Abstract
Serological response to treatment of syphilis with orally administered doxycycline or intramuscularly administered penicillin was assessed in patients with concurrent HIV. All HIV-infected individuals diagnosed with syphilis attending 3 hospitals in Copenhagen, Denmark were included. Odds ratios (ORs) with 95% confidence intervals (CI) associated with serological outcome were modelled using propensity-score-adjusted logistic regression analysis. In total, 202 cases were treated with doxycycline or intramuscular penicillin. At 12 months, serological failure was observed in 12 cases (15%) treated with doxycycline and in 8 cases (17%) treated with penicillin (OR 0.78 (95% CI 0.16-3.88), p = 0.76). The serological cure rate at 12 months was highest in patients with primary syphilis (100%), followed by patients with secondary (89%), early latent (71%) and late latent (67%) syphilis (p = 0.006). In conclusion, this study provides evidence for the use of doxycycline as a treatment option when treating a HIV-infected population for syphilis.
| Original language | English |
|---|---|
| Journal | Acta Dermatovenereologica |
| Volume | 96 |
| Issue number | 6 |
| Pages (from-to) | 807-811 |
| Number of pages | 5 |
| ISSN | 0001-5555 |
| DOIs | |
| Publication status | Published - Sept 2016 |
Keywords
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
- Denmark
- Doxycycline
- Female
- HIV Seropositivity
- Humans
- Injections
- Male
- Middle Aged
- Penicillins
- Retrospective Studies
- Syphilis
- Treatment Outcome
- Comparative Study
