Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation

Kristoffer M A Henningsen; Morten S Olesen; Maria Pedersen; Lone Nielsen; Stig Haunsø; Helle Bruunsgaard; Jesper Hastrup Svendsen; Kristoffer M A Henningsen; Morten S Olesen; Maria Pedersen; Lone Nielsen; Stig Haunsø; Helle Bruunsgaard; Jesper Hastrup Svendsen

doi:10.1007/s00011-010-0210-8

Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation

Kristoffer M A Henningsen, Morten S Olesen, Maria Pedersen, Lone Nielsen, Stig Haunsø, Helle Bruunsgaard, Jesper Hastrup Svendsen, Kristoffer M A Henningsen, Morten S Olesen, Maria Pedersen, Lone Nielsen, Stig Haunsø, Helle Bruunsgaard, Jesper Hastrup Svendsen

7 Citations (Scopus)

Abstract

Background: Systemic low-grade inflammation is a prognostic risk factor of atrial fibrillation (AF). Objective: We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with the risk of AF, independently of comorbidity. Methods and results: We included 192 patients with socalled lone AF and age 40 years or below, and 188 healthy controls. All patients were genotyped for single nucleotide polymorphisms (SNPs) in inflammatory genes using fluorescence-based real-time polymerase chain reaction (PCR). A case-control analysis of the C/C, C/T and T/T genotypes on IL1A-889 revealed a significant difference in both the frequency of genotypes (p = 0.03) and in the allelic frequency (p = 0.015). These differences were not significant after Bonferroni corrections. For IL1B-511, IL10-592, IL10-1082, IL18-137, IL18-607 and TNF-308 there were no significant differences, neither in genotype frequency, nor in allelic frequency between the lone AF patients and the controls. Conclusion: Our study failed to show an association between polymorphisms in inflammatory genes and early onset of lone AF. It remains to be established whether polymorphisms in inflammatory genes play a causative role in the pathophysiology of AF.

Original language	English
Journal	Inflammation Research
Volume	59
Issue number	11
Pages (from-to)	965-9
Number of pages	5
ISSN	1023-3830
DOIs	https://doi.org/10.1007/s00011-010-0210-8
Publication status	Published - 1 Nov 2010

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Henningsen, K. M. A., Olesen, M. S., Pedersen, M., Nielsen, L., Haunsø, S., Bruunsgaard, H., Svendsen, J. H., Henningsen, K. M. A., Olesen, M. S., Pedersen, M., Nielsen, L., Haunsø, S., Bruunsgaard, H., & Svendsen, J. H. (2010). Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation. Inflammation Research, 59(11), 965-9. https://doi.org/10.1007/s00011-010-0210-8

Henningsen, KMA, Olesen, MS, Pedersen, M, Nielsen, L, Haunsø, S, Bruunsgaard, H, Svendsen, JH, Henningsen, KMA, Olesen, MS, Pedersen, M, Nielsen, L, Haunsø, S, Bruunsgaard, H & Svendsen, JH 2010, 'Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation', Inflammation Research, vol. 59, no. 11, pp. 965-9. https://doi.org/10.1007/s00011-010-0210-8

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title = "Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation",

abstract = "Background: Systemic low-grade inflammation is a prognostic risk factor of atrial fibrillation (AF). Objective: We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with the risk of AF, independently of comorbidity. Methods and results: We included 192 patients with socalled lone AF and age 40 years or below, and 188 healthy controls. All patients were genotyped for single nucleotide polymorphisms (SNPs) in inflammatory genes using fluorescence-based real-time polymerase chain reaction (PCR). A case-control analysis of the C/C, C/T and T/T genotypes on IL1A-889 revealed a significant difference in both the frequency of genotypes (p = 0.03) and in the allelic frequency (p = 0.015). These differences were not significant after Bonferroni corrections. For IL1B-511, IL10-592, IL10-1082, IL18-137, IL18-607 and TNF-308 there were no significant differences, neither in genotype frequency, nor in allelic frequency between the lone AF patients and the controls. Conclusion: Our study failed to show an association between polymorphisms in inflammatory genes and early onset of lone AF. It remains to be established whether polymorphisms in inflammatory genes play a causative role in the pathophysiology of AF.",

author = "Henningsen, {Kristoffer M A} and Olesen, {Morten S} and Maria Pedersen and Lone Nielsen and Stig Hauns{\o} and Helle Bruunsgaard and Svendsen, {Jesper Hastrup} and Henningsen, {Kristoffer M A} and Olesen, {Morten S} and Maria Pedersen and Lone Nielsen and Stig Hauns{\o} and Helle Bruunsgaard and Svendsen, {Jesper Hastrup}",

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T1 - Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation

AU - Henningsen, Kristoffer M A

AU - Olesen, Morten S

AU - Pedersen, Maria

AU - Nielsen, Lone

AU - Haunsø, Stig

AU - Bruunsgaard, Helle

AU - Svendsen, Jesper Hastrup

AU - Henningsen, Kristoffer M A

AU - Olesen, Morten S

AU - Pedersen, Maria

AU - Nielsen, Lone

AU - Haunsø, Stig

AU - Bruunsgaard, Helle

AU - Svendsen, Jesper Hastrup

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Background: Systemic low-grade inflammation is a prognostic risk factor of atrial fibrillation (AF). Objective: We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with the risk of AF, independently of comorbidity. Methods and results: We included 192 patients with socalled lone AF and age 40 years or below, and 188 healthy controls. All patients were genotyped for single nucleotide polymorphisms (SNPs) in inflammatory genes using fluorescence-based real-time polymerase chain reaction (PCR). A case-control analysis of the C/C, C/T and T/T genotypes on IL1A-889 revealed a significant difference in both the frequency of genotypes (p = 0.03) and in the allelic frequency (p = 0.015). These differences were not significant after Bonferroni corrections. For IL1B-511, IL10-592, IL10-1082, IL18-137, IL18-607 and TNF-308 there were no significant differences, neither in genotype frequency, nor in allelic frequency between the lone AF patients and the controls. Conclusion: Our study failed to show an association between polymorphisms in inflammatory genes and early onset of lone AF. It remains to be established whether polymorphisms in inflammatory genes play a causative role in the pathophysiology of AF.

AB - Background: Systemic low-grade inflammation is a prognostic risk factor of atrial fibrillation (AF). Objective: We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with the risk of AF, independently of comorbidity. Methods and results: We included 192 patients with socalled lone AF and age 40 years or below, and 188 healthy controls. All patients were genotyped for single nucleotide polymorphisms (SNPs) in inflammatory genes using fluorescence-based real-time polymerase chain reaction (PCR). A case-control analysis of the C/C, C/T and T/T genotypes on IL1A-889 revealed a significant difference in both the frequency of genotypes (p = 0.03) and in the allelic frequency (p = 0.015). These differences were not significant after Bonferroni corrections. For IL1B-511, IL10-592, IL10-1082, IL18-137, IL18-607 and TNF-308 there were no significant differences, neither in genotype frequency, nor in allelic frequency between the lone AF patients and the controls. Conclusion: Our study failed to show an association between polymorphisms in inflammatory genes and early onset of lone AF. It remains to be established whether polymorphisms in inflammatory genes play a causative role in the pathophysiology of AF.

U2 - 10.1007/s00011-010-0210-8

DO - 10.1007/s00011-010-0210-8

M3 - Journal article

C2 - 20490891

SN - 1023-3830

VL - 59

SP - 965

EP - 969

JO - Inflammation Research

JF - Inflammation Research

IS - 11

ER -

Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation

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