Single-sweep spectral analysis of contact heat evoked potentials: a novel approach to identify altered cortical processing after morphine treatment

Tine M Hansen; Carina Graversen; Jens B Frøkjaer; Anne E Olesen; Massimiliano Valeriani; Asbjørn M Drewes

doi:10.1111/bcp.12579

Single-sweep spectral analysis of contact heat evoked potentials: a novel approach to identify altered cortical processing after morphine treatment

Tine M Hansen, Carina Graversen, Jens B Frøkjaer, Anne E Olesen, Massimiliano Valeriani, Asbjørn M Drewes

3 Citations (Scopus)

Abstract

AIMS: The cortical response to nociceptive thermal stimuli recorded as contact heat evoked potentials (CHEPs) may be altered by morphine. However, previous studies have averaged CHEPs over multiple stimuli, which are confounded by jitter between sweeps. Thus, the aim was to assess single-sweep characteristics to identify alterations induced by morphine.

METHODS: In a crossover study 15 single-sweep CHEPs were analyzed from 62 electroencephalography electrodes in 26 healthy volunteers before and after administration of morphine or placebo. Each sweep was decomposed by a continuous wavelet transform to obtain normalized spectral indices in the delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-32 Hz) and gamma (32-80 Hz) bands. The average distribution over all sweeps and channels was calculated for the four recordings for each volunteer, and the two recordings before treatments were assessed for reproducibility. Baseline corrected spectral indices after morphine and placebo treatments were compared to identify alterations induced by morphine.

RESULTS: Reproducibility between baseline CHEPs was demonstrated. As compared with placebo, morphine decreased the spectral indices in the delta and theta bands by 13% (P = 0.04) and 9% (P = 0.007), while the beta and gamma bands were increased by 10% (P = 0.006) and 24% (P = 0.04).

CONCLUSION: The decreases in the delta and theta band are suggested to represent a decrease in the pain specific morphology of the CHEPs, which indicates a diminished pain response after morphine administration. Hence, assessment of spectral indices in single-sweep CHEPs can be used to study cortical mechanisms induced by morphine treatment.

Original language	English
Journal	British Journal of Clinical Pharmacology
Volume	79
Issue number	6
Pages (from-to)	926-36
Number of pages	11
ISSN	0306-5251
DOIs	https://doi.org/10.1111/bcp.12579
Publication status	Published - 1 Jun 2015

Keywords

Adult
Analgesics, Opioid
Brain Waves
Cerebral Cortex
Cross-Over Studies
Denmark
Double-Blind Method
Electroencephalography
Evoked Potentials, Somatosensory
Female
Healthy Volunteers
Hot Temperature
Humans
Male
Morphine
Nociception
Predictive Value of Tests
Reproducibility of Results
Signal Processing, Computer-Assisted
Thermosensing
Time Factors
Young Adult

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Single-sweep spectral analysis of contact heat evoked potentials: a novel approach to identify altered cortical processing after morphine treatment. / Hansen, Tine M; Graversen, Carina; Frøkjaer, Jens B et al.
In: British Journal of Clinical Pharmacology, Vol. 79, No. 6, 01.06.2015, p. 926-36.

Research output: Contribution to journal › Journal article › Research › peer-review

@article{d484917d7fd44c68b1a01597201b62f9,

title = "Single-sweep spectral analysis of contact heat evoked potentials: a novel approach to identify altered cortical processing after morphine treatment",

abstract = "AIMS: The cortical response to nociceptive thermal stimuli recorded as contact heat evoked potentials (CHEPs) may be altered by morphine. However, previous studies have averaged CHEPs over multiple stimuli, which are confounded by jitter between sweeps. Thus, the aim was to assess single-sweep characteristics to identify alterations induced by morphine.METHODS: In a crossover study 15 single-sweep CHEPs were analyzed from 62 electroencephalography electrodes in 26 healthy volunteers before and after administration of morphine or placebo. Each sweep was decomposed by a continuous wavelet transform to obtain normalized spectral indices in the delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-32 Hz) and gamma (32-80 Hz) bands. The average distribution over all sweeps and channels was calculated for the four recordings for each volunteer, and the two recordings before treatments were assessed for reproducibility. Baseline corrected spectral indices after morphine and placebo treatments were compared to identify alterations induced by morphine.RESULTS: Reproducibility between baseline CHEPs was demonstrated. As compared with placebo, morphine decreased the spectral indices in the delta and theta bands by 13% (P = 0.04) and 9% (P = 0.007), while the beta and gamma bands were increased by 10% (P = 0.006) and 24% (P = 0.04).CONCLUSION: The decreases in the delta and theta band are suggested to represent a decrease in the pain specific morphology of the CHEPs, which indicates a diminished pain response after morphine administration. Hence, assessment of spectral indices in single-sweep CHEPs can be used to study cortical mechanisms induced by morphine treatment.",

keywords = "Adult, Analgesics, Opioid, Brain Waves, Cerebral Cortex, Cross-Over Studies, Denmark, Double-Blind Method, Electroencephalography, Evoked Potentials, Somatosensory, Female, Healthy Volunteers, Hot Temperature, Humans, Male, Morphine, Nociception, Predictive Value of Tests, Reproducibility of Results, Signal Processing, Computer-Assisted, Thermosensing, Time Factors, Young Adult",

author = "Hansen, {Tine M} and Carina Graversen and Fr{\o}kjaer, {Jens B} and Olesen, {Anne E} and Massimiliano Valeriani and Drewes, {Asbj{\o}rn M}",

note = "{\textcopyright} 2015 The British Pharmacological Society.",

year = "2015",

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doi = "10.1111/bcp.12579",

language = "English",

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TY - JOUR

T1 - Single-sweep spectral analysis of contact heat evoked potentials

T2 - a novel approach to identify altered cortical processing after morphine treatment

AU - Hansen, Tine M

AU - Graversen, Carina

AU - Frøkjaer, Jens B

AU - Olesen, Anne E

AU - Valeriani, Massimiliano

AU - Drewes, Asbjørn M

PY - 2015/6/1

Y1 - 2015/6/1

N2 - AIMS: The cortical response to nociceptive thermal stimuli recorded as contact heat evoked potentials (CHEPs) may be altered by morphine. However, previous studies have averaged CHEPs over multiple stimuli, which are confounded by jitter between sweeps. Thus, the aim was to assess single-sweep characteristics to identify alterations induced by morphine.METHODS: In a crossover study 15 single-sweep CHEPs were analyzed from 62 electroencephalography electrodes in 26 healthy volunteers before and after administration of morphine or placebo. Each sweep was decomposed by a continuous wavelet transform to obtain normalized spectral indices in the delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-32 Hz) and gamma (32-80 Hz) bands. The average distribution over all sweeps and channels was calculated for the four recordings for each volunteer, and the two recordings before treatments were assessed for reproducibility. Baseline corrected spectral indices after morphine and placebo treatments were compared to identify alterations induced by morphine.RESULTS: Reproducibility between baseline CHEPs was demonstrated. As compared with placebo, morphine decreased the spectral indices in the delta and theta bands by 13% (P = 0.04) and 9% (P = 0.007), while the beta and gamma bands were increased by 10% (P = 0.006) and 24% (P = 0.04).CONCLUSION: The decreases in the delta and theta band are suggested to represent a decrease in the pain specific morphology of the CHEPs, which indicates a diminished pain response after morphine administration. Hence, assessment of spectral indices in single-sweep CHEPs can be used to study cortical mechanisms induced by morphine treatment.

AB - AIMS: The cortical response to nociceptive thermal stimuli recorded as contact heat evoked potentials (CHEPs) may be altered by morphine. However, previous studies have averaged CHEPs over multiple stimuli, which are confounded by jitter between sweeps. Thus, the aim was to assess single-sweep characteristics to identify alterations induced by morphine.METHODS: In a crossover study 15 single-sweep CHEPs were analyzed from 62 electroencephalography electrodes in 26 healthy volunteers before and after administration of morphine or placebo. Each sweep was decomposed by a continuous wavelet transform to obtain normalized spectral indices in the delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-32 Hz) and gamma (32-80 Hz) bands. The average distribution over all sweeps and channels was calculated for the four recordings for each volunteer, and the two recordings before treatments were assessed for reproducibility. Baseline corrected spectral indices after morphine and placebo treatments were compared to identify alterations induced by morphine.RESULTS: Reproducibility between baseline CHEPs was demonstrated. As compared with placebo, morphine decreased the spectral indices in the delta and theta bands by 13% (P = 0.04) and 9% (P = 0.007), while the beta and gamma bands were increased by 10% (P = 0.006) and 24% (P = 0.04).CONCLUSION: The decreases in the delta and theta band are suggested to represent a decrease in the pain specific morphology of the CHEPs, which indicates a diminished pain response after morphine administration. Hence, assessment of spectral indices in single-sweep CHEPs can be used to study cortical mechanisms induced by morphine treatment.

KW - Adult

KW - Analgesics, Opioid

KW - Brain Waves

KW - Cerebral Cortex

KW - Cross-Over Studies

KW - Denmark

KW - Double-Blind Method

KW - Electroencephalography

KW - Evoked Potentials, Somatosensory

KW - Female

KW - Healthy Volunteers

KW - Hot Temperature

KW - Humans

KW - Male

KW - Morphine

KW - Nociception

KW - Predictive Value of Tests

KW - Reproducibility of Results

KW - Signal Processing, Computer-Assisted

KW - Thermosensing

KW - Time Factors

KW - Young Adult

U2 - 10.1111/bcp.12579

DO - 10.1111/bcp.12579

M3 - Journal article

C2 - 25556985

SN - 0306-5251

VL - 79

SP - 926

EP - 936

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 6

ER -

Single-sweep spectral analysis of contact heat evoked potentials: a novel approach to identify altered cortical processing after morphine treatment

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Keywords

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