Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21

TY - JOUR

T1 - Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21

AU - Ostrom, Quinn T

AU - Kinnersley, Ben

AU - Wrensch, Margaret R

AU - Eckel-Passow, Jeanette E

AU - Armstrong, Georgina

AU - Rice, Terri

AU - Chen, Yanwen

AU - Wiencke, John K

AU - McCoy, Lucie S

AU - Hansen, Helen M

AU - Amos, Christopher I

AU - Bernstein, Jonine L

AU - Claus, Elizabeth B

AU - Il'yasova, Dora

AU - Johansen, Christoffer

AU - Lachance, Daniel H

AU - Lai, Rose K

AU - Merrell, Ryan T

AU - Olson, Sara H

AU - Sadetzki, Siegal

AU - Schildkraut, Joellen M

AU - Shete, Sanjay

AU - Rubin, Joshua B

AU - Lathia, Justin D

AU - Berens, Michael E

AU - Andersson, Ulrika

AU - Rajaraman, Preetha

AU - Chanock, Stephen J

AU - Linet, Martha S

AU - Wang, Zhaoming

AU - Yeager, Meredith

AU - GliomaScan Consortium

AU - Houlston, Richard S

AU - Jenkins, Robert B

AU - Melin, Beatrice

AU - Bondy, Melissa L

AU - Barnholtz-Sloan, Jill S

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.

AB - Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.

U2 - 10.1038/s41598-018-24580-z

DO - 10.1038/s41598-018-24580-z

M3 - Journal article

C2 - 29743610

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

M1 - 7352

ER -