Soluble products of inflammatory reactions are not induced in children with asymptomatic Plasmodium falciparum infections

TY - JOUR

T1 - Soluble products of inflammatory reactions are not induced in children with asymptomatic Plasmodium falciparum infections

AU - Jakobsen, P H

AU - McKay, V

AU - N'Jie, R

AU - Olaleye, B O

AU - D'Alessandro, U

AU - Bendtzen, K

AU - Schousboe, I

AU - Greenwood, B M

N1 - Keywords: Antibodies, Antiphospholipid; Apolipoproteins; Child; Child, Preschool; Cytokines; Glycoproteins; Humans; Inflammation; Malaria, Falciparum; Seasons; Solubility; beta 2-Glycoprotein I

PY - 1996

Y1 - 1996

N2 - A proportion of children with Plasmodium falciparum infection have a high parasitaemia without accompanying fever, indicative of different clinical thresholds of parasitaemia. Higher levels of IL-10, IL-1Ra and sIL-4R but not sIL-2R were found in children with P. falciparum malaria, compared with levels in children with asymptomatic P. falciparum infections and in healthy children. Concentrations of IL-10 and IL-1Ra were correlated with levels of parasitaemia, but the association of cytokine levels with disease was independent of the association with parasitaemia. Children may tolerate a high parasitaemia by neutralizing the parasite-derived toxins. When studying potential anti-toxic molecules we found that children with symptomatic infections had lower concentrations of a phospholipid-binding molecule, beta 2-glycoprotein I (beta 2-GPI), compared with children with asymptomatic infections or healthy children. In conclusion, cytokines were found in much higher concentrations in children with symptomatic P. falciparum malaria than in children with asymptomatic infections, whilst the former had lower concentrations of beta 2-GPI.

AB - A proportion of children with Plasmodium falciparum infection have a high parasitaemia without accompanying fever, indicative of different clinical thresholds of parasitaemia. Higher levels of IL-10, IL-1Ra and sIL-4R but not sIL-2R were found in children with P. falciparum malaria, compared with levels in children with asymptomatic P. falciparum infections and in healthy children. Concentrations of IL-10 and IL-1Ra were correlated with levels of parasitaemia, but the association of cytokine levels with disease was independent of the association with parasitaemia. Children may tolerate a high parasitaemia by neutralizing the parasite-derived toxins. When studying potential anti-toxic molecules we found that children with symptomatic infections had lower concentrations of a phospholipid-binding molecule, beta 2-glycoprotein I (beta 2-GPI), compared with children with asymptomatic infections or healthy children. In conclusion, cytokines were found in much higher concentrations in children with symptomatic P. falciparum malaria than in children with asymptomatic infections, whilst the former had lower concentrations of beta 2-GPI.

M3 - Journal article

C2 - 8697638

SN - 0964-2536

VL - 105

SP - 69

EP - 73

JO - Clinical and Experimental Immunology, Supplement

JF - Clinical and Experimental Immunology, Supplement

IS - 1

ER -