Simultaneous Increase in Brightness and Singlet Oxygen Generation of an Organic Photosensitizer by Nanocrystallization

S. M. Ali Fateminia; Laura Kacenauskaite; Chong-jing Zhang; Suqian Ma; null Kenry; Purnima N. Manghnani; Junsheng Chen; Shidang Xu; Fang Hu; Bin Xu; Bo W. Laursen; Bin Liu

doi:10.1002/smll.201803325

Simultaneous Increase in Brightness and Singlet Oxygen Generation of an Organic Photosensitizer by Nanocrystallization

S. M. Ali Fateminia, Laura Kacenauskaite, Chong-jing Zhang, Suqian Ma, Kenry, Purnima N. Manghnani, Junsheng Chen, Shidang Xu, Fang Hu, Bin Xu, Bo W. Laursen, Bin Liu

13 Citations (Scopus)

Abstract

Efficient organic photosensitizers are attractive for cancer cell ablation in photodynamic therapy. Bright fluorescent photosensitizers are highly desirable for simultaneous imaging and therapy. However, due to fundamental competition between emission and singlet oxygen generation, design attempts to increase singlet oxygen generation almost always leads to the loss of fluorescence. Herein, it is shown for the first time that nanocrystallization enables a simultaneous and significant increase in the brightness and singlet oxygen generation of an organic photosensitizer. Spectroscopic studies show simultaneous enhancement in the visible light absorption and fluorescence after nanocrystallization. The enhanced absorption of visible light in nanocrystals is found to translate directly to the enhanced singlet oxygen production, which shows a higher ability to kill HeLa cells as compared to their amorphous counterpart.

Original language	English
Article number	1803325
Journal	Small
Volume	14
Issue number	52
Pages (from-to)	1-6
Number of pages	6
ISSN	1613-6810
DOIs	https://doi.org/10.1002/smll.201803325
Publication status	Published - 27 Dec 2018

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title = "Simultaneous Increase in Brightness and Singlet Oxygen Generation of an Organic Photosensitizer by Nanocrystallization",

abstract = "Efficient organic photosensitizers are attractive for cancer cell ablation in photodynamic therapy. Bright fluorescent photosensitizers are highly desirable for simultaneous imaging and therapy. However, due to fundamental competition between emission and singlet oxygen generation, design attempts to increase singlet oxygen generation almost always leads to the loss of fluorescence. Herein, it is shown for the first time that nanocrystallization enables a simultaneous and significant increase in the brightness and singlet oxygen generation of an organic photosensitizer. Spectroscopic studies show simultaneous enhancement in the visible light absorption and fluorescence after nanocrystallization. The enhanced absorption of visible light in nanocrystals is found to translate directly to the enhanced singlet oxygen production, which shows a higher ability to kill HeLa cells as compared to their amorphous counterpart.",

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doi = "10.1002/smll.201803325",

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T1 - Simultaneous Increase in Brightness and Singlet Oxygen Generation of an Organic Photosensitizer by Nanocrystallization

AU - Fateminia, S. M. Ali

AU - Kacenauskaite, Laura

AU - Zhang, Chong-jing

AU - Ma, Suqian

AU - Kenry, null

AU - Manghnani, Purnima N.

AU - Chen, Junsheng

AU - Xu, Shidang

AU - Hu, Fang

AU - Xu, Bin

AU - Laursen, Bo W.

AU - Liu, Bin

PY - 2018/12/27

Y1 - 2018/12/27

N2 - Efficient organic photosensitizers are attractive for cancer cell ablation in photodynamic therapy. Bright fluorescent photosensitizers are highly desirable for simultaneous imaging and therapy. However, due to fundamental competition between emission and singlet oxygen generation, design attempts to increase singlet oxygen generation almost always leads to the loss of fluorescence. Herein, it is shown for the first time that nanocrystallization enables a simultaneous and significant increase in the brightness and singlet oxygen generation of an organic photosensitizer. Spectroscopic studies show simultaneous enhancement in the visible light absorption and fluorescence after nanocrystallization. The enhanced absorption of visible light in nanocrystals is found to translate directly to the enhanced singlet oxygen production, which shows a higher ability to kill HeLa cells as compared to their amorphous counterpart.

AB - Efficient organic photosensitizers are attractive for cancer cell ablation in photodynamic therapy. Bright fluorescent photosensitizers are highly desirable for simultaneous imaging and therapy. However, due to fundamental competition between emission and singlet oxygen generation, design attempts to increase singlet oxygen generation almost always leads to the loss of fluorescence. Herein, it is shown for the first time that nanocrystallization enables a simultaneous and significant increase in the brightness and singlet oxygen generation of an organic photosensitizer. Spectroscopic studies show simultaneous enhancement in the visible light absorption and fluorescence after nanocrystallization. The enhanced absorption of visible light in nanocrystals is found to translate directly to the enhanced singlet oxygen production, which shows a higher ability to kill HeLa cells as compared to their amorphous counterpart.

U2 - 10.1002/smll.201803325

DO - 10.1002/smll.201803325

M3 - Letter

C2 - 30480358

SN - 1613-6810

VL - 14

SP - 1

EP - 6

JO - Small

JF - Small

IS - 52

M1 - 1803325

ER -

Simultaneous Increase in Brightness and Singlet Oxygen Generation of an Organic Photosensitizer by Nanocrystallization

Abstract

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