Short- and long-term effects of endurance training in patients with mitochondrial myopathy

T D Jeppesen; M Dunø; M Schwartz; T Krag; J Rafiq; F Wibrand; J Vissing

doi:10.1111/j.1468-1331.2009.02660.x

Short- and long-term effects of endurance training in patients with mitochondrial myopathy

T D Jeppesen, M Dunø, M Schwartz, T Krag, J Rafiq, F Wibrand, J Vissing

Teaching

28 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

Original language	English
Journal	European Journal of Neurology
Volume	16
Issue number	12
Pages (from-to)	1336-9
Number of pages	3
ISSN	1351-5101
DOIs	https://doi.org/10.1111/j.1468-1331.2009.02660.x
Publication status	Published - 2009

Access to Document

10.1111/j.1468-1331.2009.02660.x

Cite this

@article{fe581540359c11df8ed1000ea68e967b,

title = "Short- and long-term effects of endurance training in patients with mitochondrial myopathy",

abstract = "BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.",

author = "Jeppesen, {T D} and M Dun{\o} and M Schwartz and T Krag and J Rafiq and F Wibrand and J Vissing",

note = "Keywords: Exercise Therapy; Exercise Tolerance; Humans; Mitochondrial Myopathies; Muscle, Skeletal; Time",

year = "2009",

doi = "10.1111/j.1468-1331.2009.02660.x",

language = "English",

volume = "16",

pages = "1336--9",

journal = "European Journal of Neurology",

issn = "1351-5101",

publisher = "Wiley-Blackwell",

number = "12",

}

TY - JOUR

T1 - Short- and long-term effects of endurance training in patients with mitochondrial myopathy

AU - Jeppesen, T D

AU - Dunø, M

AU - Schwartz, M

AU - Krag, T

AU - Rafiq, J

AU - Wibrand, F

AU - Vissing, J

N1 - Keywords: Exercise Therapy; Exercise Tolerance; Humans; Mitochondrial Myopathies; Muscle, Skeletal; Time

PY - 2009

Y1 - 2009

N2 - BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

AB - BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

U2 - 10.1111/j.1468-1331.2009.02660.x

DO - 10.1111/j.1468-1331.2009.02660.x

M3 - Journal article

C2 - 19486129

SN - 1351-5101

VL - 16

SP - 1336

EP - 1339

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 12

ER -

Short- and long-term effects of endurance training in patients with mitochondrial myopathy

Abstract

Access to Document

Fingerprint

Cite this