Short-term side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors

Simon Pahnke; Gunnar Larfors; Ulla Axdorph-nygell; Anne Fischer-nielsen; Eva Haastrup; Dag Heldal; Maija Itälä-remes; Jan-erik Johansson; Marjut Kauppila; Stig Lenhoff; Per Ljungman; Riita Niittyvuopio; Anna Sandstedt; Hans Hägglund

doi:10.1002/jca.v33.3

Short-term side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors

Simon Pahnke, Gunnar Larfors, Ulla Axdorph-nygell, Anne Fischer-nielsen, Eva Haastrup, Dag Heldal, Maija Itälä-remes, Jan-erik Johansson, Marjut Kauppila, Stig Lenhoff, Per Ljungman, Riita Niittyvuopio, Anna Sandstedt, Hans Hägglund

2 Citations (Scopus)

Abstract

The Nordic Register of Haematopoietic Stem Cell Donors (NRHSD) has registered related and unrelated donors from 10 transplant centres in Sweden, Norway, Finland and Denmark since 1998. We present a prospective, observational study of 1,957 donors, focusing mainly on the differences between related and unrelated donors. Related donors are reported to have more comorbidities, but similar side effects compared with unrelated donors. Side effects after BM or PBSC donation are generally of short duration and in this study no deaths, myocardial infarctions, splenic ruptures, or thromboembolic events are reported. Interestingly, related donors express more hesitancy towards donating again when asked 1 month after donation.

Original language	English
Journal	Journal of Clinical Apheresis
Volume	33
Issue number	3
Pages (from-to)	226-235
ISSN	0733-2459
DOIs	https://doi.org/10.1002/jca.v33.3
Publication status	Published - Jun 2018

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Pahnke, S., Larfors, G., Axdorph-nygell, U., Fischer-nielsen, A., Haastrup, E., Heldal, D., Itälä-remes, M., Johansson, J., Kauppila, M., Lenhoff, S., Ljungman, P., Niittyvuopio, R., Sandstedt, A., & Hägglund, H. (2018). Short-term side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors . Journal of Clinical Apheresis, 33(3), 226-235. https://doi.org/10.1002/jca.v33.3

Pahnke, S, Larfors, G, Axdorph-nygell, U, Fischer-nielsen, A, Haastrup, E, Heldal, D, Itälä-remes, M, Johansson, J, Kauppila, M, Lenhoff, S, Ljungman, P, Niittyvuopio, R, Sandstedt, A & Hägglund, H 2018, 'Short-term side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors ', Journal of Clinical Apheresis, vol. 33, no. 3, pp. 226-235. https://doi.org/10.1002/jca.v33.3

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abstract = "The Nordic Register of Haematopoietic Stem Cell Donors (NRHSD) has registered related and unrelated donors from 10 transplant centres in Sweden, Norway, Finland and Denmark since 1998. We present a prospective, observational study of 1,957 donors, focusing mainly on the differences between related and unrelated donors. Related donors are reported to have more comorbidities, but similar side effects compared with unrelated donors. Side effects after BM or PBSC donation are generally of short duration and in this study no deaths, myocardial infarctions, splenic ruptures, or thromboembolic events are reported. Interestingly, related donors express more hesitancy towards donating again when asked 1 month after donation.",

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AU - Pahnke, Simon

AU - Larfors, Gunnar

AU - Axdorph-nygell, Ulla

AU - Fischer-nielsen, Anne

AU - Haastrup, Eva

AU - Heldal, Dag

AU - Itälä-remes, Maija

AU - Johansson, Jan-erik

AU - Kauppila, Marjut

AU - Lenhoff, Stig

AU - Ljungman, Per

AU - Niittyvuopio, Riita

AU - Sandstedt, Anna

AU - Hägglund, Hans

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N2 - The Nordic Register of Haematopoietic Stem Cell Donors (NRHSD) has registered related and unrelated donors from 10 transplant centres in Sweden, Norway, Finland and Denmark since 1998. We present a prospective, observational study of 1,957 donors, focusing mainly on the differences between related and unrelated donors. Related donors are reported to have more comorbidities, but similar side effects compared with unrelated donors. Side effects after BM or PBSC donation are generally of short duration and in this study no deaths, myocardial infarctions, splenic ruptures, or thromboembolic events are reported. Interestingly, related donors express more hesitancy towards donating again when asked 1 month after donation.

AB - The Nordic Register of Haematopoietic Stem Cell Donors (NRHSD) has registered related and unrelated donors from 10 transplant centres in Sweden, Norway, Finland and Denmark since 1998. We present a prospective, observational study of 1,957 donors, focusing mainly on the differences between related and unrelated donors. Related donors are reported to have more comorbidities, but similar side effects compared with unrelated donors. Side effects after BM or PBSC donation are generally of short duration and in this study no deaths, myocardial infarctions, splenic ruptures, or thromboembolic events are reported. Interestingly, related donors express more hesitancy towards donating again when asked 1 month after donation.

U2 - 10.1002/jca.v33.3

DO - 10.1002/jca.v33.3

M3 - Journal article

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EP - 235

JO - Journal of Clinical Apheresis

JF - Journal of Clinical Apheresis

IS - 3

ER -

Short-term side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors

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