Serum concentrations of mast cell tryptase are reduced in heavy drinkers

Carmen Beceiro; Joaquín Campos; Maria-Angeles Valcarcel; Runa V Fenger; Santiago Lojo; Allan Linneberg; Carmen Vidal; Arturo Gonzalez-Quintela

doi:10.1111/acer.12682

Serum concentrations of mast cell tryptase are reduced in heavy drinkers

Carmen Beceiro, Joaquín Campos, Maria-Angeles Valcarcel, Runa V Fenger, Santiago Lojo, Allan Linneberg, Carmen Vidal, Arturo Gonzalez-Quintela

3 Citations (Scopus)

Abstract

Background: Baseline serum tryptase concentrations are commonly used in clinical practice as a marker of the body's mast cell burden. This study aimed to investigate serum tryptase concentrations in heavy drinkers. Methods: Serum tryptase concentrations were determined in 126 heavy drinkers (75% males, median age 47 years) who were admitted to the hospital because of alcohol withdrawal syndrome (n = 60), general symptoms with abnormalities on biochemical tests that indicated acute liver disease (n = 19), complications of advanced liver disease (n = 33), and miscellaneous reasons (n = 14). Results were compared with those of 70 healthy controls (66% males, median age 40 years). Results: Serum tryptase concentrations were lower in heavy drinkers than in healthy controls (median 2.23 μg/l vs. median 3.25 μg/l, p < 0.001). Ten heavy drinkers (7.9%) had undetectable (<1 μg/l) serum tryptase levels versus none of the healthy controls (p = 0.01). The association of low tryptase levels with heavy drinking was independent of age, gender, and smoking status. Among heavy drinkers, the lowest tryptase concentrations were observed in patients with alcohol withdrawal syndrome and patients with general symptoms with abnormalities on biochemical tests that indicated acute liver disease. Furthermore, serum tryptase concentrations were negatively correlated with markers of acute liver damage or alcohol consumption (serum aspartate aminotransferase and gamma-glutamyl transferase). Atopy (skin prick test positivity) was not associated with serum tryptase concentrations in heavy drinkers. Conclusions: Serum concentrations of mast cell tryptase are lower in heavy drinkers than in healthy controls.

Original language	English
Journal	Alcoholism: Clinical and Experimental Research
Volume	39
Issue number	4
Pages (from-to)	672-8
Number of pages	7
ISSN	0145-6008
DOIs	https://doi.org/10.1111/acer.12682
Publication status	Published - 1 Apr 2015

Keywords

Adult
Alcohol Drinking
Biomarkers
Case-Control Studies
Female
Humans
Liver Diseases, Alcoholic
Male
Mast Cells
Middle Aged
Substance Withdrawal Syndrome
Tryptases

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10.1111/acer.12682

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@article{85943d3affc84b2db9615501d3203b81,

title = "Serum concentrations of mast cell tryptase are reduced in heavy drinkers",

abstract = "Background: Baseline serum tryptase concentrations are commonly used in clinical practice as a marker of the body's mast cell burden. This study aimed to investigate serum tryptase concentrations in heavy drinkers. Methods: Serum tryptase concentrations were determined in 126 heavy drinkers (75% males, median age 47 years) who were admitted to the hospital because of alcohol withdrawal syndrome (n = 60), general symptoms with abnormalities on biochemical tests that indicated acute liver disease (n = 19), complications of advanced liver disease (n = 33), and miscellaneous reasons (n = 14). Results were compared with those of 70 healthy controls (66% males, median age 40 years). Results: Serum tryptase concentrations were lower in heavy drinkers than in healthy controls (median 2.23 μg/l vs. median 3.25 μg/l, p < 0.001). Ten heavy drinkers (7.9%) had undetectable (<1 μg/l) serum tryptase levels versus none of the healthy controls (p = 0.01). The association of low tryptase levels with heavy drinking was independent of age, gender, and smoking status. Among heavy drinkers, the lowest tryptase concentrations were observed in patients with alcohol withdrawal syndrome and patients with general symptoms with abnormalities on biochemical tests that indicated acute liver disease. Furthermore, serum tryptase concentrations were negatively correlated with markers of acute liver damage or alcohol consumption (serum aspartate aminotransferase and gamma-glutamyl transferase). Atopy (skin prick test positivity) was not associated with serum tryptase concentrations in heavy drinkers. Conclusions: Serum concentrations of mast cell tryptase are lower in heavy drinkers than in healthy controls.",

keywords = "Adult, Alcohol Drinking, Biomarkers, Case-Control Studies, Female, Humans, Liver Diseases, Alcoholic, Male, Mast Cells, Middle Aged, Substance Withdrawal Syndrome, Tryptases",

author = "Carmen Beceiro and Joaqu{\'i}n Campos and Maria-Angeles Valcarcel and Fenger, {Runa V} and Santiago Lojo and Allan Linneberg and Carmen Vidal and Arturo Gonzalez-Quintela",

note = "Copyright {\textcopyright} 2015 by the Research Society on Alcoholism.",

year = "2015",

month = apr,

day = "1",

doi = "10.1111/acer.12682",

language = "English",

volume = "39",

pages = "672--8",

journal = "Alcoholism: Clinical and Experimental Research",

issn = "0145-6008",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Serum concentrations of mast cell tryptase are reduced in heavy drinkers

AU - Beceiro, Carmen

AU - Campos, Joaquín

AU - Valcarcel, Maria-Angeles

AU - Fenger, Runa V

AU - Lojo, Santiago

AU - Linneberg, Allan

AU - Vidal, Carmen

AU - Gonzalez-Quintela, Arturo

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: Baseline serum tryptase concentrations are commonly used in clinical practice as a marker of the body's mast cell burden. This study aimed to investigate serum tryptase concentrations in heavy drinkers. Methods: Serum tryptase concentrations were determined in 126 heavy drinkers (75% males, median age 47 years) who were admitted to the hospital because of alcohol withdrawal syndrome (n = 60), general symptoms with abnormalities on biochemical tests that indicated acute liver disease (n = 19), complications of advanced liver disease (n = 33), and miscellaneous reasons (n = 14). Results were compared with those of 70 healthy controls (66% males, median age 40 years). Results: Serum tryptase concentrations were lower in heavy drinkers than in healthy controls (median 2.23 μg/l vs. median 3.25 μg/l, p < 0.001). Ten heavy drinkers (7.9%) had undetectable (<1 μg/l) serum tryptase levels versus none of the healthy controls (p = 0.01). The association of low tryptase levels with heavy drinking was independent of age, gender, and smoking status. Among heavy drinkers, the lowest tryptase concentrations were observed in patients with alcohol withdrawal syndrome and patients with general symptoms with abnormalities on biochemical tests that indicated acute liver disease. Furthermore, serum tryptase concentrations were negatively correlated with markers of acute liver damage or alcohol consumption (serum aspartate aminotransferase and gamma-glutamyl transferase). Atopy (skin prick test positivity) was not associated with serum tryptase concentrations in heavy drinkers. Conclusions: Serum concentrations of mast cell tryptase are lower in heavy drinkers than in healthy controls.

AB - Background: Baseline serum tryptase concentrations are commonly used in clinical practice as a marker of the body's mast cell burden. This study aimed to investigate serum tryptase concentrations in heavy drinkers. Methods: Serum tryptase concentrations were determined in 126 heavy drinkers (75% males, median age 47 years) who were admitted to the hospital because of alcohol withdrawal syndrome (n = 60), general symptoms with abnormalities on biochemical tests that indicated acute liver disease (n = 19), complications of advanced liver disease (n = 33), and miscellaneous reasons (n = 14). Results were compared with those of 70 healthy controls (66% males, median age 40 years). Results: Serum tryptase concentrations were lower in heavy drinkers than in healthy controls (median 2.23 μg/l vs. median 3.25 μg/l, p < 0.001). Ten heavy drinkers (7.9%) had undetectable (<1 μg/l) serum tryptase levels versus none of the healthy controls (p = 0.01). The association of low tryptase levels with heavy drinking was independent of age, gender, and smoking status. Among heavy drinkers, the lowest tryptase concentrations were observed in patients with alcohol withdrawal syndrome and patients with general symptoms with abnormalities on biochemical tests that indicated acute liver disease. Furthermore, serum tryptase concentrations were negatively correlated with markers of acute liver damage or alcohol consumption (serum aspartate aminotransferase and gamma-glutamyl transferase). Atopy (skin prick test positivity) was not associated with serum tryptase concentrations in heavy drinkers. Conclusions: Serum concentrations of mast cell tryptase are lower in heavy drinkers than in healthy controls.

KW - Adult

KW - Alcohol Drinking

KW - Biomarkers

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Liver Diseases, Alcoholic

KW - Male

KW - Mast Cells

KW - Middle Aged

KW - Substance Withdrawal Syndrome

KW - Tryptases

U2 - 10.1111/acer.12682

DO - 10.1111/acer.12682

M3 - Journal article

C2 - 25833028

SN - 0145-6008

VL - 39

SP - 672

EP - 678

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

IS - 4

ER -

Serum concentrations of mast cell tryptase are reduced in heavy drinkers

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