Sex, smoking, and socioeconomic status are associated with body composition among tuberculosis patients in a Deuterium Dilution Cross-Sectional study in Mwanza, Tanzania

George PrayGod; Nyagosya Range; Daniel Faurholt-Jepsen; Kidola Jeremiah; Maria Faurholt-Jepsen; Martine G. Aabye; Pascal Magnussen; John Changalucha; Åse Bengård Andersen; Jonathan C. K. Wells; Henrik Friis

doi:10.3945/jn.112.168997

Sex, smoking, and socioeconomic status are associated with body composition among tuberculosis patients in a Deuterium Dilution Cross-Sectional study in Mwanza, Tanzania

George PrayGod, Nyagosya Range, Daniel Faurholt-Jepsen, Kidola Jeremiah, Maria Faurholt-Jepsen, Martine G. Aabye, Pascal Magnussen, John Changalucha, Åse Bengård Andersen, Jonathan C. K. Wells, Henrik Friis

7 Citations (Scopus)

Abstract

Underweight is common among tuberculosis (TB) patients. However, there is little information on determinants of body composition at TB treatment initiation in high-TB-burdened countries. This study aimed to determine factors associated with body composition at commencement of TB treatment in Mwanza, Tanzania. A cross-sectional study was conducted from 2007 to 2008 among newly diagnosed TB patients. Fat and fat-free mass were determined using a deuterium dilution technique and fat and fat-free mass indices were computed. Correlates were assessed using multiple regression analysis. A total of 201 pulmonary TB patients were recruited; of these, 37.8% (76) were female, 51.7% (104) were HIV infected, 65.3% (126) had sputum-positive TB, and 24.4% (49) were current smokers. In multiple regressions analysis, males had a 2.2-kg/m² [(95% CI = 1.6, 2.9); P < 0.0001] lower fat mass index but 1.5 kg/m² [(95% CI = 0.9, 2.0); P < 0.0001] higher fatfree mass index compared with females. Sputum-positive TB was associated with a lower fat mass index among HIVuninfected patients [-1.4 kg (95% CI = -2.5,-0.4); P = 0.006] but not among HIV-infected patients (P-interaction = 0.09). Current smokers had a 0.7-kg/m² [(95% CI = 0.02, 1.5); P = 0.045] lower fat mass index, but smoking did not affect fat-free mass. High socioeconomic status (SES) was associated with higher fat as well as fat-free mass. HIV infection, cluster of differentiation 4 count, and antiretroviral therapy were not correlates. Sex, smoking, and SES were associated with body composition of TB patients at treatment commencement. Prospective studies are needed to determine the role of these factors on weight gain, functional recovery, and survival during and after treatment.

Original language	English
Journal	Journal of Nutrition
Volume	143
Issue number	5
Pages (from-to)	735-741
Number of pages	7
ISSN	0022-3166
DOIs	https://doi.org/10.3945/jn.112.168997
Publication status	Published - May 2013

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10.3945/jn.112.168997

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PrayGod, G., Range, N., Faurholt-Jepsen, D., Jeremiah, K., Faurholt-Jepsen, M., Aabye, M. G., Magnussen, P., Changalucha, J., Andersen, Å. B., Wells, J. C. K., & Friis, H. (2013). Sex, smoking, and socioeconomic status are associated with body composition among tuberculosis patients in a Deuterium Dilution Cross-Sectional study in Mwanza, Tanzania. Journal of Nutrition, 143(5), 735-741. https://doi.org/10.3945/jn.112.168997

Sex, smoking, and socioeconomic status are associated with body composition among tuberculosis patients in a Deuterium Dilution Cross-Sectional study in Mwanza, Tanzania. / PrayGod, George; Range, Nyagosya; Faurholt-Jepsen, Daniel et al.

In: Journal of Nutrition, Vol. 143, No. 5, 05.2013, p. 735-741.

Research output: Contribution to journal › Journal article › Research › peer-review

PrayGod, G, Range, N, Faurholt-Jepsen, D, Jeremiah, K, Faurholt-Jepsen, M, Aabye, MG, Magnussen, P, Changalucha, J, Andersen, ÅB, Wells, JCK & Friis, H 2013, 'Sex, smoking, and socioeconomic status are associated with body composition among tuberculosis patients in a Deuterium Dilution Cross-Sectional study in Mwanza, Tanzania', Journal of Nutrition, vol. 143, no. 5, pp. 735-741. https://doi.org/10.3945/jn.112.168997

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title = "Sex, smoking, and socioeconomic status are associated with body composition among tuberculosis patients in a Deuterium Dilution Cross-Sectional study in Mwanza, Tanzania",

abstract = "Underweight is common among tuberculosis (TB) patients. However, there is little information on determinants of body composition at TB treatment initiation in high-TB-burdened countries. This study aimed to determine factors associated with body composition at commencement of TB treatment in Mwanza, Tanzania. A cross-sectional study was conducted from 2007 to 2008 among newly diagnosed TB patients. Fat and fat-free mass were determined using a deuterium dilution technique and fat and fat-free mass indices were computed. Correlates were assessed using multiple regression analysis. A total of 201 pulmonary TB patients were recruited; of these, 37.8% (76) were female, 51.7% (104) were HIV infected, 65.3% (126) had sputum-positive TB, and 24.4% (49) were current smokers. In multiple regressions analysis, males had a 2.2-kg/m2 [(95% CI = 1.6, 2.9); P < 0.0001] lower fat mass index but 1.5 kg/m2 [(95% CI = 0.9, 2.0); P < 0.0001] higher fatfree mass index compared with females. Sputum-positive TB was associated with a lower fat mass index among HIVuninfected patients [-1.4 kg (95% CI = -2.5,-0.4); P = 0.006] but not among HIV-infected patients (P-interaction = 0.09). Current smokers had a 0.7-kg/m2 [(95% CI = 0.02, 1.5); P = 0.045] lower fat mass index, but smoking did not affect fat-free mass. High socioeconomic status (SES) was associated with higher fat as well as fat-free mass. HIV infection, cluster of differentiation 4 count, and antiretroviral therapy were not correlates. Sex, smoking, and SES were associated with body composition of TB patients at treatment commencement. Prospective studies are needed to determine the role of these factors on weight gain, functional recovery, and survival during and after treatment.",

author = "George PrayGod and Nyagosya Range and Daniel Faurholt-Jepsen and Kidola Jeremiah and Maria Faurholt-Jepsen and Aabye, {Martine G.} and Pascal Magnussen and John Changalucha and Andersen, {{\AA}se Beng{\aa}rd} and Wells, {Jonathan C. K.} and Henrik Friis",

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T1 - Sex, smoking, and socioeconomic status are associated with body composition among tuberculosis patients in a Deuterium Dilution Cross-Sectional study in Mwanza, Tanzania

AU - PrayGod, George

AU - Range, Nyagosya

AU - Faurholt-Jepsen, Daniel

AU - Jeremiah, Kidola

AU - Faurholt-Jepsen, Maria

AU - Aabye, Martine G.

AU - Magnussen, Pascal

AU - Changalucha, John

AU - Andersen, Åse Bengård

AU - Wells, Jonathan C. K.

AU - Friis, Henrik

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N2 - Underweight is common among tuberculosis (TB) patients. However, there is little information on determinants of body composition at TB treatment initiation in high-TB-burdened countries. This study aimed to determine factors associated with body composition at commencement of TB treatment in Mwanza, Tanzania. A cross-sectional study was conducted from 2007 to 2008 among newly diagnosed TB patients. Fat and fat-free mass were determined using a deuterium dilution technique and fat and fat-free mass indices were computed. Correlates were assessed using multiple regression analysis. A total of 201 pulmonary TB patients were recruited; of these, 37.8% (76) were female, 51.7% (104) were HIV infected, 65.3% (126) had sputum-positive TB, and 24.4% (49) were current smokers. In multiple regressions analysis, males had a 2.2-kg/m2 [(95% CI = 1.6, 2.9); P < 0.0001] lower fat mass index but 1.5 kg/m2 [(95% CI = 0.9, 2.0); P < 0.0001] higher fatfree mass index compared with females. Sputum-positive TB was associated with a lower fat mass index among HIVuninfected patients [-1.4 kg (95% CI = -2.5,-0.4); P = 0.006] but not among HIV-infected patients (P-interaction = 0.09). Current smokers had a 0.7-kg/m2 [(95% CI = 0.02, 1.5); P = 0.045] lower fat mass index, but smoking did not affect fat-free mass. High socioeconomic status (SES) was associated with higher fat as well as fat-free mass. HIV infection, cluster of differentiation 4 count, and antiretroviral therapy were not correlates. Sex, smoking, and SES were associated with body composition of TB patients at treatment commencement. Prospective studies are needed to determine the role of these factors on weight gain, functional recovery, and survival during and after treatment.

AB - Underweight is common among tuberculosis (TB) patients. However, there is little information on determinants of body composition at TB treatment initiation in high-TB-burdened countries. This study aimed to determine factors associated with body composition at commencement of TB treatment in Mwanza, Tanzania. A cross-sectional study was conducted from 2007 to 2008 among newly diagnosed TB patients. Fat and fat-free mass were determined using a deuterium dilution technique and fat and fat-free mass indices were computed. Correlates were assessed using multiple regression analysis. A total of 201 pulmonary TB patients were recruited; of these, 37.8% (76) were female, 51.7% (104) were HIV infected, 65.3% (126) had sputum-positive TB, and 24.4% (49) were current smokers. In multiple regressions analysis, males had a 2.2-kg/m2 [(95% CI = 1.6, 2.9); P < 0.0001] lower fat mass index but 1.5 kg/m2 [(95% CI = 0.9, 2.0); P < 0.0001] higher fatfree mass index compared with females. Sputum-positive TB was associated with a lower fat mass index among HIVuninfected patients [-1.4 kg (95% CI = -2.5,-0.4); P = 0.006] but not among HIV-infected patients (P-interaction = 0.09). Current smokers had a 0.7-kg/m2 [(95% CI = 0.02, 1.5); P = 0.045] lower fat mass index, but smoking did not affect fat-free mass. High socioeconomic status (SES) was associated with higher fat as well as fat-free mass. HIV infection, cluster of differentiation 4 count, and antiretroviral therapy were not correlates. Sex, smoking, and SES were associated with body composition of TB patients at treatment commencement. Prospective studies are needed to determine the role of these factors on weight gain, functional recovery, and survival during and after treatment.

U2 - 10.3945/jn.112.168997

DO - 10.3945/jn.112.168997

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C2 - 23514764

SN - 0022-3166

VL - 143

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JO - Journal of Nutrition

JF - Journal of Nutrition

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ER -

Sex, smoking, and socioeconomic status are associated with body composition among tuberculosis patients in a Deuterium Dilution Cross-Sectional study in Mwanza, Tanzania

Abstract

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