Socioeconomic position and mortality among patients with prostate cancer: influence of mediating factors

Signe Benzon Larsen; Klaus Brasso; Jane Christensen; Christoffer Johansen; Anne Tjønneland; Søren Friis; Peter Iversen; Susanne Oksbjerg Dalton

doi:10.1080/0284186x.2016.1260771

Socioeconomic position and mortality among patients with prostate cancer: influence of mediating factors

Signe Benzon Larsen, Klaus Brasso, Jane Christensen, Christoffer Johansen, Anne Tjønneland, Søren Friis, Peter Iversen, Susanne Oksbjerg Dalton

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

INTRODUCTION: Men with low socioeconomic position experience higher mortality after a prostate cancer diagnosis compared to men with a higher socioeconomic position, however, the specific mediators of this association are unclear. We therefore evaluated the influence of potential mediators on the association between socioeconomic position, and prostate cancer-specific and all-cause death in prostate cancer patients.

MATERIALS AND METHODS: We conducted a cohort study of prostate cancer patients in the Danish Diet, Cancer and Health study. All patients completed questionnaires and anthropometric measurements at enrollment. Information on educational level, income, comorbidity and vital status was obtained by linkage to Danish nationwide registries. Clinical data and anthropometric measures were collected from medical records at diagnosis. Cox proportional hazard models were used to compute hazard ratios (HR) for all-cause and prostate cancer-specific death according to socioeconomic position and potential mediators.

RESULTS: We included 953 prostate cancer patients identified among 27 179 male participants in the Diet, Cancer and Health study who were followed for a median of 6.5 years (interquartile range 6.4-11.2 years). Patients with low socioeconomic position were more often overweight or obese at baseline. Low socioeconomic position was associated with increased prostate cancer-specific and all-cause death. The increased mortality could largely be explained by tumor aggressiveness, comorbidity, treatment and metabolic indicators, except for patients in the lowest income group.

DISCUSSION: Our study confirmed the a priori assumption that socioeconomic position is associated with increased mortality after prostate cancer. The increased mortality could largely be explained by lifestyle and clinical parameters.

Original language	English
Journal	Acta Oncologica
Volume	56
Issue number	4
Pages (from-to)	563-568
Number of pages	6
ISSN	0284-186X
DOIs	https://doi.org/10.1080/0284186x.2016.1260771
Publication status	Published - 3 Apr 2017

Keywords

Aged
Cohort Studies
Comorbidity
Denmark
Humans
Male
Middle Aged
Proportional Hazards Models
Prostatic Neoplasms
Socioeconomic Factors
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/0284186x.2016.1260771

0284186X.2016.1260771?needAccess=trueFinal published version, 923 KB

https://www.tandfonline.com/doi/pdf/10.1080/0284186X.2016.1260771?needAccess=true

Cite this

@article{3da15e2c7a1145cb8a965399b4050c5b,

title = "Socioeconomic position and mortality among patients with prostate cancer: influence of mediating factors",

abstract = "INTRODUCTION: Men with low socioeconomic position experience higher mortality after a prostate cancer diagnosis compared to men with a higher socioeconomic position, however, the specific mediators of this association are unclear. We therefore evaluated the influence of potential mediators on the association between socioeconomic position, and prostate cancer-specific and all-cause death in prostate cancer patients.MATERIALS AND METHODS: We conducted a cohort study of prostate cancer patients in the Danish Diet, Cancer and Health study. All patients completed questionnaires and anthropometric measurements at enrollment. Information on educational level, income, comorbidity and vital status was obtained by linkage to Danish nationwide registries. Clinical data and anthropometric measures were collected from medical records at diagnosis. Cox proportional hazard models were used to compute hazard ratios (HR) for all-cause and prostate cancer-specific death according to socioeconomic position and potential mediators.RESULTS: We included 953 prostate cancer patients identified among 27 179 male participants in the Diet, Cancer and Health study who were followed for a median of 6.5 years (interquartile range 6.4-11.2 years). Patients with low socioeconomic position were more often overweight or obese at baseline. Low socioeconomic position was associated with increased prostate cancer-specific and all-cause death. The increased mortality could largely be explained by tumor aggressiveness, comorbidity, treatment and metabolic indicators, except for patients in the lowest income group.DISCUSSION: Our study confirmed the a priori assumption that socioeconomic position is associated with increased mortality after prostate cancer. The increased mortality could largely be explained by lifestyle and clinical parameters.",

keywords = "Aged, Cohort Studies, Comorbidity, Denmark, Humans, Male, Middle Aged, Proportional Hazards Models, Prostatic Neoplasms, Socioeconomic Factors, Journal Article",

author = "Larsen, {Signe Benzon} and Klaus Brasso and Jane Christensen and Christoffer Johansen and Anne Tj{\o}nneland and S{\o}ren Friis and Peter Iversen and Dalton, {Susanne Oksbjerg}",

year = "2017",

month = apr,

day = "3",

doi = "10.1080/0284186x.2016.1260771",

language = "English",

volume = "56",

pages = "563--568",

journal = "Acta Oncologica, Supplement",

issn = "1100-1704",

publisher = "Taylor & Francis",

number = "4",

}

TY - JOUR

T1 - Socioeconomic position and mortality among patients with prostate cancer

T2 - influence of mediating factors

AU - Larsen, Signe Benzon

AU - Brasso, Klaus

AU - Christensen, Jane

AU - Johansen, Christoffer

AU - Tjønneland, Anne

AU - Friis, Søren

AU - Iversen, Peter

AU - Dalton, Susanne Oksbjerg

PY - 2017/4/3

Y1 - 2017/4/3

N2 - INTRODUCTION: Men with low socioeconomic position experience higher mortality after a prostate cancer diagnosis compared to men with a higher socioeconomic position, however, the specific mediators of this association are unclear. We therefore evaluated the influence of potential mediators on the association between socioeconomic position, and prostate cancer-specific and all-cause death in prostate cancer patients.MATERIALS AND METHODS: We conducted a cohort study of prostate cancer patients in the Danish Diet, Cancer and Health study. All patients completed questionnaires and anthropometric measurements at enrollment. Information on educational level, income, comorbidity and vital status was obtained by linkage to Danish nationwide registries. Clinical data and anthropometric measures were collected from medical records at diagnosis. Cox proportional hazard models were used to compute hazard ratios (HR) for all-cause and prostate cancer-specific death according to socioeconomic position and potential mediators.RESULTS: We included 953 prostate cancer patients identified among 27 179 male participants in the Diet, Cancer and Health study who were followed for a median of 6.5 years (interquartile range 6.4-11.2 years). Patients with low socioeconomic position were more often overweight or obese at baseline. Low socioeconomic position was associated with increased prostate cancer-specific and all-cause death. The increased mortality could largely be explained by tumor aggressiveness, comorbidity, treatment and metabolic indicators, except for patients in the lowest income group.DISCUSSION: Our study confirmed the a priori assumption that socioeconomic position is associated with increased mortality after prostate cancer. The increased mortality could largely be explained by lifestyle and clinical parameters.

AB - INTRODUCTION: Men with low socioeconomic position experience higher mortality after a prostate cancer diagnosis compared to men with a higher socioeconomic position, however, the specific mediators of this association are unclear. We therefore evaluated the influence of potential mediators on the association between socioeconomic position, and prostate cancer-specific and all-cause death in prostate cancer patients.MATERIALS AND METHODS: We conducted a cohort study of prostate cancer patients in the Danish Diet, Cancer and Health study. All patients completed questionnaires and anthropometric measurements at enrollment. Information on educational level, income, comorbidity and vital status was obtained by linkage to Danish nationwide registries. Clinical data and anthropometric measures were collected from medical records at diagnosis. Cox proportional hazard models were used to compute hazard ratios (HR) for all-cause and prostate cancer-specific death according to socioeconomic position and potential mediators.RESULTS: We included 953 prostate cancer patients identified among 27 179 male participants in the Diet, Cancer and Health study who were followed for a median of 6.5 years (interquartile range 6.4-11.2 years). Patients with low socioeconomic position were more often overweight or obese at baseline. Low socioeconomic position was associated with increased prostate cancer-specific and all-cause death. The increased mortality could largely be explained by tumor aggressiveness, comorbidity, treatment and metabolic indicators, except for patients in the lowest income group.DISCUSSION: Our study confirmed the a priori assumption that socioeconomic position is associated with increased mortality after prostate cancer. The increased mortality could largely be explained by lifestyle and clinical parameters.

KW - Aged

KW - Cohort Studies

KW - Comorbidity

KW - Denmark

KW - Humans

KW - Male

KW - Middle Aged

KW - Proportional Hazards Models

KW - Prostatic Neoplasms

KW - Socioeconomic Factors

KW - Journal Article

U2 - 10.1080/0284186x.2016.1260771

DO - 10.1080/0284186x.2016.1260771

M3 - Journal article

C2 - 27911129

SN - 1100-1704

VL - 56

SP - 563

EP - 568

JO - Acta Oncologica, Supplement

JF - Acta Oncologica, Supplement

IS - 4

ER -

Socioeconomic position and mortality among patients with prostate cancer: influence of mediating factors

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this