Solid-phase microextraction/capillary gas chromatography for the profiling of confiscated ecstacy and amphetamine

TY - JOUR

T1 - Solid-phase microextraction/capillary gas chromatography for the profiling of confiscated ecstacy and amphetamine

AU - Kongshaug, K. E.

AU - Pedersen-Bjergaard, S.

AU - Rasmussen, K. E.

AU - Krogh, M.

PY - 1999/9/1

Y1 - 1999/9/1

N2 - Impurity profiling of ecstacy and amphetamine seizures was accomplished by solid-phase microextraction (SPME) combined with capillary gas chromatography (GC). Samples were dissolved in 0.1 M aqueous acetate buffer (pH 5.0) as the only manual operation and subsequently subjected to SPME-GC. Ecstacy tablets were analyzed by head-space SPME to avoid contamination of SPME fibers with insoluble tablet components, while illicit amphetamine powders were exposed to immersed SPME. A SPME fiber of polydimethylsiloxane- divinylbenzene was found to provide excellent extraction of both polar and non-polar impurities. For both illicit ecstacy and amphetamine, complex impurity profiles were obtained by SPME providing a high information content. For ecstacy, profiles (relative peak areas) were repeatable within 2.2 to 12.6% RSD (n = 6), while similar data on amphetamine varied between 2.0 and 10.9 % RSD (n = 6). No carry-over was observed although each fiber was used for 50 to 100 extractions.

AB - Impurity profiling of ecstacy and amphetamine seizures was accomplished by solid-phase microextraction (SPME) combined with capillary gas chromatography (GC). Samples were dissolved in 0.1 M aqueous acetate buffer (pH 5.0) as the only manual operation and subsequently subjected to SPME-GC. Ecstacy tablets were analyzed by head-space SPME to avoid contamination of SPME fibers with insoluble tablet components, while illicit amphetamine powders were exposed to immersed SPME. A SPME fiber of polydimethylsiloxane- divinylbenzene was found to provide excellent extraction of both polar and non-polar impurities. For both illicit ecstacy and amphetamine, complex impurity profiles were obtained by SPME providing a high information content. For ecstacy, profiles (relative peak areas) were repeatable within 2.2 to 12.6% RSD (n = 6), while similar data on amphetamine varied between 2.0 and 10.9 % RSD (n = 6). No carry-over was observed although each fiber was used for 50 to 100 extractions.

KW - Amphetamine

KW - Capillary gas chromatography

KW - Ecstacy

KW - Solid-phase microextraction

UR - http://www.scopus.com/inward/record.url?scp=0032792567&partnerID=8YFLogxK

U2 - 10.1007/BF02490660

DO - 10.1007/BF02490660

M3 - Journal article

AN - SCOPUS:0032792567

SN - 0009-5893

VL - 50

SP - 247

EP - 252

JO - Chromatographia

JF - Chromatographia

IS - 3-4

ER -