Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database

A Naranjo; S Toloza; I Guimaraes da Silveira; J Lazovskis; M L Hetland; H Hamoud; T Peets; H Mäkinen; L Gossec; G Herborn; F N Skopouli; B Rojkovich; A Aggarwal; P Minnock; M Cazzato; H Yamanaka; O Oyoo; S Rexhepi; D Andersone; A Baranauskaite; N Hajjaj-Hassouni; J W G Jacobs; G Haugeberg; S Sierakowski; R Ionescu; D Karateew; A Dimic; D Henrohn; F Gogus; H Badsha; E Choy; Ingrid-Maria Bergman; T Sokka

Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database

A Naranjo, S Toloza, I Guimaraes da Silveira, J Lazovskis, M L Hetland, H Hamoud, T Peets, H Mäkinen, L Gossec, G Herborn, F N Skopouli, B Rojkovich, A Aggarwal, P Minnock, M Cazzato, H Yamanaka, O Oyoo, S Rexhepi, D Andersone, A BaranauskaiteN Hajjaj-Hassouni, J W G Jacobs, G Haugeberg, S Sierakowski, R Ionescu, D Karateew, A Dimic, D Henrohn, F Gogus, H Badsha, E Choy, Ingrid-Maria Bergman, T Sokka

Department of Clinical Medicine

24 Citations (Scopus)

Abstract

Objectives To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1.17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41 ;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).

Original language	English
Journal	Clinical and Experimental Rheumatology
Volume	28
Issue number	6
Pages (from-to)	820-7
Number of pages	8
ISSN	0392-856X
Publication status	Published - 2010

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Naranjo, A., Toloza, S., Guimaraes da Silveira, I., Lazovskis, J., Hetland, M. L., Hamoud, H., Peets, T., Mäkinen, H., Gossec, L., Herborn, G., Skopouli, F. N., Rojkovich, B., Aggarwal, A., Minnock, P., Cazzato, M., Yamanaka, H., Oyoo, O., Rexhepi, S., Andersone, D., ... Sokka, T. (2010). Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database. Clinical and Experimental Rheumatology, 28(6), 820-7.

Naranjo, A, Toloza, S, Guimaraes da Silveira, I, Lazovskis, J, Hetland, ML, Hamoud, H, Peets, T, Mäkinen, H, Gossec, L, Herborn, G, Skopouli, FN, Rojkovich, B, Aggarwal, A, Minnock, P, Cazzato, M, Yamanaka, H, Oyoo, O, Rexhepi, S, Andersone, D, Baranauskaite, A, Hajjaj-Hassouni, N, Jacobs, JWG, Haugeberg, G, Sierakowski, S, Ionescu, R, Karateew, D, Dimic, A, Henrohn, D, Gogus, F, Badsha, H, Choy, E, Bergman, I-M & Sokka, T 2010, 'Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database', Clinical and Experimental Rheumatology, vol. 28, no. 6, pp. 820-7.

@article{7f386b4d4f834f89b004a75268505276,

title = "Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database",

abstract = "Objectives To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as {"}never smoked{"}, {"}currently smoking{"} and {"}former smokers{"}. Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307patients with smoking data available, status as {"}never smoked,{"} {"}current smoker{"} and {"}former smoker{"} were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1.17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41 ;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).",

author = "A Naranjo and S Toloza and {Guimaraes da Silveira}, I and J Lazovskis and Hetland, {M L} and H Hamoud and T Peets and H M{\"a}kinen and L Gossec and G Herborn and Skopouli, {F N} and B Rojkovich and A Aggarwal and P Minnock and M Cazzato and H Yamanaka and O Oyoo and S Rexhepi and D Andersone and A Baranauskaite and N Hajjaj-Hassouni and Jacobs, {J W G} and G Haugeberg and S Sierakowski and R Ionescu and D Karateew and A Dimic and D Henrohn and F Gogus and H Badsha and E Choy and Ingrid-Maria Bergman and T Sokka",

year = "2010",

language = "English",

volume = "28",

pages = "820--7",

journal = "Clinical and Experimental Rheumatology",

issn = "0392-856X",

publisher = "Pacini Editore SpA",

number = "6",

}

TY - JOUR

T1 - Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database

AU - Naranjo, A

AU - Toloza, S

AU - Guimaraes da Silveira, I

AU - Lazovskis, J

AU - Hetland, M L

AU - Hamoud, H

AU - Peets, T

AU - Mäkinen, H

AU - Gossec, L

AU - Herborn, G

AU - Skopouli, F N

AU - Rojkovich, B

AU - Aggarwal, A

AU - Minnock, P

AU - Cazzato, M

AU - Yamanaka, H

AU - Oyoo, O

AU - Rexhepi, S

AU - Andersone, D

AU - Baranauskaite, A

AU - Hajjaj-Hassouni, N

AU - Jacobs, J W G

AU - Haugeberg, G

AU - Sierakowski, S

AU - Ionescu, R

AU - Karateew, D

AU - Dimic, A

AU - Henrohn, D

AU - Gogus, F

AU - Badsha, H

AU - Choy, E

AU - Bergman, Ingrid-Maria

AU - Sokka, T

PY - 2010

Y1 - 2010

N2 - Objectives To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1.17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41 ;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).

AB - Objectives To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. Methods The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, pain, and patient global estimate, as well as DAS28, rheumatoid factor (RF), nodules, erosions and number of DMARDs were recorded. Smoking status was assessed by self-report as "never smoked", "currently smoking" and "former smokers". Patient groups with different smoking status were compared for demographic and RA measures. Results Among the 7,307patients with smoking data available, status as "never smoked," "current smoker" and "former smoker" were reported by 65%, 15% and 20%. Ever smokers were more likely to be RF-positive (OR 1.32;1.17-1.48, p<0.001). Rheumatoid nodules were more frequent in ever smokers (OR 1.41 ;1.24-1.59, p<0.001). The percentage of patients with erosive arthritis and extra-articular disease was similar in all smoking categories. Mean DAS28 was 4.4 (SD 1.6) in non-smokers vs. 4.0 (SD 1.6) in those who had ever smoked. However, when adjusted by age, sex, disease duration, and country gross domestic product, only ESR remained significantly different among Core Data Set measures (mean 31.7mm in non-smokers vs. 26.8mm in ever smoked category). Conclusion RA patients who had ever smoked were more likely to have RF and nodules, but values for other clinical status measures were similar in all smoking categories (never smoked, current smokers and former smokers).

M3 - Journal article

SN - 0392-856X

VL - 28

SP - 820

EP - 827

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

IS - 6

ER -

Smokers and non smokers with rheumatoid arthritis have similar clinical status: data from the multinational QUEST-RA database

Abstract

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