Serum 25(OH)D and incident type 2 diabetes: a cohort study

L L N Husemoen; T Skaaby; B H Thuesen; Torben Jørgensen; R V Fenger; A Linneberg

doi:10.1038/ejcn.2012.134

Serum 25(OH)D and incident type 2 diabetes: a cohort study

L L N Husemoen, T Skaaby, B H Thuesen, Torben Jørgensen, R V Fenger, A Linneberg

Department of Public Health

42 Citations (Scopus)

Abstract

Background/Objectives: Mild to moderate vitamin D insufficiency has been proposed as a risk factor for several common chronic diseases including type 2 diabetes. This study aimed to examine the association between serum ₂5-hydroxy vitamin D (25(OH)D) and incident diabetes.SUBJECTS/ METHODS:The MONICA10 cohort consists of 2656 participants (men and women aged 41-71 years) who participated in a 10-year follow-up examination during 1993-1994 as part of the MONICA 1 population survey. A total of 2571 participants free of diabetes at baseline and with successful measurement of serum₂5(OH)D were included in the current study. The Danish National Diabetes register enabled identification of 288 cases of incident diabetes during follow-up (median: 16.4 years). Data were analysed by Cox proportional hazard models and associations were expressed as hazard ratios (HRs) with 95% confidence intervals (CIs).Results: Serum₂5(OH)D was inversely associated with incident diabetes adjusted for potential confounders (HR per 25 nmol/l=0.83; 95% CI: 0.72-0.95; P=0.009). A statistically significant interaction was observed between 25(OH)D and waist circumference (WC) (P _interaction=0.042) suggesting an association in persons with a high WC (HR (95%CI) per 25 nmol/l0.74 (0.63-0.88), 218 incident cases) and not in persons with a normal WC (HR (95%CI) per 25 nmol/l=0.98 (0.78-1.24), 70 incident cases).CONCLUSIONS:Low serum₂5(OH)D was associated independently with incident diabetes. The inverse association was only found in overweight-obese and not in normal weight individuals, suggesting that obesity may modify the effect of vitamin D status on the risk of diabetes.

Original language	English
Journal	European Journal of Clinical Nutrition
Volume	66
Issue number	12
Pages (from-to)	1309-14
Number of pages	6
ISSN	0954-3007
DOIs	https://doi.org/10.1038/ejcn.2012.134
Publication status	Published - Dec 2012

Keywords

Adult
Aged
Cohort Studies
Denmark
Diabetes Mellitus, Type 2
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Obesity
Proportional Hazards Models
Risk Factors
Vitamin D
Vitamin D Deficiency
Waist Circumference

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ejcn.2012.134

https://www.nature.com/articles/ejcn2012134.pdf

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@article{048584fc84e542a3b1e1b4cbdde867a7,

title = "Serum 25(OH)D and incident type 2 diabetes: a cohort study",

abstract = "Background/Objectives: Mild to moderate vitamin D insufficiency has been proposed as a risk factor for several common chronic diseases including type 2 diabetes. This study aimed to examine the association between serum 25-hydroxy vitamin D (25(OH)D) and incident diabetes.SUBJECTS/ METHODS:The MONICA10 cohort consists of 2656 participants (men and women aged 41-71 years) who participated in a 10-year follow-up examination during 1993-1994 as part of the MONICA 1 population survey. A total of 2571 participants free of diabetes at baseline and with successful measurement of serum25(OH)D were included in the current study. The Danish National Diabetes register enabled identification of 288 cases of incident diabetes during follow-up (median: 16.4 years). Data were analysed by Cox proportional hazard models and associations were expressed as hazard ratios (HRs) with 95% confidence intervals (CIs).Results: Serum25(OH)D was inversely associated with incident diabetes adjusted for potential confounders (HR per 25 nmol/l=0.83; 95% CI: 0.72-0.95; P=0.009). A statistically significant interaction was observed between 25(OH)D and waist circumference (WC) (P interaction=0.042) suggesting an association in persons with a high WC (HR (95%CI) per 25 nmol/l0.74 (0.63-0.88), 218 incident cases) and not in persons with a normal WC (HR (95%CI) per 25 nmol/l=0.98 (0.78-1.24), 70 incident cases).CONCLUSIONS:Low serum25(OH)D was associated independently with incident diabetes. The inverse association was only found in overweight-obese and not in normal weight individuals, suggesting that obesity may modify the effect of vitamin D status on the risk of diabetes.",

keywords = "Adult, Aged, Cohort Studies, Denmark, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Obesity, Proportional Hazards Models, Risk Factors, Vitamin D, Vitamin D Deficiency, Waist Circumference",

author = "Husemoen, {L L N} and T Skaaby and Thuesen, {B H} and Torben J{\o}rgensen and Fenger, {R V} and A Linneberg",

year = "2012",

month = dec,

doi = "10.1038/ejcn.2012.134",

language = "English",

volume = "66",

pages = "1309--14",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "nature publishing group",

number = "12",

}

TY - JOUR

T1 - Serum 25(OH)D and incident type 2 diabetes

T2 - a cohort study

AU - Husemoen, L L N

AU - Skaaby, T

AU - Thuesen, B H

AU - Jørgensen, Torben

AU - Fenger, R V

AU - Linneberg, A

PY - 2012/12

Y1 - 2012/12

N2 - Background/Objectives: Mild to moderate vitamin D insufficiency has been proposed as a risk factor for several common chronic diseases including type 2 diabetes. This study aimed to examine the association between serum 25-hydroxy vitamin D (25(OH)D) and incident diabetes.SUBJECTS/ METHODS:The MONICA10 cohort consists of 2656 participants (men and women aged 41-71 years) who participated in a 10-year follow-up examination during 1993-1994 as part of the MONICA 1 population survey. A total of 2571 participants free of diabetes at baseline and with successful measurement of serum25(OH)D were included in the current study. The Danish National Diabetes register enabled identification of 288 cases of incident diabetes during follow-up (median: 16.4 years). Data were analysed by Cox proportional hazard models and associations were expressed as hazard ratios (HRs) with 95% confidence intervals (CIs).Results: Serum25(OH)D was inversely associated with incident diabetes adjusted for potential confounders (HR per 25 nmol/l=0.83; 95% CI: 0.72-0.95; P=0.009). A statistically significant interaction was observed between 25(OH)D and waist circumference (WC) (P interaction=0.042) suggesting an association in persons with a high WC (HR (95%CI) per 25 nmol/l0.74 (0.63-0.88), 218 incident cases) and not in persons with a normal WC (HR (95%CI) per 25 nmol/l=0.98 (0.78-1.24), 70 incident cases).CONCLUSIONS:Low serum25(OH)D was associated independently with incident diabetes. The inverse association was only found in overweight-obese and not in normal weight individuals, suggesting that obesity may modify the effect of vitamin D status on the risk of diabetes.

AB - Background/Objectives: Mild to moderate vitamin D insufficiency has been proposed as a risk factor for several common chronic diseases including type 2 diabetes. This study aimed to examine the association between serum 25-hydroxy vitamin D (25(OH)D) and incident diabetes.SUBJECTS/ METHODS:The MONICA10 cohort consists of 2656 participants (men and women aged 41-71 years) who participated in a 10-year follow-up examination during 1993-1994 as part of the MONICA 1 population survey. A total of 2571 participants free of diabetes at baseline and with successful measurement of serum25(OH)D were included in the current study. The Danish National Diabetes register enabled identification of 288 cases of incident diabetes during follow-up (median: 16.4 years). Data were analysed by Cox proportional hazard models and associations were expressed as hazard ratios (HRs) with 95% confidence intervals (CIs).Results: Serum25(OH)D was inversely associated with incident diabetes adjusted for potential confounders (HR per 25 nmol/l=0.83; 95% CI: 0.72-0.95; P=0.009). A statistically significant interaction was observed between 25(OH)D and waist circumference (WC) (P interaction=0.042) suggesting an association in persons with a high WC (HR (95%CI) per 25 nmol/l0.74 (0.63-0.88), 218 incident cases) and not in persons with a normal WC (HR (95%CI) per 25 nmol/l=0.98 (0.78-1.24), 70 incident cases).CONCLUSIONS:Low serum25(OH)D was associated independently with incident diabetes. The inverse association was only found in overweight-obese and not in normal weight individuals, suggesting that obesity may modify the effect of vitamin D status on the risk of diabetes.

KW - Adult

KW - Aged

KW - Cohort Studies

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Obesity

KW - Proportional Hazards Models

KW - Risk Factors

KW - Vitamin D

KW - Vitamin D Deficiency

KW - Waist Circumference

U2 - 10.1038/ejcn.2012.134

DO - 10.1038/ejcn.2012.134

M3 - Journal article

C2 - 23031851

SN - 0954-3007

VL - 66

SP - 1309

EP - 1314

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 12

ER -

Serum 25(OH)D and incident type 2 diabetes: a cohort study

Abstract

Keywords

UN SDGs

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