Abstract
Solid-state interactions between trimethoprim and the esters of 4-hydroxybenzoic acid (parahydroxybenzoates or parabens) used for anti-microbial preservation are investigated. The formation of a crystalline 1/1 molecular compound between trimethoprim and methyl parahydroxybenzoate is demonstrated by differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and solid-state C-13-NMR. Interactions between trimethoprim and 4-hydroxybenzoic acid and its ethyl,propyl and butyl esters were not observed. The nature of the trimethoprim and methyl parahydroxybenzoate intermolecular bonding is discussed briefly.
| Original language | Undefined/Unknown |
|---|---|
| Journal | STP pharma sciences |
| Volume | 4 |
| Issue number | 4 |
| Pages (from-to) | 292-297 |
| Number of pages | 6 |
| Publication status | Published - 1994 |