SNPs in PPARG associate with type 2 diabetes and interact with physical activity

Tuomas Oskari Kilpeläinen; Timo A Lakka; David E Laaksonen; Jaana Lindström; Johan G Eriksson; Timo T Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Virpi Lindi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso

doi:10.1249/mss.0b013e318159d1cd

SNPs in PPARG associate with type 2 diabetes and interact with physical activity

Tuomas Oskari Kilpeläinen, Timo A Lakka, David E Laaksonen, Jaana Lindström, Johan G Eriksson, Timo T Valle, Helena Hämäläinen, Pirjo Ilanne-Parikka, Sirkka Keinänen-Kiukaanniemi, Virpi Lindi, Jaakko Tuomilehto, Matti Uusitupa, Markku Laakso

34 Citations (Scopus)

Abstract

To study the associations of seven single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes (T2D), and the interactions of the SNPs with physical activity (PA).

Original language	English
Journal	Medicine and Science in Sports and Exercise
Volume	40
Issue number	1
Pages (from-to)	25-33
Number of pages	9
ISSN	0195-9131
DOIs	https://doi.org/10.1249/mss.0b013e318159d1cd
Publication status	Published - Jan 2008

Keywords

Alleles
Diabetes Mellitus, Type 2
Exercise
Female
Genotype
Glucose Intolerance
Glucose Tolerance Test
Humans
Leisure Activities
Life Style
Male
Middle Aged
Motor Activity
PPAR gamma
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Oskari Kilpeläinen, T., Lakka, T. A., Laaksonen, D. E., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Lindi, V., Tuomilehto, J., Uusitupa, M., & Laakso, M. (2008). SNPs in PPARG associate with type 2 diabetes and interact with physical activity. Medicine and Science in Sports and Exercise, 40(1), 25-33. https://doi.org/10.1249/mss.0b013e318159d1cd

Oskari Kilpeläinen, T, Lakka, TA, Laaksonen, DE, Lindström, J, Eriksson, JG, Valle, TT, Hämäläinen, H, Ilanne-Parikka, P, Keinänen-Kiukaanniemi, S, Lindi, V, Tuomilehto, J, Uusitupa, M & Laakso, M 2008, 'SNPs in PPARG associate with type 2 diabetes and interact with physical activity', Medicine and Science in Sports and Exercise, vol. 40, no. 1, pp. 25-33. https://doi.org/10.1249/mss.0b013e318159d1cd

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abstract = "To study the associations of seven single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes (T2D), and the interactions of the SNPs with physical activity (PA).",

keywords = "Alleles, Diabetes Mellitus, Type 2, Exercise, Female, Genotype, Glucose Intolerance, Glucose Tolerance Test, Humans, Leisure Activities, Life Style, Male, Middle Aged, Motor Activity, PPAR gamma, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Risk Factors",

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T1 - SNPs in PPARG associate with type 2 diabetes and interact with physical activity

AU - Oskari Kilpeläinen, Tuomas

AU - Lakka, Timo A

AU - Laaksonen, David E

AU - Lindström, Jaana

AU - Eriksson, Johan G

AU - Valle, Timo T

AU - Hämäläinen, Helena

AU - Ilanne-Parikka, Pirjo

AU - Keinänen-Kiukaanniemi, Sirkka

AU - Lindi, Virpi

AU - Tuomilehto, Jaakko

AU - Uusitupa, Matti

AU - Laakso, Markku

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N2 - To study the associations of seven single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes (T2D), and the interactions of the SNPs with physical activity (PA).

AB - To study the associations of seven single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes (T2D), and the interactions of the SNPs with physical activity (PA).

KW - Alleles

KW - Diabetes Mellitus, Type 2

KW - Exercise

KW - Female

KW - Genotype

KW - Glucose Intolerance

KW - Glucose Tolerance Test

KW - Humans

KW - Leisure Activities

KW - Life Style

KW - Male

KW - Middle Aged

KW - Motor Activity

KW - PPAR gamma

KW - Polymorphism, Genetic

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

U2 - 10.1249/mss.0b013e318159d1cd

DO - 10.1249/mss.0b013e318159d1cd

M3 - Journal article

C2 - 18091023

SN - 0195-9131

VL - 40

SP - 25

EP - 33

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

IS - 1

ER -

SNPs in PPARG associate with type 2 diabetes and interact with physical activity

Abstract

Keywords

UN SDGs

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