectin, polydextrose or beta-glucan for three weeks prior to oral Salmonella challenge (107 CFU) and compared to mice fed a cornstarch-based control diet.",

keywords = "Animals, Body Weight, Cecum, Dietary Carbohydrates, Feces, Fermentation, Haptoglobins, Hydrogen-Ion Concentration, Mice, Mice, Inbred BALB C, Prebiotics, Salmonella Infections, Salmonella typhimurium, Spleen",

author = "Anne Petersen and Heegaard, {Peter M.H.} and Pedersen, {Anna L.} and Andersen, {Jens Bo} and S{\o}rensen, {Rikke B.} and Hanne Fr{\o}ki{\ae}r and Lahtinen, {Sampo J.} and Ouwehand, {Arthur C.} and Morten Poulsen and Licht, {Tine Rask}",

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T1 - Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice

AU - Petersen, Anne

AU - Heegaard, Peter M.H.

AU - Pedersen, Anna L.

AU - Andersen, Jens Bo

AU - Sørensen, Rikke B.

AU - Frøkiær, Hanne

AU - Lahtinen, Sampo J.

AU - Ouwehand, Arthur C.

AU - Poulsen, Morten

AU - Licht, Tine Rask

PY - 2009

Y1 - 2009

N2 - Prebiotics are non-digestible food ingredients believed to beneficially affect host health by selectively stimulating the growth of the beneficial bacteria residing in the gut. Such beneficial bacteria have been reported to protect against pathogenic infections. However, contradicting results on prevention of Salmonella infections with prebiotics have been published. The aim of the present study was to examine whether S. Typhimurium SL1344 infection in mice could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles. BALB/c mice were fed a diet containing 10% of either of the following carbohydrates: inulin, fructo-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, apple pectin, polydextrose or beta-glucan for three weeks prior to oral Salmonella challenge (107 CFU) and compared to mice fed a cornstarch-based control diet.

AB - Prebiotics are non-digestible food ingredients believed to beneficially affect host health by selectively stimulating the growth of the beneficial bacteria residing in the gut. Such beneficial bacteria have been reported to protect against pathogenic infections. However, contradicting results on prevention of Salmonella infections with prebiotics have been published. The aim of the present study was to examine whether S. Typhimurium SL1344 infection in mice could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles. BALB/c mice were fed a diet containing 10% of either of the following carbohydrates: inulin, fructo-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, apple pectin, polydextrose or beta-glucan for three weeks prior to oral Salmonella challenge (107 CFU) and compared to mice fed a cornstarch-based control diet.

KW - Animals

KW - Body Weight

KW - Cecum

KW - Dietary Carbohydrates

KW - Feces

KW - Fermentation

KW - Haptoglobins

KW - Hydrogen-Ion Concentration

KW - Mice

KW - Mice, Inbred BALB C

KW - Prebiotics

KW - Salmonella Infections

KW - Salmonella typhimurium

KW - Spleen

U2 - 10.1186/1471-2180-9-245

DO - 10.1186/1471-2180-9-245

M3 - Journal article

C2 - 19948011

SN - 1471-2180

VL - 9

SP - 245

JO - BMC Microbiology

JF - BMC Microbiology

IS - 245

ER -

Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice

Abstract

Keywords

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