Abstract
In many areas of genetics it is of relevance to consider a population of individuals that is founded by a single individual in the past. One model for such a scenario is the conditioned reconstructed process with Bernoulli sampling that describes the evolution of a population of individuals that originates from a single individual. Several aspects of this reconstructed process are studied, in particular the Markov structure of the process. It is shown that at any given time in the past, the conditioned reconstructed process behaves as the original conditioned reconstructed process after a suitable time-dependent change of the sampling probability. Additionally, it is discussed how mutations accumulate in a sample of particles. It is shown that random sampling of particles at the present time has the effect of making the mutation rate look time-dependent. Conditions are given under which this sampling effect is negligible. A possible extension of the reconstructed process that allows for multiple founding particles is discussed.
| Original language | English |
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| Journal | Theoretical Population Biology |
| Volume | 122 |
| Pages (from-to) | 36-45 |
| Number of pages | 10 |
| ISSN | 0040-5809 |
| DOIs | |
| Publication status | Published - Jul 2018 |