Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty

A Juul; Allan Flyvbjerg; Jan Frystyk; J Müller; N E Skakkebaek

Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty

A Juul, Allan Flyvbjerg, Jan Frystyk, J Müller, N E Skakkebaek

84 Citations (Scopus)

Abstract

Circulating IGF-I and IGF binding protein-3 (IGFBP-3) levels both increase in puberty where growth velocity is high. The amount of free IGF-I is dependent on the IGF-I level and on the concentrations of the specific IGFBPs. Furthermore, IGFBP-3 proteolysis regulates the bioavailability of IGF-I. However, the concentration of free IGF-I and possible IGFBP-3 proteolytic activity in puberty has not previously been studied.

Original language	English
Journal	Clinical Endocrinology
Volume	44
Issue number	5
Pages (from-to)	515-23
Number of pages	9
ISSN	0300-0664
Publication status	Published - 1996

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Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty. / Juul, A; Flyvbjerg, Allan; Frystyk, Jan et al.

In: Clinical Endocrinology, Vol. 44, No. 5, 1996, p. 515-23.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty",

abstract = "Circulating IGF-I and IGF binding protein-3 (IGFBP-3) levels both increase in puberty where growth velocity is high. The amount of free IGF-I is dependent on the IGF-I level and on the concentrations of the specific IGFBPs. Furthermore, IGFBP-3 proteolysis regulates the bioavailability of IGF-I. However, the concentration of free IGF-I and possible IGFBP-3 proteolytic activity in puberty has not previously been studied.",

author = "A Juul and Allan Flyvbjerg and Jan Frystyk and J M{\"u}ller and Skakkebaek, {N E}",

year = "1996",

language = "English",

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T1 - Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty

AU - Juul, A

AU - Flyvbjerg, Allan

AU - Frystyk, Jan

AU - Müller, J

AU - Skakkebaek, N E

PY - 1996

Y1 - 1996

N2 - Circulating IGF-I and IGF binding protein-3 (IGFBP-3) levels both increase in puberty where growth velocity is high. The amount of free IGF-I is dependent on the IGF-I level and on the concentrations of the specific IGFBPs. Furthermore, IGFBP-3 proteolysis regulates the bioavailability of IGF-I. However, the concentration of free IGF-I and possible IGFBP-3 proteolytic activity in puberty has not previously been studied.

AB - Circulating IGF-I and IGF binding protein-3 (IGFBP-3) levels both increase in puberty where growth velocity is high. The amount of free IGF-I is dependent on the IGF-I level and on the concentrations of the specific IGFBPs. Furthermore, IGFBP-3 proteolysis regulates the bioavailability of IGF-I. However, the concentration of free IGF-I and possible IGFBP-3 proteolytic activity in puberty has not previously been studied.

M3 - Journal article

SN - 0300-0664

VL - 44

SP - 515

EP - 523

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 5

ER -

Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty

Abstract

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