Solubilization of water-insoluble nutraceuticals in nonionic microemulsions for water-based use

Nissim Garti; Imad Zakharia; Aviram Spernath; Anan Yaghmur; Abraham Aserin; Roy E. Hoffman; Lewis Jacobs

doi:10.1007/b93976

Solubilization of water-insoluble nutraceuticals in nonionic microemulsions for water-based use

Nissim Garti^*, Imad Zakharia, Aviram Spernath, Anan Yaghmur, Abraham Aserin, Roy E. Hoffman, Lewis Jacobs

^*Corresponding author for this work

16 Citations (Scopus)

Abstract

Winsor IV water-dilutable food-grade microemulsions based on ethoxylated sorbitan esters, water, (R)-(+)-limonene, ethanol, and propylene glycol have been prepared. Tocopherols and lycopene, two active lipophilic antioxidants, have been solubilized in the water-in-oil, bicontinuous, and oil-in-water microemulsions several times more than the oil (R)-(+)-limonene dissolution capacity. Dilution of the aqueous phase and decrease of the surfactant content strongly affect the solubilization capacity and solubilization efficiency of the microemulsion. Self-diffusion coefficients of the water and the oil in the presence of the solubilizates were correlated to the solubilization capacity, and are indicative of the locus of solubilization of the lycopene in the different microstructures.

Original language	English
Journal	Progress in Colloid and Polymer Science
Volume	126
Pages (from-to)	184-189
Number of pages	6
ISSN	0340-255X
DOIs	https://doi.org/10.1007/b93976
Publication status	Published - 13 Dec 2004

Keywords

Food microemulsion
Lycopene
Self-diffusion NMR
Solubilization capacity
Tocopherols
Vitamin E

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title = "Solubilization of water-insoluble nutraceuticals in nonionic microemulsions for water-based use",

abstract = "Winsor IV water-dilutable food-grade microemulsions based on ethoxylated sorbitan esters, water, (R)-(+)-limonene, ethanol, and propylene glycol have been prepared. Tocopherols and lycopene, two active lipophilic antioxidants, have been solubilized in the water-in-oil, bicontinuous, and oil-in-water microemulsions several times more than the oil (R)-(+)-limonene dissolution capacity. Dilution of the aqueous phase and decrease of the surfactant content strongly affect the solubilization capacity and solubilization efficiency of the microemulsion. Self-diffusion coefficients of the water and the oil in the presence of the solubilizates were correlated to the solubilization capacity, and are indicative of the locus of solubilization of the lycopene in the different microstructures.",

keywords = "Food microemulsion, Lycopene, Self-diffusion NMR, Solubilization capacity, Tocopherols, Vitamin E",

author = "Nissim Garti and Imad Zakharia and Aviram Spernath and Anan Yaghmur and Abraham Aserin and Hoffman, {Roy E.} and Lewis Jacobs",

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doi = "10.1007/b93976",

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journal = "Colloid and Polymer Science",

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T1 - Solubilization of water-insoluble nutraceuticals in nonionic microemulsions for water-based use

AU - Garti, Nissim

AU - Zakharia, Imad

AU - Spernath, Aviram

AU - Yaghmur, Anan

AU - Aserin, Abraham

AU - Hoffman, Roy E.

AU - Jacobs, Lewis

PY - 2004/12/13

Y1 - 2004/12/13

N2 - Winsor IV water-dilutable food-grade microemulsions based on ethoxylated sorbitan esters, water, (R)-(+)-limonene, ethanol, and propylene glycol have been prepared. Tocopherols and lycopene, two active lipophilic antioxidants, have been solubilized in the water-in-oil, bicontinuous, and oil-in-water microemulsions several times more than the oil (R)-(+)-limonene dissolution capacity. Dilution of the aqueous phase and decrease of the surfactant content strongly affect the solubilization capacity and solubilization efficiency of the microemulsion. Self-diffusion coefficients of the water and the oil in the presence of the solubilizates were correlated to the solubilization capacity, and are indicative of the locus of solubilization of the lycopene in the different microstructures.

AB - Winsor IV water-dilutable food-grade microemulsions based on ethoxylated sorbitan esters, water, (R)-(+)-limonene, ethanol, and propylene glycol have been prepared. Tocopherols and lycopene, two active lipophilic antioxidants, have been solubilized in the water-in-oil, bicontinuous, and oil-in-water microemulsions several times more than the oil (R)-(+)-limonene dissolution capacity. Dilution of the aqueous phase and decrease of the surfactant content strongly affect the solubilization capacity and solubilization efficiency of the microemulsion. Self-diffusion coefficients of the water and the oil in the presence of the solubilizates were correlated to the solubilization capacity, and are indicative of the locus of solubilization of the lycopene in the different microstructures.

KW - Food microemulsion

KW - Lycopene

KW - Self-diffusion NMR

KW - Solubilization capacity

KW - Tocopherols

KW - Vitamin E

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DO - 10.1007/b93976

M3 - Journal article

AN - SCOPUS:9644279492

SN - 0303-402X

VL - 126

SP - 184

EP - 189

JO - Colloid and Polymer Science

JF - Colloid and Polymer Science

ER -

Solubilization of water-insoluble nutraceuticals in nonionic microemulsions for water-based use

Abstract

Keywords

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