Socio-economic differences in cardiometabolic risk markers are mediated by diet and body fatness in 8- to 11-year-old Danish children: A cross-sectional study

Hanne Hauger; Margit Velsing Groth; Christian Ritz; Anja Biltoft-Jensen; Rikke Andersen; Stine-Mathilde Dalskov; Mads Fiil Hjorth; Anders Mikael Sjödin; Arne Astrup; Kim F. Michaelsen; Camilla Trab Damsgaard

doi:10.1017/s1368980015003766

Socio-economic differences in cardiometabolic risk markers are mediated by diet and body fatness in 8- to 11-year-old Danish children: A cross-sectional study

Hanne Hauger, Margit Velsing Groth, Christian Ritz, Anja Biltoft-Jensen, Rikke Andersen, Stine-Mathilde Dalskov, Mads Fiil Hjorth, Anders Mikael Sjödin, Arne Astrup, Kim F. Michaelsen, Camilla Trab Damsgaard

2 Citations (Scopus)

Abstract

Objective To explore whether socio-economic differences exist in cardiometabolic risk markers in children and whether lifestyle-related factors potentially mediate these differences. Design Cross-sectional study including measurements of fasting blood lipids, glucose, homeostasis model assessment of insulin resistance (HOMA-IR), blood pressure and heart rate. Potential mediators examined were fat mass index (FMI); intakes of fruit, vegetables, dietary fibre and added sugar; whole-blood n-3 long-chain PUFA (LCPUFA) as a biomarker of fish intake; and physical activity and sedentary time. Setting Nine primary schools in Denmark. Subjects Children aged 8-11 years (n 715). Results Children of parents with the shortest compared with longest education had higher TAG by 0·12 (95 % CI 0·04, 0·21) mmol/l and HOMA-IR by 0·36 (0·10, 0·62), whereas children of parents with a vocational education had higher total cholesterol by 0·14 (0·02, 0·27) mmol/l and LDL cholesterol by 0·14 (0·03, 0·25) mmol/l compared with children of parents with the longest education; all P<0·05. FMI explained 25 % of the difference in TAG, 64 % of the difference in HOMA-IR and 21-29 % of the differences in cholesterols. FMI and whole-blood n-3 LCPUFA combined explained 42 % of the difference in TAG, whereas FMI, whole-blood n-3 LCPUFA and dietary fibre explained 89 % of the difference in HOMA-IR. Conclusions Socio-economic differences were present in blood lipids and insulin resistance among 8- to 11-year-olds and were mediated by body fatness, whole-blood n-3 LCPUFA and dietary fibre. These lifestyle factors may be targets in public initiatives to reduce socio-economic differences. Confirmation in longitudinal studies and trials is warranted.

Original language	English
Journal	Public Health Nutrition
Volume	19
Issue number	12
Pages (from-to)	2229-2239
Number of pages	11
ISSN	1368-9800
DOIs	https://doi.org/10.1017/s1368980015003766
Publication status	Published - 1 Aug 2016

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div-class-title-socio-economic-differences-in-cardiometabolic-risk-markers-are-mediated-by-diet-and-body-fatness-in-8-to-11-year-old-danish-children-a-cross-sectional-study-div.pdfFinal published version, 195 KB

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Hauger, H., Groth, M. V., Ritz, C., Biltoft-Jensen, A., Andersen, R., Dalskov, S-M., Hjorth, M. F., Sjödin, A. M., Astrup, A., Michaelsen, K. F., & Damsgaard, C. T. (2016). Socio-economic differences in cardiometabolic risk markers are mediated by diet and body fatness in 8- to 11-year-old Danish children: A cross-sectional study. Public Health Nutrition, 19(12), 2229-2239. https://doi.org/10.1017/s1368980015003766

Socio-economic differences in cardiometabolic risk markers are mediated by diet and body fatness in 8- to 11-year-old Danish children : A cross-sectional study. / Hauger, Hanne; Groth, Margit Velsing; Ritz, Christian et al.

In: Public Health Nutrition, Vol. 19, No. 12, 01.08.2016, p. 2229-2239.

Research output: Contribution to journal › Journal article › Research › peer-review

Hauger, H, Groth, MV, Ritz, C, Biltoft-Jensen, A, Andersen, R, Dalskov, S-M, Hjorth, MF , Sjödin, AM, Astrup, A, Michaelsen, KF & Damsgaard, CT 2016, 'Socio-economic differences in cardiometabolic risk markers are mediated by diet and body fatness in 8- to 11-year-old Danish children: A cross-sectional study', Public Health Nutrition, vol. 19, no. 12, pp. 2229-2239. https://doi.org/10.1017/s1368980015003766

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title = "Socio-economic differences in cardiometabolic risk markers are mediated by diet and body fatness in 8- to 11-year-old Danish children: A cross-sectional study",

abstract = "Objective To explore whether socio-economic differences exist in cardiometabolic risk markers in children and whether lifestyle-related factors potentially mediate these differences. Design Cross-sectional study including measurements of fasting blood lipids, glucose, homeostasis model assessment of insulin resistance (HOMA-IR), blood pressure and heart rate. Potential mediators examined were fat mass index (FMI); intakes of fruit, vegetables, dietary fibre and added sugar; whole-blood n-3 long-chain PUFA (LCPUFA) as a biomarker of fish intake; and physical activity and sedentary time. Setting Nine primary schools in Denmark. Subjects Children aged 8-11 years (n 715). Results Children of parents with the shortest compared with longest education had higher TAG by 0·12 (95 % CI 0·04, 0·21) mmol/l and HOMA-IR by 0·36 (0·10, 0·62), whereas children of parents with a vocational education had higher total cholesterol by 0·14 (0·02, 0·27) mmol/l and LDL cholesterol by 0·14 (0·03, 0·25) mmol/l compared with children of parents with the longest education; all P<0·05. FMI explained 25 % of the difference in TAG, 64 % of the difference in HOMA-IR and 21-29 % of the differences in cholesterols. FMI and whole-blood n-3 LCPUFA combined explained 42 % of the difference in TAG, whereas FMI, whole-blood n-3 LCPUFA and dietary fibre explained 89 % of the difference in HOMA-IR. Conclusions Socio-economic differences were present in blood lipids and insulin resistance among 8- to 11-year-olds and were mediated by body fatness, whole-blood n-3 LCPUFA and dietary fibre. These lifestyle factors may be targets in public initiatives to reduce socio-economic differences. Confirmation in longitudinal studies and trials is warranted.",

author = "Hanne Hauger and Groth, {Margit Velsing} and Christian Ritz and Anja Biltoft-Jensen and Rikke Andersen and Stine-Mathilde Dalskov and Hjorth, {Mads Fiil} and Sj{\"o}din, {Anders Mikael} and Arne Astrup and Michaelsen, {Kim F.} and Damsgaard, {Camilla Trab}",

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doi = "10.1017/s1368980015003766",

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TY - JOUR

T1 - Socio-economic differences in cardiometabolic risk markers are mediated by diet and body fatness in 8- to 11-year-old Danish children

T2 - A cross-sectional study

AU - Hauger, Hanne

AU - Groth, Margit Velsing

AU - Ritz, Christian

AU - Biltoft-Jensen, Anja

AU - Andersen, Rikke

AU - Dalskov, Stine-Mathilde

AU - Hjorth, Mads Fiil

AU - Sjödin, Anders Mikael

AU - Astrup, Arne

AU - Michaelsen, Kim F.

AU - Damsgaard, Camilla Trab

N1 - CURIS 2016 NEXS 076

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objective To explore whether socio-economic differences exist in cardiometabolic risk markers in children and whether lifestyle-related factors potentially mediate these differences. Design Cross-sectional study including measurements of fasting blood lipids, glucose, homeostasis model assessment of insulin resistance (HOMA-IR), blood pressure and heart rate. Potential mediators examined were fat mass index (FMI); intakes of fruit, vegetables, dietary fibre and added sugar; whole-blood n-3 long-chain PUFA (LCPUFA) as a biomarker of fish intake; and physical activity and sedentary time. Setting Nine primary schools in Denmark. Subjects Children aged 8-11 years (n 715). Results Children of parents with the shortest compared with longest education had higher TAG by 0·12 (95 % CI 0·04, 0·21) mmol/l and HOMA-IR by 0·36 (0·10, 0·62), whereas children of parents with a vocational education had higher total cholesterol by 0·14 (0·02, 0·27) mmol/l and LDL cholesterol by 0·14 (0·03, 0·25) mmol/l compared with children of parents with the longest education; all P<0·05. FMI explained 25 % of the difference in TAG, 64 % of the difference in HOMA-IR and 21-29 % of the differences in cholesterols. FMI and whole-blood n-3 LCPUFA combined explained 42 % of the difference in TAG, whereas FMI, whole-blood n-3 LCPUFA and dietary fibre explained 89 % of the difference in HOMA-IR. Conclusions Socio-economic differences were present in blood lipids and insulin resistance among 8- to 11-year-olds and were mediated by body fatness, whole-blood n-3 LCPUFA and dietary fibre. These lifestyle factors may be targets in public initiatives to reduce socio-economic differences. Confirmation in longitudinal studies and trials is warranted.

AB - Objective To explore whether socio-economic differences exist in cardiometabolic risk markers in children and whether lifestyle-related factors potentially mediate these differences. Design Cross-sectional study including measurements of fasting blood lipids, glucose, homeostasis model assessment of insulin resistance (HOMA-IR), blood pressure and heart rate. Potential mediators examined were fat mass index (FMI); intakes of fruit, vegetables, dietary fibre and added sugar; whole-blood n-3 long-chain PUFA (LCPUFA) as a biomarker of fish intake; and physical activity and sedentary time. Setting Nine primary schools in Denmark. Subjects Children aged 8-11 years (n 715). Results Children of parents with the shortest compared with longest education had higher TAG by 0·12 (95 % CI 0·04, 0·21) mmol/l and HOMA-IR by 0·36 (0·10, 0·62), whereas children of parents with a vocational education had higher total cholesterol by 0·14 (0·02, 0·27) mmol/l and LDL cholesterol by 0·14 (0·03, 0·25) mmol/l compared with children of parents with the longest education; all P<0·05. FMI explained 25 % of the difference in TAG, 64 % of the difference in HOMA-IR and 21-29 % of the differences in cholesterols. FMI and whole-blood n-3 LCPUFA combined explained 42 % of the difference in TAG, whereas FMI, whole-blood n-3 LCPUFA and dietary fibre explained 89 % of the difference in HOMA-IR. Conclusions Socio-economic differences were present in blood lipids and insulin resistance among 8- to 11-year-olds and were mediated by body fatness, whole-blood n-3 LCPUFA and dietary fibre. These lifestyle factors may be targets in public initiatives to reduce socio-economic differences. Confirmation in longitudinal studies and trials is warranted.

U2 - 10.1017/s1368980015003766

DO - 10.1017/s1368980015003766

M3 - Journal article

C2 - 26926594

SN - 1368-9800

VL - 19

SP - 2229

EP - 2239

JO - Public Health Nutrition

JF - Public Health Nutrition

IS - 12

ER -

Socio-economic differences in cardiometabolic risk markers are mediated by diet and body fatness in 8- to 11-year-old Danish children: A cross-sectional study

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