Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study

Camilla Jerlang Christiani; Jens R M Jepsen; Anne Thorup; Nicoline Hemager; Ditte Ellersgaard; Katrine S Spang; Birgitte K Burton; Maja Gregersen; Anne Søndergaard; Aja N Greve; Ditte L Gantriis; Gry Poulsen; Md Jamal Uddin; Larry J Seidman; Ole Mors; Kerstin J Plessen; Merete Nordentoft

doi:10.1093/schbul/sbz001

Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study

Camilla Jerlang Christiani, Jens R M Jepsen, Anne Thorup, Nicoline Hemager, Ditte Ellersgaard, Katrine S Spang, Birgitte K Burton, Maja Gregersen, Anne Søndergaard, Aja N Greve, Ditte L Gantriis, Gry Poulsen, Md Jamal Uddin, Larry J Seidman, Ole Mors, Kerstin J Plessen, Merete Nordentoft

11 Citations (Scopus)

Abstract

Objective: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). Methods: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior. Results: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P =. 006; pragmatic: d = -0.51, P <. 001), social responsiveness (d = -0.54, P <. 001), and adaptive social functioning (d = -0.47, P <. 001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P =. 007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction. Conclusion: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

Original language	English
Journal	Schizophrenia Bulletin
Volume	45
Issue number	6
Pages (from-to)	1218-1230
Number of pages	13
ISSN	0586-7614
DOIs	https://doi.org/10.1093/schbul/sbz001
Publication status	Published - 24 Oct 2019

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Christiani, C. J., Jepsen, J. R. M., Thorup, A., Hemager, N., Ellersgaard, D., Spang, K. S., Burton, B. K., Gregersen, M., Søndergaard, A., Greve, A. N., Gantriis, D. L., Poulsen, G., Uddin, M. J., Seidman, L. J., Mors, O., Plessen, K. J., & Nordentoft, M. (2019). Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study. Schizophrenia Bulletin, 45(6), 1218-1230. https://doi.org/10.1093/schbul/sbz001

Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study. / Christiani, Camilla Jerlang; Jepsen, Jens R M; Thorup, Anne et al.
In: Schizophrenia Bulletin, Vol. 45, No. 6, 24.10.2019, p. 1218-1230.

Research output: Contribution to journal › Journal article › Research › peer-review

Christiani, CJ, Jepsen, JRM, Thorup, A, Hemager, N, Ellersgaard, D, Spang, KS, Burton, BK, Gregersen, M, Søndergaard, A, Greve, AN, Gantriis, DL, Poulsen, G, Uddin, MJ, Seidman, LJ, Mors, O, Plessen, KJ & Nordentoft, M 2019, 'Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study', Schizophrenia Bulletin, vol. 45, no. 6, pp. 1218-1230. https://doi.org/10.1093/schbul/sbz001

Christiani CJ, Jepsen JRM, Thorup A, Hemager N, Ellersgaard D, Spang KS et al. Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study. Schizophrenia Bulletin. 2019 Oct 24;45(6):1218-1230. doi: 10.1093/schbul/sbz001

@article{d8204e4bc24d4fbc86ad5613f027f9e3,

title = "Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study",

abstract = "Objective: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). Methods: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior. Results: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P =. 006; pragmatic: d = -0.51, P <. 001), social responsiveness (d = -0.54, P <. 001), and adaptive social functioning (d = -0.47, P <. 001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P =. 007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction. Conclusion: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.",

author = "Christiani, {Camilla Jerlang} and Jepsen, {Jens R M} and Anne Thorup and Nicoline Hemager and Ditte Ellersgaard and Spang, {Katrine S} and Burton, {Birgitte K} and Maja Gregersen and Anne S{\o}ndergaard and Greve, {Aja N} and Gantriis, {Ditte L} and Gry Poulsen and Uddin, {Md Jamal} and Seidman, {Larry J} and Ole Mors and Plessen, {Kerstin J} and Merete Nordentoft",

note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.All rights reserved. For permissions, please email: [email protected].",

year = "2019",

month = oct,

day = "24",

doi = "10.1093/schbul/sbz001",

language = "English",

volume = "45",

pages = "1218--1230",

journal = "Schizophrenia Bulletin",

issn = "0586-7614",

publisher = "Oxford University Press",

number = "6",

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TY - JOUR

T1 - Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder

T2 - The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study

AU - Christiani, Camilla Jerlang

AU - Jepsen, Jens R M

AU - Thorup, Anne

AU - Hemager, Nicoline

AU - Ellersgaard, Ditte

AU - Spang, Katrine S

AU - Burton, Birgitte K

AU - Gregersen, Maja

AU - Søndergaard, Anne

AU - Greve, Aja N

AU - Gantriis, Ditte L

AU - Poulsen, Gry

AU - Uddin, Md Jamal

AU - Seidman, Larry J

AU - Mors, Ole

AU - Plessen, Kerstin J

AU - Nordentoft, Merete

PY - 2019/10/24

Y1 - 2019/10/24

N2 - Objective: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). Methods: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior. Results: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P =. 006; pragmatic: d = -0.51, P <. 001), social responsiveness (d = -0.54, P <. 001), and adaptive social functioning (d = -0.47, P <. 001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P =. 007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction. Conclusion: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

AB - Objective: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). Methods: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior. Results: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P =. 006; pragmatic: d = -0.51, P <. 001), social responsiveness (d = -0.54, P <. 001), and adaptive social functioning (d = -0.47, P <. 001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P =. 007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction. Conclusion: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

U2 - 10.1093/schbul/sbz001

DO - 10.1093/schbul/sbz001

M3 - Journal article

C2 - 30852621

SN - 0586-7614

VL - 45

SP - 1218

EP - 1230

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

IS - 6

ER -