Small-angle scattering studies of intrinsically disordered proteins and their complexes

Tiago N. Cordeiro; Fátima Herranz-Trillo; Annika Urbanek; Alejandro Estaña; Juan Cortés; Nathalie Sibille; Pau Bernadó

doi:10.1016/j.sbi.2016.10.011

Small-angle scattering studies of intrinsically disordered proteins and their complexes

Tiago N. Cordeiro, Fátima Herranz-Trillo, Annika Urbanek, Alejandro Estaña, Juan Cortés, Nathalie Sibille, Pau Bernadó

Xray and Neutron Science

42 Citations (Scopus)

Abstract

Intrinsically Disordered Proteins (IDPs) perform a broad range of biological functions. Their relevance has motivated intense research activity seeking to characterize their sequence/structure/function relationships. However, the conformational plasticity of these molecules hampers the application of traditional structural approaches, and new tools and concepts are being developed to address the challenges they pose. Small-Angle Scattering (SAS) is a structural biology technique that probes the size and shape of disordered proteins and their complexes with other biomolecules. The low-resolution nature of SAS can be compensated with specially designed computational tools and its combined interpretation with complementary structural information. In this review, we describe recent advances in the application of SAS to disordered proteins and highly flexible complexes and discuss current challenges.

Original language	English
Journal	Current Opinion in Structural Biology
Volume	42
Pages (from-to)	15-23
Number of pages	9
ISSN	0959-440X
DOIs	https://doi.org/10.1016/j.sbi.2016.10.011
Publication status	Published - 2017

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title = "Small-angle scattering studies of intrinsically disordered proteins and their complexes",

abstract = "Intrinsically Disordered Proteins (IDPs) perform a broad range of biological functions. Their relevance has motivated intense research activity seeking to characterize their sequence/structure/function relationships. However, the conformational plasticity of these molecules hampers the application of traditional structural approaches, and new tools and concepts are being developed to address the challenges they pose. Small-Angle Scattering (SAS) is a structural biology technique that probes the size and shape of disordered proteins and their complexes with other biomolecules. The low-resolution nature of SAS can be compensated with specially designed computational tools and its combined interpretation with complementary structural information. In this review, we describe recent advances in the application of SAS to disordered proteins and highly flexible complexes and discuss current challenges.",

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T1 - Small-angle scattering studies of intrinsically disordered proteins and their complexes

AU - Cordeiro, Tiago N.

AU - Herranz-Trillo, Fátima

AU - Urbanek, Annika

AU - Estaña, Alejandro

AU - Cortés, Juan

AU - Sibille, Nathalie

AU - Bernadó, Pau

PY - 2017

Y1 - 2017

N2 - Intrinsically Disordered Proteins (IDPs) perform a broad range of biological functions. Their relevance has motivated intense research activity seeking to characterize their sequence/structure/function relationships. However, the conformational plasticity of these molecules hampers the application of traditional structural approaches, and new tools and concepts are being developed to address the challenges they pose. Small-Angle Scattering (SAS) is a structural biology technique that probes the size and shape of disordered proteins and their complexes with other biomolecules. The low-resolution nature of SAS can be compensated with specially designed computational tools and its combined interpretation with complementary structural information. In this review, we describe recent advances in the application of SAS to disordered proteins and highly flexible complexes and discuss current challenges.

AB - Intrinsically Disordered Proteins (IDPs) perform a broad range of biological functions. Their relevance has motivated intense research activity seeking to characterize their sequence/structure/function relationships. However, the conformational plasticity of these molecules hampers the application of traditional structural approaches, and new tools and concepts are being developed to address the challenges they pose. Small-Angle Scattering (SAS) is a structural biology technique that probes the size and shape of disordered proteins and their complexes with other biomolecules. The low-resolution nature of SAS can be compensated with specially designed computational tools and its combined interpretation with complementary structural information. In this review, we describe recent advances in the application of SAS to disordered proteins and highly flexible complexes and discuss current challenges.

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M3 - Review

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SN - 0959-440X

VL - 42

SP - 15

EP - 23

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

ER -

Small-angle scattering studies of intrinsically disordered proteins and their complexes

Abstract

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