Small leucine-rich proteoglycans in the aging skeleton

M F Young; Y Bi; L Ameye; T Xu; S Wadhwa; Anne-Marie Heegaard; T Kilts; X D Chen

Small leucine-rich proteoglycans in the aging skeleton

M F Young, Y Bi, L Ameye, T Xu, S Wadhwa, Anne-Marie Heegaard, T Kilts, X D Chen

24 Citations (Scopus)

Abstract

Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.

Original language	English
Journal	Journal of Musculoskeletal and Neuronal Interactions
Volume	6
Issue number	4
Pages (from-to)	364-5
Number of pages	2
ISSN	1108-7161
Publication status	Published - 2006

Keywords

Aging
Amino Acid Motifs
Animals
Biglycan
Bone and Bones
Coculture Techniques
Decorin
Extracellular Matrix
Extracellular Matrix Proteins
Mice
Mice, Knockout
Models, Animal
Osteoblasts
Osteoclasts
Osteogenesis
Physical Conditioning, Animal
Proteoglycans

Cite this

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title = "Small leucine-rich proteoglycans in the aging skeleton",

abstract = "Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.",

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T1 - Small leucine-rich proteoglycans in the aging skeleton

AU - Young, M F

AU - Bi, Y

AU - Ameye, L

AU - Xu, T

AU - Wadhwa, S

AU - Heegaard, Anne-Marie

AU - Kilts, T

AU - Chen, X D

PY - 2006

Y1 - 2006

N2 - Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.

AB - Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.

KW - Aging

KW - Amino Acid Motifs

KW - Animals

KW - Biglycan

KW - Bone and Bones

KW - Coculture Techniques

KW - Decorin

KW - Extracellular Matrix

KW - Extracellular Matrix Proteins

KW - Mice

KW - Mice, Knockout

KW - Models, Animal

KW - Osteoblasts

KW - Osteoclasts

KW - Osteogenesis

KW - Physical Conditioning, Animal

KW - Proteoglycans

M3 - Journal article

C2 - 17185826

SN - 1108-7161

VL - 6

SP - 364

EP - 365

JO - Journal of Musculoskeletal Neuronal Interactions

JF - Journal of Musculoskeletal Neuronal Interactions

IS - 4

ER -

Small leucine-rich proteoglycans in the aging skeleton

Abstract

Keywords

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